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| Number | Title | Issue Date |
| 8178579 | Dioxanes and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable derivati... | 05/15/2012 |
| 8124651 | Palmarumycin based inhibitors of thioredoxin and methods of using same Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth ... | 02/28/2012 |
| 8119687 | Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1-C3... | 02/21/2012 |
| 8114902 | 2-aminobutanol compound and use thereof for medical purposes Disclosed is a 2-aminobutanol compound represented by the following formula (I) or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof, as well as a production method of the ... | 02/14/2012 |
| 8114903 | Cytokine modulators using cyclic glycerides of essential polyunsaturated fatty acids A method of treating a patient in need of therapy for a cytokine dysregulation comprising administering to that patient a therapeutically effective dose of a compound of general formula: (I) wherein R1 and R2 together form a group —(CH2 | 02/14/2012 |
| 8084490 | Sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders. ... | 12/27/2011 |
| 8044094 | Agents for preventing and treating disorders connected to impaired neurotransmission The present invention refers to coumarin ethers of the formula (I), wherein R1 is H, OH or (E)-3-methyl-but-2-enyl, R2 is selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimet... | 10/25/2011 |
| 7919523 | Inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T... | 04/05/2011 |
| 7875649 | 7, 8 and 9-substituted tetracycline compounds 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described. ... | 01/25/2011 |
| 7495025 | Spiro-1,2,4-trioxanes The present invention relates to spiro 1,2,4-trioxanes of general formula 4. This invention more particularly relates to a process for the preparation of a series of spiro 1,2,4-trioxanes. Wherein, Ar represents aryl groups... | 02/24/2009 |
| 7456213 | PEG-poly(ortho ester) graft copolymers and pharmaceutical compositions This invention relates to graft copolymer delivery vehicles comprising a polyethyleneglycol-poly(ortho ester), and to controlled release pharmaceutical compositions comprising the delivery vehicle and an active agent. The graft copolymer delivery vehicles may be the... | 11/25/2008 |
| 7423062 | Insecticidal composition An insecticidal composition which comprises an ester compound given by formula (1): [wherein R represents a methyl or methoxymethyl group] and 2,4,6-triisopropyl-1,3,5-trioxane as active ingredients, wherein the w... | 09/09/2008 |
| 7419986 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, pre... | 09/02/2008 |
| 7384919 | Increased solubility flavanolignan preparations The inventors have devised novel approaches for the preparation of flavanolignan compositions of enhanced solubility and substantially free of toxic contaminants. Such novel approaches are based on spray drying or lyophilizing to dry a diluted preparation of flavano... | 06/10/2008 |
| 7361787 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases ... | 04/22/2008 |
| 7354950 | 1,3-Dioxane derivatives, composition, optical element and display device containing the same A composition includes at least one compound represented by the following Formula (1). In the Formula (1), R1 represents an alkyl group having 1 to 18 carbon atoms, R2 represents a hydrogen atom or a substituent, and R3 represents a ... | 04/08/2008 |
| 7338971 | Treatment of inflammatory, cancer, and thrombosis disorders This invention provides for the treatment of inflammatory, cancer and thrombotic disorders through the administration, in combination, of a COX2 inhibitor, low dose aspirin, and antioxidant flavanoids, flavonoids or isoflavones and at least one of these combinations... | 03/04/2008 |
| 7337839 | Fluid loss additive for enhanced fracture clean-up A hydraulic fracturing method is disclosed that includes designing a fracture treatment including a fluid pumping schedule to fracture a subterranean formation according to a design model that accounts for cumulative filter cake thickness, including polymer concentr... | 03/04/2008 |
| 7335666 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, pre... | 02/26/2008 |
| 7312241 | Diphenylethylene compounds and uses thereof The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof... | 12/25/2007 |
| 7307043 | Aqueous neonicotinoid compositions for seed treatment An aqueous composition suitable for applying insecticides or acaricides to plant propagation materials comprising water, an insecticidally or acaricidally effective amount of at least one nitroimino- or nitroguanidino-compound in free form or in agrochemically usefu... | 12/11/2007 |
| 7294646 | Maxi-k channel blockers, methods of use and process for making the same This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compoun... | 11/13/2007 |
| 7291644 | Indole derivatives Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification and salts thereof. Since the compound represented by the formula (I) binds and antagonize... | 11/06/2007 |
| 7282215 | Supports for photosensitizer formulations The invention is generally related to the field of formulating medicaments in association with a solid support. Such formulations comprising photosensitizers, and their use in photodynamic therapy, are also provided. Methods for the production of the medicament form... | 10/16/2007 |
| 7265130 | NPY Y5 antagonist The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, ... | 09/04/2007 |
| 7259170 | Macrolides containing pharmaceutical compositions A pharmaceutical compound comprising a compound of formula I and a pharmaceutically acceptable 2-amino-1,3-propanediol beside one or more pharmaceutically acceptable excipient(s). ... | 08/21/2007 |
| 7256218 | Biguanide and dihydrotriazine derivatives Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, methods of using the biguanide ... | 08/14/2007 |
| 7244853 | Dioxanes and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and pharmaceutically acceptable... | 07/17/2007 |
| 7220414 | Degradable polyacetal polymers Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribut... | 05/22/2007 |
| 7219731 | Degradable additive for viscoelastic surfactant based fluid systems A method is given for treating a subterranean formation penetrated by a wellbore with a viscosified fluid. The fluid contains a solid hydrolysable polyacid that upon dissolution and hydrolysis releases an acid that is a breaker for the viscosifying system. Suitable ... | 05/22/2007 |
| RE39593 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions. ... | 04/24/2007 |
| 7208526 | Styrylsulfonamides The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmace... | 04/24/2007 |
| 7192965 | 4-(3,3-dihalo-allyloxy)phenoxy alkyl derivatives Compounds of formula wherein A1, A2 and A3 are each independently of the others a bond or a C1–C6alkylene bridge; A4 i... | 03/20/2007 |
| 7183314 | Compound for treatment of anxiety and methods of preparation and use thereof A method for preventing or for treating anxiety in a patient in need thereof comprising administering wogonin to the patient in an effective dose that does not cause sedative or myorelaxant side effects. Methods for extracting wogonin from the roots of Scutelleri... | 02/27/2007 |
| 7176221 | Low dose pharmaceutical composition having uniform drug distribution and potency A method for manufacturing a pharmaceutical composition having uniform drug distribution and potency is described which utilizes silicon dioxide to reduce the loss of active ingredient during the manufacturing process. The method is particularly useful for the manuf... | 02/13/2007 |
| 7169940 | Compounds and pharmaceutical compositions comprising same NST 400 compounds consisting of a unit for partial coordination of Ca2+ ions (CPCU). The NST 400 compounds are optionally conjugated to another pharmaceutically active compound. The compounds and conjugates can be used for affinity filters and for binding negative c... | 01/30/2007 |
| 7166622 | Substituted phenylsulfonamide inhibitors of beta amyloid production Compounds of Formula I, wherein R1–R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs ther... | 01/23/2007 |
| 7166719 | Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferativ... | 01/23/2007 |
| 7163694 | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents from dioxane-based di(ketene acetals). Block copolymers contain these bioerodible poly(ortho esters). These block ... | 01/16/2007 |
| 7157454 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the B1 receptors; they may be used for the preparation of medicinal pr... | 01/02/2007 |
