Class 514/442 - Nitrogen bonded directly to the hetero ring by nonionic bonding

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein nitrogen is bonded directly to the
No. of patents: 35
Last issue date: 09/11/2007

Number	Title	Issue Date
7268139	Methods of promoting osteogenesis The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxill...	09/11/2007
7262204	Modulation of CCR4 function Compounds and compositions are provided that bind to the CCR4 chemokine receptor and which are useful for treating diseases associated with CCR4 activity, such as contact hypersensitivity. ...	08/28/2007
6921773	Use of α-1AR subtype-selective drugs in patients with acute myocardial infarction The present invention relates to the use of α1aAR-selective and/or α1a/α1d-selective antagonists in a method of preventing restenosis after myocardial infarction and re-perfusion. The invention further relates to a method of ident...	07/26/2005
6610707	Heterocyclic compounds as inhibitors of rotomase enzymes Compounds of the formula: ##STR1## wherein R1, Y, W, A and R2 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be ...	08/26/2003
6605637	Lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration of antioxidants or entities trapping reactive oxygen speci...	08/12/2003
6596745	Method for treating fibrotic diseases with azolium chroman compounds Provided is a method of treating or ameliorating hypertension in an animal comprising administering an effective amount of a compound of formula I: ##STR1##...	07/22/2003
6303593	3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity The present invention is directed to pyrrolidine compounds of the formula I: ##STR1## (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine ...	10/16/2001
6046228	Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof The present invention is directed to pharmaceutical compositions including a saturated 1,2-dithiaheterocyclic compound having antiviral activity. The present invention also provides a kit containing the pharmaceutical composition and methods of treating o...	04/04/2000
5985897	Benzothiphene compounds, intermediates, compositions, and methods The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia, and estrogen-dependent cancer....	11/16/1999
5962475	Substituted benzo(B)thiophene compounds having activity as selective estrogen receptor modulators The present invention provides compounds with nitrogen, sulfur or carbon linked basic side chains of formula ##STR1## where R1 and R2 are independently hydrogen, halo, hydroxy, alkoxy, alkylcarbonyloxy, alkoxycarbonyl, alkoxycar...	10/05/1999
5948796	BenzoB!thiophene compounds, intermediates, formulations, and methods This invention relates to the field of pharmaceutical and organic chemistry and provides benzothiophene compounds, intermediates, formulations, and methods....	09/07/1999
5856340	Method of treating estrogen dependent cancers A method for alleviating the symptoms of post-menopausal syndrome comprising administering to a woman in need thereof an effective amount of a compound of formula I ##STR1## wherein R1a is --H or --OR7a in which R7a i...	01/05/1999
5843963	Benzothiophene compounds, intermediates, processes, compositions, and methods The invention provides benzothiophene compounds, of formula I, ##STR1## wherein R1, R2, R3, R4 and n are as defined in the specification, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascu...	12/01/1998
5643896	2-Benzyl-3-arylbenzothiophenes The present invention provides a compound of formula I ##STR1## wherein R1 is hydrogen, a hydroxy protecting group, or methyl; R2 and R3 are independently C1 -C6 alkyl, or R2 and R3	07/01/1997
5356924	Pesticidal benzodioxole Compounds of the general formula: ##STR1## wherein R1 and R2 each independently represents a halogen atom or an alkyl, alkoxy, haloalkyl, haloalkoxy, alkoxycarbonyl, alkenoxy, cyano or nitro group; R3 and R4	10/18/1994
5041440	Dithiolane derivatives Novel dithiolane derivatives of formula: ##STR1## wherein X is, a C2 -C7 alkylcarbonyl group, benzoyl group, benzoyl group substituted with 1-3 groups selected from halogen, C1 -C4 alkyl, and C1 ...	08/20/1991
4725619	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments The present invention is concerned with the therapeutic composition comprising as an active ingredient a compound of the formula: and salts thereof; wherein Ar and Ar1 are independently phenyl, naphthyl or a nitrogen, oxygen, or sulfur heterocyclic ...	02/16/1988
4675340	Insecticidal and miticidal oxime N-alkyl-N-଱-haloacylcarbamate derivatives, compositions, and method of use therefor Pesticidal oxime N-alkyl-N-଱-haloacyl-carbamates represented by the structure: ##STR1## wherein R represents an imino radical, R' and R" represent alkyl radicals and X is chlorine, fluorine or bromine....	06/23/1987
4514406	Oxime ethers and their use A compound of the formula: ##STR1## wherein R1 and R2 are, same or different, each a hydrogen atom, a C1 -C3 alkyl group optionally substituted with halogen, an alkoxyalkyl or alkylthioalkyl group of the fo...	04/30/1985
4435420	Anti-inflammatory agents and antiasthmatic agents N-(1,3-dithiolan-2-ylidene)-4-alkylanilines are useful as anti-inflammatory agents, as analgesic agents and as antiasthmatic agents. The compounds involved can be prepared by the reaction of an appropriate 4-alkylaniline with a methyl(1,3-dithiolan-2-ylid...	03/06/1984
4391818	4-(Substituted alkyl)-N-(1,3-dithiolan-2-ylidene(aniline N-(1,3-dithiolan-2-ylidene)-4-alkylanilines having a hydroxy, alkoxy or alkanoyloxy substituent on the alkyl group are useful as anti-inflammatory agents, as analgesic agents and as antiasthmatic agents. The compounds involved can be prepared by the react...	07/05/1983
4382957	Symmetrical insecticidal bis-carbamate compounds Symmetrical N-substituted bis-carbamoyl sulfide compounds exhibit exceptional broad spectrum pesticidal activity coupled with extremely low mammalian toxicity and phytotoxicity....	05/10/1983
4369189	Novel unsymmetrical formamidine-sulfenylated carbamate compounds Novel unsymmetrical formamidine-sulfenylated carbamate compounds exhibit broad-spectrum insecticidal, miticidal and nematocidal activity....	01/18/1983
4341795	Asymmetrical bis-carbamate compounds Asymmetrical N-substituted bis-carbamoyl sulfide compounds exhibit exceptional broad spectrum pesticidal activity coupled with extremely low mammalian toxicity and phytotoxicity....	07/27/1982
4327110	Pesticidal symmetrical N-substituted bis-carbamoyloximino disulfide compounds Symmetrical N-substituted bis-carbamoyloximino disulfide compounds exhibit outstanding nematocidal, miticidal and insecticidal activity, coupled with substantially reduced mammalian toxicity and phytotoxicity as compared to known pesticidal compounds havi...	04/27/1982
4281011	Insecticidal N-methyl-N-(benzene sulfonic acid methylamide-N'-sulfenyl)-carbamic acid oxime esters N-methyl-N-(benzene sulfonic acid methylamide-N'-sulfenyl)-carbamic acid esters of the formula ##STR1## in which X is halogen, C1 -C6 alkyl or hydrogen, and R is a phenyl, naphthyl, benzodioxolanyl or indanyl radical optionally ...	07/28/1981
4234580	Carbamate thiosulfenylcarbamoyl fluoride compounds Carbamate thiosulfenylcarbamoyl fluoride compounds are insecticidal and miticidal compounds and are also useful intermediates in the preparation of pesticidally active bis-carbamate disulfide compounds....	11/18/1980
4232035	Carbamate pesticidal compounds compositions and methods of use Novel N-dithioalkyl and N-dithioaryl substituted cyclic carbamoyloximes exhibit exceptional pesticidal activity....	11/04/1980
4212883	Sulfonic acid-N'-methylamido-N'-sulfenyl-N-methyl-carbamic acid esters Sulfonic acid-N'-methylamide-N'-sulfenyl-N-methyl-carbamic acid esters of the formula ##STR1## in which R1 is dialkylamino with 1-4 carbon atoms in each alkyl group, phenyl substituted in the o- or m-position by halogen or by alkyl wi...	07/15/1980
4163059	Pesticidally active 4,5-dichloro-3-substituted-phenylimino-1,2-dithiolenes 4,5-Dichloro-3-substituted-phenylimino-1,2-dithiolenes of the formula ##STR1## in which R is optionally chlorine-substituted or methoxy-substituted phenyl which carries at least one substituent selected independently from fluorine, bromine, iodine, c...	07/31/1979
4131683	ω-(1,3-Dithiolan-2-imino) substituted acetic acids ω-(1,3-Dithiolan-2-imino) substituted acetic acids are prepared useful as antibacterial agents, inhibitors of cholesterol and fatty acid synthesis, anti-inflammatory agents and as intermediates for cephalosporin antibiotics....	12/26/1978
4060628	2-(Alkylhalophenylimino)dithiolanes and ectoparasiticidal composition and method 2-(Alkylhalophenylimino)-1,3-dithiolanes are ectoparasiticidal agents. The compounds, of which 2-(2-methyl-4-chlorophenylimino)-1,3-dithiolane is a typical example, are obtained by condensation of a salt of the corresponding N-phenyldithiocarbamic acid an...	11/29/1977
4004019	Insect control compounds The invention is novel hydrocarbon ethers of aminophenol derivatives, and their use in preventing the proliferation of insects by interfering with their normal development and growth pattern....	01/18/1977
3992549	Pesticidal compositions and methods of killing pests using N-polyhalo-alkanesulfenyl carbamoyloximino di-sulfur containing heterocyclic compounds Certain N-polyhaloalkanesulfenyl carbamoyloximino di-sulfur containing heterocyclic compositions have exceptional pesticidal properties and low mammalian toxicity....	11/16/1976
3968232	N-methyl-N-alkoxycarbonylsulphenyl-carbamates N-methyl-N-alkoxycarbonylsulphenyl-carbamates of the formula ##EQU1## in which R1 is C1.sub.-6 alkyl, and R2 is phenyl; naphthyl; indanyl; phenyl, naphthyl or indanyl substituted by trihalomethyl, halogen, nitro, nitrile, ...	07/06/1976

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Class 514/442 - Nitrogen bonded directly to the hetero ring by nonionic bonding