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A method of swing on a swing is disclosed, in which a user positioned on a standard swing suspended by two chains from a substantially horizontal tree branch induces side to side motion by pulling alternately on one chain and then the other.
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| Number | Title | Issue Date |
| 8178577 | Tricyclic derivatives as potent and selective histone deacetylase inhibitors The present invention relates to certain tricyclic derivatives which are capable of inhibiting histone deacetylases. The compounds of this invention are therefore useful in treating diseases associated with abnormal histone deacetylase activities. Pharmaceutical com... | 05/15/2012 |
| 8158674 | Chalcogenoxanthylium dyes for purging blood pathogens and for photodynamic therapy Provided are chalcogenoxanthylium compounds which can effectively be used as sensitizers in photodynamic therapy, virucides in photodynamic antimicrobial chemotherapy and reversal agents of Pgp function in cancer cells. Further provided is a general method for the p... | 04/17/2012 |
| 7423029 | Compounds to promote regeneration of bone marrow Embodiments of the present invention include the use of heterocyclic trialkyl ammonium-containing compounds to promote regeneration of bone marrow from endogenous or exogenous stem/progenitor cells and to normalize blood cell and platelet counts. ... | 09/09/2008 |
| 7332519 | Spirocyclic cyclohexane compounds Spirocyclic cyclohexane compounds, methods for their production, pharmaceutical compositions containing these compounds, and the use of these spirocyclic cyclohexane compounds for treating conditions associated with the nociceptin/ORL1 receptor system, e.g. pain, dr... | 02/19/2008 |
| 7288560 | Spirocyclic cyclohexane derivatives The present invention relates to spirocyclic cyclohexane compounds, to methods for their production, to pharmaceutical compositions containing these compounds, to methods of treatment using such compounds and to the use of such spirocyclic cyclohexarie compounds for... | 10/30/2007 |
| 7268148 | Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen biosynthesis. This invention treats scarring and inflammation accompanying ... | 09/11/2007 |
| 7268157 | Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity Disclosed is the preparation and pharmaceutical use of substituted arylalcanoic acid derivatives of Formula I, wherein ring A, ring B, R1, R2, R3, R4, R5, X, Alk1, Alk2, Ar1, and... | 09/11/2007 |
| 7238725 | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes. ... | 07/03/2007 |
| 7235583 | Fatty acid-anticancer conjugates and uses thereof The invention provides conjugates of fatty acids and anticancer agents useful in treating cancer, and compositions and formulations thereof. Methods for using the conjugates also are provided. ... | 06/26/2007 |
| 7223789 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 05/29/2007 |
| 7223774 | Benzamide 2-hydroxy-3-diaminoalkanes The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 05/29/2007 |
| 7126011 | Process for the preparation of thioxanthones Processes are described for the preparation of thioxanthones (Formula I). A reactant mixture of a 2-chlorothiobenzoyl chloride (Formula II) and an aromatic compound (Formula III) is added to a slurry of a Friedel-Crafts catalyst in an organic Friedel-Crafts solvent.... | 10/24/2006 |
| 7115605 | Peptide deformylase inhibitors PDF inhibitors and novel methods for their use are provided. ... | 10/03/2006 |
| 7105569 | Fungicidal active compound combinations New active compound combinations of valinamide derivatives of the formula (I) in which R1 and R2 has the meaning given in the description, with k... | 09/12/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 6825226 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present i... | 11/30/2004 |
| 6806283 | Selective serotonin receptor antagonists and therapeutic applications thereof Spiro[9,10-dihydroanthracene]-9,3′-pyrrolidine (SPAN) and derivatives thereof are provided as selective serotonin receptor antagonists. The compounds are selective, high affinity antagonists of 5-HT2 serotonin receptors. The compounds are useful as anti... | 10/19/2004 |
| 6784202 | Cubane derivatives as metabotropic glutamate receptor agonists or antagonists and process for their preparation The present invention relates to therapeutically active cubane compounds, a method of preparing the same, and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases of the central nervous system related to the me... | 08/31/2004 |
| 6767919 | High specificity anticancer agents A process for producing new anticancer drugs such that the drugs can be administered in a nontoxic, proto-drug form and, subsequent to a time delay which allows for differential concentration in the target cancer or invasive tissues or cells, the non-toxic drug is t... | 07/27/2004 |
| 6750244 | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits... | 06/15/2004 |
| 6730697 | Dihydrothiaphenanthrenecarbonylguanidines: composition, process of making, and use as medicament or diagnostic aid Dihydrothiaphenanthrenecarbonylguanidine compound of formula I These compounds are potentially suitable as antiarrythmic medicaments with a cardioprotective component for prophylaxis of an infarction and treatment of inf... | 05/04/2004 |
| 6693136 | Fluorenes and anthracenes that inhibit P2X3 and P2X2/3 containing receptors Compounds of formula (I) ##STR1## are novel P2X3 and P2X2 /P2X3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.... | 02/17/2004 |
| 6620834 | Medicinal compositions for treating colorectal cancer Medicinal compositions for colorectal cancer to be administered to the large intestine by taking advantage of preparations disintegrating in the large intestine, characterized by containing a cyclooxygenase inhibitor and an HMG-CoA reductase inhibitor. Th... | 09/16/2003 |
| 6613797 | Xanthone analogs for treating infectious diseases and complexation of heme and porphyrins Therapeutic compounds and compositions for the treatment of infectious diseases are disclosed. The compounds are xanthones and xanthone derivatives, such as 3,5-bis-&3xb5;-(N,N-diethylamino)amyloxyxanthone. The described compositions include such compound... | 09/02/2003 |
| 6602903 | Substituted heterocyclic compounds The invention relates to compounds of formula (I): ##STR1## and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.... | 08/05/2003 |
| 6566389 | Therapeutic uses of melatonin A method for treating or preventing symptoms of tardive dyskensia comprises administering melatonin to patient exhibiting or liable to develop such symptoms. The melatonin is administered in an amount effective to ameliorate or prevent symptoms of tardive... | 05/20/2003 |
| 6521641 | Male anti-fertility agents Methods and compositions for inhibiting or preventing spermatogenesis in a male mammal. Also disclosed are compounds and formulations for use in such methods.... | 02/18/2003 |
| 6514967 | Compound for preparing medicines for treating pathologies involving extracellular glutamate, and methods for obtaining same The invention relates to compounds of the following general formula (I): ##STR1## in which: R1 and R2 represent a hydrogen atom, or form a ring, especially a benzene ring, R3 represents a hydrogen atom or an alkyl group, e... | 02/04/2003 |
| 6511968 | Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions The invention provides a method for treating, preventing, or reducing the risk of developing a condition selected from the group consisting of acute coronary ischemic syndrome, thrombosis, thromboembolism, thrombotic occlusion and reocclusion, restenosis,... | 01/28/2003 |
| 6462064 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, th... | 10/08/2002 |
| 6455546 | Method for promoting ovulation, parturition, and lactation in mammals The present invention generally relates to various methods for promoting ovulation, parturition and lactation in female mammals. These benefits are obtained by administering to the mammals a composition containing a D2 receptor antagonist that ... | 09/24/2002 |
| 6407137 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 06/18/2002 |
| 6391911 | Coadministration of lucanthone and radiation for treatment of cancer Disclosed is a method of treating a cancer of the central nervous system in a host including administering radiation to the host; and administering lucanthone to the host; wherein the radiation and lucanthone are administered in amounts effective to cause... | 05/21/2002 |
| 6387892 | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme... | 05/14/2002 |
| 6384045 | Tricyclic and tetracyclic pyrones This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple con... | 05/07/2002 |
| 6353018 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 03/05/2002 |
| 6313107 | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme... | 11/06/2001 |
| 6258836 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 07/10/2001 |
| 6245797 | Combination therapy for reducing the risks associated with cardio-and-cerebrovascular disease The instant invention provides a drug combination comprised of an HMG-CoA reductase inhibitor in combination with a COX-2 inhibitor, which is useful for treating, preventing, and/or reducing the risk of developing atherosclerosis and atherosclerotic disea... | 06/12/2001 |
| 6172058 | Compounds with pharmaceutical properties A pharmaceutical compound of the formula ##STR1## in which R1 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-10 alkyl, C3-10 cyclo... | 01/09/2001 |
