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| Number | Title | Issue Date |
| 8188142 | Polymers from propenyl ether monomers The compounds shown below. R is —O—, —O—(CH2)n—O—, or —(O—CH2—CH2)n—O—; and n is a positive integer. Heating an allyl ether compound in the presence of Fe(CO)5 and a base to form... | 05/29/2012 |
| 7985769 | Compounds and methods for the treatment or prevention of infections The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection. ... | 07/26/2011 |
| 7858658 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substi... | 12/28/2010 |
| 7842718 | Heterocyclic sulfonamide inhibitors of beta amyloid production Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt... | 11/30/2010 |
| 7838550 | Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols Processes for preparing sulfonamide trifluoroalkyl substituted alcohol compounds are provided. Desirably, the compounds are heterocyclic sulfonamide trifluoroalkyl substituted alcohol compounds or phenyl sulfonamide trifluoroalkyl substituted alcohol compounds. ... | 11/23/2010 |
| 7816397 | Phenylcarboxylic acid derivatives and use thereof for the treatment of diabetes The invention relates to compounds of general formula (1): in which R1, R2, R3, R4, R5, A, B, D and E are as defined in Claim 1, and also to the preparation process therefor and the therapeutic use thereof. These compounds can be used in the treatment of path... | 10/19/2010 |
| 7759390 | Inhibitors of CCR9 activity Compounds of formula I, wherein one of R1 and R2 is thienyl which is substituted by halogen and the other of R1 and R2 is substituted phenyl, wherein the substituents are as defined in the claims, with the proviso that the... | 07/20/2010 |
| 7759391 | Pharmaceutical composition comprising thiacremonone for treating colon cancer The present invention relates to an anti-cancer composition, which comprises a sulfur-containing compound thiacremonone as an active ingredient. The active ingredient induces the death of cancer cells by apoptosis through the action of specific inhibition of the act... | 07/20/2010 |
| 7649012 | Compounds, pharmaceutical compositions containing same, and methods of use for same A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IV wherein R21=H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CH2OR25, —C(O)R25, â... | 01/19/2010 |
| 7612108 | 2-phenylthiophene derivative The present invention relates to a 2-phenylthiophene derivative or a salt thereof, wherein the thiophene ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group... | 11/03/2009 |
| 7553868 | Thiophene carboxamides as inhibitors of the enzyme IKK-2 The invention relates to thiophene carboxamides of formula (I) wherein Ar, R1, R2, R3, R4, R5, m and n are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containi... | 06/30/2009 |
| 7547725 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof Compounds of Formula (I), are provided where T is CHO, COR8, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substi... | 06/16/2009 |
| 7521473 | Inhibitors of protein tyrosine phosphatase 1B Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can... | 04/21/2009 |
| 7482376 | Conjugated complement cascade inhibitors The present invention is directed to conjugated complement cascade inhibitors, and a method of treating a patient using a conjugated complement cascade inhibitor. ... | 01/27/2009 |
| 7459479 | Benzylated PDE4 inhibitors The present invention is directed to a method for reducing the emetogenic effects of PDE inhibitors, and more particularly is directed to compounds having PDE4 inhibition activity with little or no emetogenic side-effects, and chemical methods including benzylation ... | 12/02/2008 |
| 7375131 | NF-κB inhibitors The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in ... | 05/20/2008 |
| 7368249 | Methods and compositions for evaluation and modulation of fertility The present invention concerns compositions and methods for regulating or determining fertility in humans and animals. In various embodiments of the invention, LOX and other related enzymes can be used as fertility markers, contraceptive agents, or means of treating... | 05/06/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7358376 | Substituted Thiophene compounds The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R1, R2 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical c... | 04/15/2008 |
| 7351825 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/01/2008 |
| 7351841 | Heterocyclic compounds and thrombopoietin receptor activators A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C | 04/01/2008 |
| 7320983 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 01/22/2008 |
| 7300951 | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof Compounds of Formula (I), are provided where T is CHO, CON, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substit... | 11/27/2007 |
| 7288676 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulph... | 10/30/2007 |
| 7272252 | Automated system for combining bright field and fluorescent microscopy A method and apparatus for automated analysis of transmitted and fluorescently labeled biological samples, wherein the apparatus automatically scans at a low magnification to acquire images which are analyzed to determine candidate cell objects of interest. Once can... | 09/18/2007 |
| 7250430 | Thiophene-and thiazolesulfonamides as antineoplastic agents The present invention provides antineoplastic compounds of the formula: and antineoplastic methods. ... | 07/31/2007 |
| 7235584 | Non-psychotropic cannabinoids Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) ... | 06/26/2007 |
| 7235664 | Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, | 06/26/2007 |
| 7226991 | Phenylalanine derivatives Disclosed herein are phenylalanine derivative compounds of the following formula W—Y—(AA)n—Z wherein Y is a phenylalanyl radical, AA is an amino acid, n is an integer of 1 to 15, and substituent variables W and Z are as described... | 06/05/2007 |
| 7208528 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 04/24/2007 |
| 7202236 | Modified release pharmaceutical formulation A modified release pharmaceutical composition comprising, as active ingredient, a compound of formula (I), wherein R1 represents C?1-2#191 alkyl substituted by one or more fluoro substituents; R2 represents hydrogen, hydroxy, methoxy or ethoxy;... | 04/10/2007 |
| RE39530 | 3-amino-3-arylpropan-1-ol-compounds, their preparation and use 3-amino-3-arylpropan-1-ol compounds corresponding to the formula I in which R1 to R5, A and X have the meanings according to claim 1, and their preparation and use as medicaments. ... | 03/27/2007 |
| 7190818 | Method and apparatus for automated image analysis of biological specimens A method and apparatus for automated cell analysis of biological specimens automatically scans at a low magnification to acquire images (288) which are analyzed to determine candidate cell objects of interest. The low magnification images are converted from a... | 03/13/2007 |
| 7177454 | Automated detection of objects in a biological sample A method, system, and apparatus are provided for automated light microscopic for detection of proteins associated with cell proliferative disorders. ... | 02/13/2007 |
| 7173055 | Pyrazolecarboxamide and pyrazolethioamide as fungicide Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R1 is C1–C3alkyl, C1–C3haloalkyl, C1–C3alkoxy-C1–C3alkyl or C1–C3 | 02/06/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7160923 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 01/09/2007 |
| 7144897 | Hydroxy alkyl amines Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compou... | 12/05/2006 |
| 7138530 | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I... | 11/21/2006 |
| 7129233 | Mandelic acid derivatives and their use as thrombin inhibitors There is provided a compound of formula I wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including pro... | 10/31/2006 |
