Bizarre Patents
Crispy Chip Sandwich and Process of Producing a Sandwich Product
A food product comprising a multilayer cookie or snack having outer layers formed from a crispy type edible food product such as a potato chip or corn chip, etc. with an intermediate marshmallow layer being in contact with the inner surface of each crispy chip and one or more filler substances.
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| Number | Title | Issue Date |
| 8188055 | Inactivators of O6-alkylguanine-DNA alkyltransferase Disclosed are compounds that are AGT inactivators that include a folate residue, e.g., a compound of formula (I), wherein X1, X2, R1, and R2 are as described herein. Also disclosed is a pharmaceutical composition comprisin... | 05/29/2012 |
| 8183216 | Nucleoside derivatives as inhibitors of viral polymerases A class of nucleoside derivatives of formula (I), as defined herein, that are useful as inhibitors of RNA-dependent RNA viral replication and in particular HCV replication, are provided. Also provided are processes for the synthesis and use of such compounds for tre... | 05/22/2012 |
| 8178502 | Effective treatment of esophogeal adenocarcinoma using triciribine and related compounds The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described b... | 05/15/2012 |
| 8133872 | Use of nicotinic acid adenine dinucleotide phosphate or derivative thereof as agent for treating type-2 diabetes The administration of nicotinic acid adenine dinucleotide phosphate (NAADP) or a pharmaceutically acceptable salt thereof to a host in need thereof for the treatment of type-2 diabetes has been disclosed. ... | 03/13/2012 |
| 8114847 | Selective inhibitors of translesion DNA replication An agent for inhibiting translesion DNA replication comprises a non-natural adenine ribose analog represented by those as set forth in FIG. 1. ... | 02/14/2012 |
| 8106023 | 1,4-benzothiepin-1, 1-dioxide derivatives with improved properties method for producing the same, drugs containing said compounds and the use thereof This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof. ... | 01/31/2012 |
| 8106022 | Carbohydrate conjugates as delivery agents for oligonucleotides The present invention provides iRNA agents comprising at least one subunit of the formula (I): wherein: A and B are each independently for each occurrence O, N(RN) or S; | 01/31/2012 |
| 8101583 | 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof. ... | 01/24/2012 |
| 8097595 | Modulation of telomere length in telomerase positive cells and cancer therapy Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow... | 01/17/2012 |
| 8093220 | Combination of an HDAC inhibitor and an antimetabolite The invention relates to a combination which comprises: (a) a HDAI; and (b) an anti-metabolite, for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of proliferati... | 01/10/2012 |
| 8088746 | Bis-modified bicyclic nucleic acid analogs The present disclosure describes bis-modified bicyclic nucleosides and oligomeric compounds that can be prepared comprising at least one of these bis-modified bicyclic nucleosides. More particularly, the bis-modified bicyclic nucleosides have at least one substituen... | 01/03/2012 |
| 8076303 | Nucleotide and oligonucleotide prodrugs The present invention discloses compounds of formula (I): which exhibit antiviral properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration t... | 12/13/2011 |
| 8048862 | Macrocyclic inhibitors of hepatitis C virus replication The embodiments provide compounds of the general Formulae I, II, III, IV, V, VI, VII, and X, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treati... | 11/01/2011 |
| 7994142 | Agents containing folic acid, vitamin B6 and vitamin B12, and the use thereof The invention relates to agents that contain folic acid, vitamin B6 and vitamin B12, and to the use thereof in hyperhomocysteinemia for controlling homocysteine levels. The agents are mainly suitable for the preventive and acute treatment of vascular diseases, of pr... | 08/09/2011 |
| 7994143 | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and ... | 08/09/2011 |
| 7985738 | Cytosine nucleoside analogs and isoflavones and uses thereof Methods, uses, compositions and kits relating to the inhibition and/or prevention of undesirable cell proliferation, and prevention and/or treatment of diseases or disorders associated with such proliferation, such as cancer, using a cytosine nucleoside analog such ... | 07/26/2011 |
| 7977320 | Method of increasing efficacy of tumor cell killing using combinations of anti-neoplastic agents The present invention provides compositions and methods for increasing the amount of active Syk protein kinase and or SHP-1 protein phosphatase in a cell. The compositions and methods are useful for increasing the efficacy of anti-neoplastic agents, such as those th... | 07/12/2011 |
| 7935674 | Indole derivatives Novel indole derivatives of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 is halogen, or alkyl, R2 is hydrogen, or halogen, Ar is phenyl, or thienyl, which may be substituted wi... | 05/03/2011 |
| 7928080 | Indole antiviral compositions and methods The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as... | 04/19/2011 |
| 7910561 | Inhibitors of Akt activity The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this inventio... | 03/22/2011 |
| 7884081 | Methods of modulating tubulin deacetylast activity The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a... | 02/08/2011 |
| 7842672 | Phosphonate inhibitors of HCV A compound of Formula I, Formula II, Formula III, or Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, therapeutic compositions containing such compounds, and therapeutic methods that include... | 11/30/2010 |
| 7825096 | O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs Disclosed are prodrugs of inactivators of O6-alkylguanine-DNA alkyltransferase (AGT). The prodrugs are cleavable by the β-glucuronidase enzyme, which is either administered to the patient or produced by necrotic tumor cells. The prodrugs are represented ... | 11/02/2010 |
| 7820631 | Anti-viral pyrimidine nucleoside analogues A nucleoside analogue compound is provided which has a six-membered aromatic ring system, the aromatic ring system being substituted in the para position with an unbranched unsubstituted alkyl or alkoxy moiety, wherein the alkyl or alkoxy moiety, in total, has from ... | 10/26/2010 |
| 7816333 | Oligonucleotide analogues and methods utilizing the same A method for the prevention or treatment in a mammal of a disease preventable or treatable by the pharmacologically useful antisense or antigene activity of an oligonucleotide analogue or a pharmacologically acceptable salt thereof in the body of said mammal, which ... | 10/19/2010 |
| 7772198 | CFTR channel modulators The invention concerns pharmaceutical formulas designed for the treatment of diseases related to CFTR channel dysfunction, such as cystic fibrosis, asthma or diarrhoea. These formulas contain a molecule, coming in the form of a zwitterion at physiological pH, with t... | 08/10/2010 |
| 7772197 | 1,3,5-triazines for treatment of viral diseases The present invention provides compounds and methods for treatment of viral diseases and cancer. ... | 08/10/2010 |
| 7772199 | Forms of 5-azacytidine The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also include... | 08/10/2010 |
| 7741296 | Modulation of telomere length in telomerase positive cells and cancer therapy Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow... | 06/22/2010 |
| 7723310 | Large dose ribavirin formulations The present invention is related to pharmaceutical dosage forms of ribavirin which are designed to increase patient compliance to a ribavirin therapy. Examples of such dosage forms include 400 mg to 600 mg tablets. These dosage forms are bioequivalent to multiple do... | 05/25/2010 |
| 7718622 | Compositions comprising structurally stable conjugate molecules The present invention provides compositions comprising conjugate molecules that are structurally stable at a temperature of between about 2 degrees C. and 8 degrees C. In some examples, a conjugate molecule comprises an antigen, such as an allergen. In some examples... | 05/18/2010 |
| 7713941 | Tricyclic nucleosides or nucleotides as therapeutic agents Nucelosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively. ... | 05/11/2010 |
| 7709448 | Prodrugs of 5-amino-3-(3′-deoxy-β-D-ribofuranosyl)-thiazolo[4,5-]pyrimidin-2,7-dione The invention is directed to 5-amino-3-(3′-deoxy-β-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione prodrugs, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical... | 05/04/2010 |
| 7709449 | Nucleic acid-based compounds and methods of use thereof The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units. ... | 05/04/2010 |
| 7700567 | Oligonucleotide analogues incorporating 5-aza-cytosine therein Oligonucleotide analogues are provided that incorporate 5-aza-cytosine in the oligonucleotide sequence, e.g., in the form of 5-aza-2′-deoxycytidine (decitabine) or 5-aza-cytidine. In particular, oligonucleotide analogues rich in decitabine-deoxyguanosine islets (D... | 04/20/2010 |
| 7642247 | 1,3,5-triazines for treatment of viral diseases The present invention provides compounds and methods for treatment of viral diseases and cancer. ... | 01/05/2010 |
| 7638496 | Nucleoside analogs with carboxamidine modified monocyclic base Novel nucleoside analog compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, an infestation, a neoplasm, or an autoimm... | 12/29/2009 |
| 7632821 | Ribonucleoside cyclic acetal derivatives for the treatment of RNA-dependent RNA viral infection The present invention provides ribonucleoside 2′,3′-cyclic acetals of structural formula I which are precursors or prodrugs of inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors of inhibitors of RNA-dependent RNA viral replication a... | 12/15/2009 |
| 7629320 | Nucleoside derivatives for treating hepatitis C virus infection Disclosed are β-D-ribofuranosyl-pyrazolo[3,4-d]pyrimidine compounds, compositions and methods for treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Representative compounds include those having the general formula. | 12/08/2009 |
| 7625871 | Indole antiviral compositions and methods The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as... | 12/01/2009 |
