Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 8124649 | Oxindole compounds The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions incl... | 02/28/2012 |
| 8084489 | Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have glucagon receptor antagonist or inverse agonist activity, as well as methods of using these compounds and intermediates and methods for preparing s... | 12/27/2011 |
| 7994211 | Bicyclo[2.2.1]hept-7-ylamine derivatives and their uses Compounds of formula (I) have muscarinic M3 receptor modulating activity; Formula (I) wherein A is an oxygen atom or group —N(R12)—; (i) R1 is C1-C6-alkyl or a hydrogen atom; and R2 is a hydrogen atom or a g... | 08/09/2011 |
| 7989488 | Compositions and methods for storing holographic data In one aspect, the present invention provides a novel thiophene-containing polynitrone compound having structure (II) wherein R1 is independently at each occurrence a C1-C20 aliphatic radica... | 08/02/2011 |
| 7964633 | Sulfonamide derivatives Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R1, R2, m and n have the meaning given in claim 1 and which can be used in the form of pharma... | 06/21/2011 |
| 7915305 | Thiophene-carboxamides useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of protein kinase represented by formula (I): or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositio... | 03/29/2011 |
| 7803837 | 4-oxo-4,5-dihydro-furan-2-carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof System for selecting a color shade comprising a very small number of color display cards with mixed shades of two or more colors. The system comprises means for selecting one shade among mixed shades, means for presenting the selected mixed shade as well as means fo... | 09/28/2010 |
| 7700643 | Polymerisable thieno[3,2-b]thiophenes The invention relates to novel polymerisable thieno[3,2-b]thiophenes, to their use as semiconductors or charge transport materials, in optical, electro-optical or electronic devices like for example liquid, crystal displays, optical films, organic field effect trans... | 04/20/2010 |
| 7671083 | P-alkoxyphenylen-thiophene oligomers as organic semiconductors for use in electronic devices This invention provides phenylene-thiophene compounds that exhibit useful electronic properties such as high mobility and high on/off ratio. The invention also provides electronic devices incorporating these compounds. These devices include field effect transistors ... | 03/02/2010 |
| 7435750 | Method of using substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invent... | 10/14/2008 |
| 7423060 | Thiophene hydroxamic acid derivatives and their use as HDAC inhibitors Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as wel... | 09/09/2008 |
| 7414073 | Cytotoxic agents containing novel potent taxanes and their therapeutic use Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selec... | 08/19/2008 |
| 7410999 | Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.... | 08/12/2008 |
| 7402608 | Compounds and methods for the treatment or prevention of infections Compounds represented by formula: wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a Flaviviridae viral infection in ... | 07/22/2008 |
| 7393846 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 07/01/2008 |
| 7388012 | (Hydrazido)(amino)thiophene compounds Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, ... | 06/17/2008 |
| 7371874 | 6-Alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor The present invention relates to a noble 6-alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic t... | 05/13/2008 |
| 7368603 | Method for purifying compounds containing functional groups The present invention relates to a method for producing a saturated organic compound bearing at least one functional group from a mixture which comprises this saturated organic compound containing at least one functional group and also one or more other organic comp... | 05/06/2008 |
| 7368477 | Benzofuranyl alkanamine derivatives and uses thereof Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R1′, R2, R3, R4, n, and Ar are as defined, and described in clas... | 05/06/2008 |
| 7365094 | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents The present invention relates to compounds of the general formula (II) and salts and physiologically functional derivatives thereof, for the use as a medicament. ... | 04/29/2008 |
| 7365089 | Triazolo-quinolin derivatives useful as adenosine receptor ligands The present invention relates to adenosine A3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the gen... | 04/29/2008 |
| 7354940 | 2,5-dioxoimidazolidin-4-yl acetamines and analogues as inhibitors of metalloproteinase mmp12 The invention provides compounds of formula (I) in which L, X, Y, Z1, Z2, R1, R2, R3 and G2 have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions... | 04/08/2008 |
| 7354936 | 2-phenylpyran-4-one derivatives The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula processes for their preparation, pharmaceutical compositions containing them, and their medical uses. ... | 04/08/2008 |
| 7332492 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor Compounds of formula (I): wherein: X is a group of formula (B): and R1, R2 | 02/19/2008 |
| 7332513 | Thiazole-based nitric oxide donors having acyl substituent(s) and uses thereof Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or dec... | 02/19/2008 |
| 7329765 | Benzothiophene compounds having antiinfective activity Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity. ... | 02/12/2008 |
| 7326729 | CXCR1 and CXCR2 chemokine antagonists The present invention is directed to a compound having the general structure of formula (1): useful for the treatment, prevention or amelioration of a CXCR1 or CXCR2 chemokine-mediated disease. ... | 02/05/2008 |
| 7319111 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use. ... | 01/15/2008 |
| 7301037 | Charged compounds comprising a nucleic acid binding moiety and uses therefor Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and m... | 11/27/2007 |
| 7288538 | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use. ... | 10/30/2007 |
| 7288665 | Process for selective derivatization of taxanes Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(... | 10/30/2007 |
| 7282518 | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to benzimidazole molecules that are cellu... | 10/16/2007 |
| 7226944 | Taxanes having a C7 carbonate substituent Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents. ... | 06/05/2007 |
| 7226945 | Estrogen receptor-β ligands A method for treating a disease associated with the estrogen receptor-β, comprising the step of administiering a therapeutically-effective amount of a compound that satifies the equation: KiαA/KiβA>25, optionally having general structure (I)... | 06/05/2007 |
| 7223780 | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their us... | 05/29/2007 |
| 7220734 | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists The present invention encompasses compounds of Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejecti... | 05/22/2007 |
| 7217819 | Cytotoxic agents comprising taxanes and their therapeutic use A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking gro... | 05/15/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7211570 | Treatment of EBV and KHSV infection A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceu... | 05/01/2007 |
| 7208510 | Fungicidal combinations of active substances The present invention relates to fungicidally active compound combinations of a fluorobenzothiazole derivative of the formula (I) and at least one of the compounds listed in the disclosure. ... | 04/24/2007 |
