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| Number | Title | Issue Date |
| 7498355 | Derivatives of 4- or 5-aminosalicylic acid The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bo... | 03/03/2009 |
| 7326695 | Anti-bacterial agents based upon oxoanion binding Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independen... | 02/05/2008 |
| 7202366 | Heterocyclic analogs of diphenylethylene compounds Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II di... | 04/10/2007 |
| 7199122 | Methods for inhibiting angiogenesis Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for us... | 04/03/2007 |
| 7105552 | Heterocyclic analogs of diphenylethylene compounds Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II di... | 09/12/2006 |
| 7101676 | Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an oligonucleotide which comprises admixing an NCp7 polypeptide with at one labe... | 09/05/2006 |
| 7084136 | Drug composition antagonistic to both PGD/TXA receptors A compound of the formula (I): wherein A is alkylene optionally having an unsaturated bond; R is —C(═O)—R1; R1 is hydroxy or the like; m is 0 or 1; p is 0 or 1; X1 and X | 08/01/2006 |
| 7074776 | Anti-bacterial agents based upon oxoanion binding Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independen... | 07/11/2006 |
| 7038062 | Synthesis of cyclic trithiocarbonates from epoxides This invention provides a low cost technique for synthesizing cyclic trithiocarbonates by a simple one step process from epoxides that can be conducted under atmospheric pressure. This synthesis can be depicted as follows: | 05/02/2006 |
| 7012148 | Compositions and methods for thionation during chemical synthesis reactions Compositions and methods for using these compositions to produce high yields of thionated compounds are provided. ... | 03/14/2006 |
| 7008545 | Synergistic biocidal mixtures Synergistic mixtures of biocides and their use to control the growth of microorganisms in aqueous systems are disclosed. The method of using the synergistic mixtures entails adding an effective amount of a nitrogenous compound activated by an oxidant and at least on... | 03/07/2006 |
| 6905711 | Antimicrobial agents, products incorporating said agents and methods of making products incorporating antimicrobial agents An antimicrobial agent includes an oligodynamic metal ion in a hydrophilic polymer binder or carrier. According to a presently preferred embodiment, the metal ion is silver and the hydrophilic polymer is polyurethane. According to a method of the invention, the anti... | 06/14/2005 |
| 6844423 | Compositions and methods for regulating bacterial pathogenesis The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimul... | 01/18/2005 |
| 6838477 | Lactacystin analogs Described herein are compounds related to lactacystin and lactacystin β-lactone, pharmaceutical compositions containing the compounds, and methods of use. ... | 01/04/2005 |
| 6821999 | Methods for inhibiting the production of TSST-1 The present invention relates to inhibiting the production of TSST-1 using absorbent products and non-absorbent products comprising an additive, as well as methods for inhibiting such production. The absorbent and non-absorbent products or articles include an effect... | 11/23/2004 |
| 6642270 | 7-substituted fused ring tetracycline compounds 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.... | 11/04/2003 |
| 6599928 | Therapeutic inhibitor of vascular smooth muscle cells Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein t... | 07/29/2003 |
| 6559176 | Compounds and methods for regulating bacterial growth and pathogenesis The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.... | 05/06/2003 |
| 6514990 | Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-... | 02/04/2003 |
| 6369097 | Treatment and prevention of hepatic disorders The present invention provides new methods for the treatment of viral hepatitis C involving the administration of vitamin E and other compounds with antioxidant properties. Treatment with high doses of vitamin E is effective in treating chronic hepatitis ... | 04/09/2002 |
| 6335358 | Lactacystin analogs Compounds related to lactacystin and lactacystin ଲ-lactone, pharmaceutical compositions containing the compounds, and methods of use.... | 01/01/2002 |
| 6326025 | Tissue reactive adhesive compositions The present invention is directed to a biocompatible tissue reactive composition comprising a functionalized polymer having tissue reactive substituents that are capable of forming covalent bonds with tissue associated functional groups.... | 12/04/2001 |
| 6268390 | Therapeutic inhibitor of vascular smooth muscle cells Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein t... | 07/31/2001 |
| 6251874 | Method of inhibiting human immunodeficiency virus using hydroxurea and a reverse transcriptase inhibitor in vivo A method for treating HIV infection in human beings comprising the step of measuring viremia, and if viremia is less than 50,000-100,00 copies per milliliter, administering a combination of compounds selected from the group consisting of hydroxyurea, and ... | 06/26/2001 |
| 6214862 | Lactacystin analogs Compounds related to lactacystin and lactacystin ଲ-lactone, pharmaceutical compositions containing the compounds, and methods of use.... | 04/10/2001 |
| 6046228 | Anti-viral pharmaceutical compositions containing saturated 1,2-dithiaheterocyclic compounds and uses thereof The present invention is directed to pharmaceutical compositions including a saturated 1,2-dithiaheterocyclic compound having antiviral activity. The present invention also provides a kit containing the pharmaceutical composition and methods of treating o... | 04/04/2000 |
| 5977086 | Method of inhibiting human immunodeficiency virus by combined use of hydroxyurea, a nucleoside analog, and a protease inhibitor A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a combination of compounds selected from the group consisting of hydroxyurea, a nucleoside analog, an... | 11/02/1999 |
| 5948813 | Method of preventing allograft rejection A method for suppressing the rejection of allogeneic transplants in a mammal, including a human, comprising administering to said mammal an effective amount of the compound of the formula ##STR1## wherein n, A, B, R1 and R2 are ... | 09/07/1999 |
| 5798379 | UCS1025 compounds UCS1025 compounds represented by the following formula (I): ##STR1## wherein R represents hydrogen or hydroxyl group, or tautomers or pharmacologically acceptable salts thereof.... | 08/25/1998 |
| 5750560 | Therapeutic compositions based on 1,2-dithiole-3-thione derivatives The present invention relates to therapeutic compositions based on compounds chosen from the formulae: ##STR1## in which: X is chosen from .dbd.S, .dbd.O, .dbd.SO, .dbd.N--OH, .dbd.N--R5, .dbd.N--NH--CONH2, .dbd.N--NH--CSNH... | 05/12/1998 |
| 5747505 | Heterocyclic aryl-, alkyl- and cycloalkylacetamides The heterocyclic aryl-, alkyl- and cycloalklacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compoun... | 05/05/1998 |
| 5728710 | Rapamycin derivatives Rapamycin derivatives; pharmaceutical compositions comprising such rapamycin derivatives and pharmaceutically acceptable carriers or diluents; and methods of using such derivatives to inhibit pathogenic fungi growth inhibition, inhibit immunosuppression o... | 03/17/1998 |
| 5703114 | Use of 4,5-dicyano-1-3-dithiole-2-one (or thione) as antimicrobial and marine antifouling agents Disclosed is the use of compositions employing a 4,5-dicyano-1,3-dithiole-2-one (or thione) compound corresponding to the formula: ##STR1## wherein Z is oxygen or sulfur as the active antimicrobial and marine antifouling agent.... | 12/30/1997 |
| 5691338 | 1,2-dithiole-3 thiones for the treatment of reverse transcriptase-dependent viral infections This invention provides a method of inhibiting the replication of a reverse transcriptase-dependent virus in cells which comprises contacting infected cells with an effective amount of a 1,2-dithiole-3-thione. A composition for inhibiting reverse transcri... | 11/25/1997 |
| 5661176 | (2-one (or thione)-1,3-dithiole-4,5-diyl)-bis(thiomethylthiocyanate), compounds for use as antimicrobial and marine antifouling agents Disclosed are (2-one (or thione)-1,3-dithiole-4,5-diyl)bis(thiomethylthiocyanate) compounds corresponding to the formula: ##STR1## wherein Z is oxygen or sulfur, compositions containing said compounds and their use as antimicrobial and marine an... | 08/26/1997 |
| 5631277 | (2-one (or thione)-1,3-dithiole 4,5-diyl) bis(thiocyanate) compounds, compositions containing the compounds and their use as an antimicrobial and marine antifouling agents Disclosed is (2-thione-1,3-dithiole 4,5-diyl) bis(thiocyanate), its preparation and its use as an antimicrobial and marine antifouling agent.... | 05/20/1997 |
| 5618835 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.... | 04/08/1997 |
| 5531989 | Immunoglobulin and fiber-containing composition for human gastrointestinal health A composition for restoring and maintaining gastrointestinal health comprises 40-60% by weight of an immunoglobulin composition comprising concentrated immunologically active immunoglobulins and 40-60% by weight of soluble dietary fiber selected from inul... | 07/02/1996 |
| 5470871 | Therapeutic compositions based on 1,2-dithiole-3-thione derivatives The present invention relates to therapeutic compositions based on compounds chosen from the formulae: ##STR1## in which: X is chosen from .dbd.S, .dbd.O, .dbd.SO, .dbd.N--OH, .dbd.N--R5, .dbd.N--NH--CONH2, .dbd.N--NH--CSNH... | 11/28/1995 |
| 5434151 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira... | 07/18/1995 |
