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| Number | Title | Issue Date |
| 8173697 | Alkoxyalkyl-substituted cyclic keto-enols The invention relates to new alkoxyalkyl-substituted cyclic ketoenols of the formula (I) in which A, B, D, G, W, X, Y and Z have the definitions indicated above, to a number of processes and intermediates for thei... | 05/08/2012 |
| 8124650 | Antitumor combinations containing taxane derivatives and epidophyllotoxins Antitumor combinations comprising a taxane and at least one epidophllotoxin for treating neoplastic diseases are described. ... | 02/28/2012 |
| 8101652 | Antitumour combinations containing taxotere and 5-fluorouracil Antitumor combinations comprising a taxane and at least one antimetabolite for treating neoplastic diseases are described. ... | 01/24/2012 |
| 8053413 | Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists The present invention relates to a method for preventing or ameliorating a sleep-related breathing disorder. The method involves the use of one or a combination of cholecystokinin (CCK) receptor antagonists. ... | 11/08/2011 |
| 8044093 | Pharmaceutical compositions comprising docetaxel and methods for preparation thereof A pharmaceutical composition of docetaxel comprising an effective amount of docetaxel, a polysorbate (TWEEN® compound) and a co-solvent, wherein the co-solvent is at least one member selected from the group consisting of glycerol and polyethylene glycol. The compos... | 10/25/2011 |
| 8039508 | Lipase inhibiting composition Pharmaceutical compositions that contain a lipase inhibitor having a melting point ≧37° C., a sucrose fatty acid ester wherein the sucrose fatty acid ester is a mono-, di-, tri- or tetra-ester, and optionally one or more pharmaceutically acceptable excipients, ar... | 10/18/2011 |
| 8003686 | Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives The present invention relates to the use of acyl derivatives of curcumin, desmethoxy curcumin and bisdesmethoxy curcumin and of curcuminisoxazolide as components of animal feed or feed additives for the improvement of animal performance and the new acyl derivatives ... | 08/23/2011 |
| 7994213 | Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith Disclosed are a coating agent for drug releasing stents, a method for preparing the same and a drug releasing stent coated therewith. The coating agent for drug releasing stents comprises nanoparticles with a biologically active material entrapped therein, wherein t... | 08/09/2011 |
| 7994212 | Method of treating cancer with docetaxel and doxorubicin Antitumor combinations comprising a taxane and at least one antibiotic for treating neoplastic diseases are described. ... | 08/09/2011 |
| 7989490 | Injectable formulations of taxanes for cad treatment Liquid formulations, including solutions and suspensions of the various drugs, agents and/or compounds, may be locally or regionally delivered for the treatment of vascular disease. In each of these instances, antioxidants are utilized to prolong product integrity. | 08/02/2011 |
| 7989489 | Method of treating leukemia with docetaxel and vinca alkaloids Antitumor combinations comprising a taxane and at least one therapeutically useful substance for treating neoplastic diseases are described. ... | 08/02/2011 |
| 7981926 | Fluorotaxoids The invention relates to fluorinated second generation taxoid compounds, pharmaceutical formulations thereof, and their use for inhibiting the growth of cancer cells in a mammal. ... | 07/19/2011 |
| 7915306 | Macrocyclic compounds useful as pharmaceuticals The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammator... | 03/29/2011 |
| 7879904 | 9, 10-α,α-OH-taxane analogs and methods for production thereof The present invention relates to a method for the treatment of cancer in a cancer patient. In particular, the invention provides a method for the treatment comprising administering a taxane compound to a cancer patient, wherein the taxane compound is made by a proce... | 02/01/2011 |
| 7868040 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and an alkylating agent, which has anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-... | 01/11/2011 |
| 7868039 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and vinca alkaloids, which have anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dim... | 01/11/2011 |
| 7863320 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a platinum compound which has anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-d... | 01/04/2011 |
| 7863321 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from anthracyclines and topisomerase II inhibitors, which have anti-tumor activity. Preferably, the present invention rela... | 01/04/2011 |
| 7838551 | Process for the preparation of concentrated, sterile injectable solutions containing docetaxel This invention describes a process for the production of ANHYDROUS active pharmaceutical ingredients (APIs); a process for the preparation of HYDRATED active pharmaceutical ingredients, a process for the preparation of sterile and stable injectable solutions, and th... | 11/23/2010 |
| 7816398 | Fatty alcohol drug conjugates The invention provides conjugates of fatty alcohols and pharmaceutical agents useful in treating cancer, viruses, psychiatric disorders. Compositions, pharmaceutical preparations, and methods of preparation of the fatty alcohols-pharmaceutical agent conjugates are p... | 10/19/2010 |
| 7799826 | Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inh... | 09/21/2010 |
| 7790764 | Biologically active macrolides, compositions, and uses thereof The present invention provides a compound of formula (II). The present invention further provides a composition comprising at least one compound of the present invention and a pharmaceutically acceptable carrier, alone or in combination with at least one addi... | 09/07/2010 |
| 7786164 | Lipophilic di(anticancer drug) compounds, compositions, and related methods Lipophilic di(anticancer drug) compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds. ... | 08/31/2010 |
| 7772274 | Docetaxel formulations with lipoic acid Pharmaceutical formulations comprising docetaxel, solubilizer, and α-lipoic acid, wherein the formulation is substantially free of polysorbates and polyethoxylated castor oil. The solubilizer may comprise glycofurol, acetic acid, benzyl alcohol, or ethanol. The α-... | 08/10/2010 |
| 7750042 | Paclitaxel enhancer compound One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In additio... | 07/06/2010 |
| 7750041 | Preparation for the prophylaxis of restenosis The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effect... | 07/06/2010 |
| 7737177 | Processes for preparing crystalline and amorphous mupirocin calcium Processes are provided for preparing mupirocin calcium dihydrate from pseudomonic acid in a two phase system by using an organic carboxylate. A highly pure composition of amorphous mupirocin calcium is provided, and processes for its preparation by solvent removal, ... | 06/15/2010 |
| 7598290 | Cytotoxic agents comprising new C-2 modified taxanes The invention relates to taxanes and to novel cytotoxic agents comprising taxanes and their therapeutic use as a result of delivering the taxanes to a specific cell population in a targeted fashion by chemically linking the taxane to a cell binding agent. ... | 10/06/2009 |
| 7585889 | Internal 1,15-lactones of fluprostenol and related prostaglandin F analogs and their use in the treatment of glaucoma and intraocular hypertension Novel derivatives of prostaglandin compounds of the F-series (PGF), specifically macrocyclic internal 1,15-lactones of fluprostenol and related PGF analogs, such as cloprostenol or latanoprost. The novel analogs can be formulated into ophthalmic solutions and topica... | 09/08/2009 |
| RE40839 | Taxol treatment of cancer The present invention is a method of treatment for a patient with cancer. In particular, it is a method of treating patients having lymphomas and breast cancer using the microtubule agent, Taxol. The present method of administration, serves to prevent or retard th... | 07/07/2009 |
| 7446126 | Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel A process is provided for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel (I) a synthon useful for the preparation of taxanes with antitumour activity, and intermediates for the preparation thereof. Also described is ... | 11/04/2008 |
| 7438900 | Dendritic encapsulation of active agents A pharmaceutical composition comprising an active agent bound to a scaffold for dendritic encapsulation wherein said scaffold is covalently or non-covalently attached to a polysaccharide. More specifically, the invention is directed to active agent complexes or conj... | 10/21/2008 |
| RE40493 | Porous paclitaxel matrices and methods of manufacture thereof Paclitaxel is provided in a porous matrix form, which allows the drug to be formulated without Cremophor and administered as a bolus. The paclitaxel matrices preferably are made using a process that includes (i) dissolving paclitaxel in a volatile solvent to form a ... | 09/09/2008 |
| 7419998 | Therapeutic methods and compositions involving isoflavones Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R | 09/02/2008 |
| 7414073 | Cytotoxic agents containing novel potent taxanes and their therapeutic use Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selec... | 08/19/2008 |
| 7399783 | Methods for the treatment of scar tissue A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids formulated in a pharmaceutically acceptable topical carrier. The method incl... | 07/15/2008 |
| 7390505 | Nanoparticulate topiramate formulations The present invention is directed to nanoparticulate compositions comprising topiramate. The topiramate particles of the composition have an effective average particle size of less than about 2 microns. ... | 06/24/2008 |
| 7384977 | Water soluble paclitaxel prodrugs Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for ... | 06/10/2008 |
| 7378399 | Avermectins substituted in the 4″ and 4′-positions having pesticidal properties What is described are a compound of the formula (I) Wherein A-B is —CH═CH— or —CH2—CH2—; n is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl;... | 05/27/2008 |
| 7371747 | Cyanoalkylamino derivatives as protease inhibitors The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by... | 05/13/2008 |
