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Vladimir Zworykin, television pioneer ; Talking about an invention in which he played a critical role.
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| Number | Title | Issue Date |
| 8173695 | Kappa selective opioid receptor antagonist A selective kappa opioid receptor antagonist useful for treating ethanol use disorder withdrawal and anxiety, and/or depression, or schizophrenia as independent comorbid conditions. ... | 05/08/2012 |
| 7709522 | Kappa selective opioid receptor antagonist A selective kappa opioid receptor antagonist, (S)-3-Fluoro-4-[4-[2-(3,5-dimethylphenyl)pyrrolidin-1-yl-methyl]phenoxy]benzamide or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, and anxiety and/or depression, or schi... | 05/04/2010 |
| 7687536 | Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics Aminocycloalkyl cinnamide compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the trea... | 03/30/2010 |
| 7569599 | Intermediates for the production of optically active cyclopropylamine derivatives and process for the production of the intermediates A process for producing an optically active compound represented by formula (4), or a salt thereof, wherein R1 represents a protecting group. ... | 08/04/2009 |
| 7504432 | Ester derivatives This invention relates to compounds which exhibit selective muscarinic M3 receptor antagonism, have little side effects, are suitable for inhalation therapy and are useful as treating agents of respiratory system diseases, of the general formula (I); ... | 03/17/2009 |
| 7423059 | Pharmaceutically active compounds and methods of use The present invention relates to certain imine-substituted heterocyclic compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or p... | 09/09/2008 |
| 7419936 | Optically active 2,5-bisaryl-Δ-pyrrolines and their use as pest control agents Novel optically active Δ1-pyrrolines of the formula (I) in which R1, R2, R3, R4, and m are each as defined in the description, a plurality of... | 09/02/2008 |
| 7408071 | N-aryl pyrrolidine derivatives as beta-secretase inhibitors There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R... | 08/05/2008 |
| 7399773 | Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid and phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ... | 07/15/2008 |
| 7396828 | PI-3 kinase inhibitor prodrugs The invention provides prodrugs of inhibitors of PI-3 kinase. The compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine. ... | 07/08/2008 |
| 7368462 | Melanin concentrating hormone antagonists The present invention relates to compounds capable of serving as moderators of human and mammalian appetite and as such provide a means for reducing body mass and controlling obesity. ... | 05/06/2008 |
| 7348356 | Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's dis... | 03/25/2008 |
| 7345082 | Phosphinic acids The present invention relates to phosphinic acid derivatives of formula I wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prev... | 03/18/2008 |
| 7332516 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is â€... | 02/19/2008 |
| 7329762 | Prodrugs of mitotic kinesin inhibitors The present invention relates to phosphate ester prodrugs of dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relate... | 02/12/2008 |
| 7323490 | Pyrrole compounds and uses thereof The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The compounds and compositions disclosed herein are preferably used in the treat... | 01/29/2008 |
| 7323492 | 7-pyrollyl 9-aminoacyl tetracycline compounds and methods of use thereof A compound of formula (I): wherein: A represents an aromatic 5 membered heterocycle, optionally containing, in addition to the nitrogen atom indicated in formula (I), one to thr... | 01/29/2008 |
| 7294647 | Kappa agonist compounds and pharmaceutical formulations thereof Compounds having kappa opioid agonist activity, compositions containing them and 5 method of using them as analgesics and pruritic agents are provided. The compounds of formulae I, II, III and IV have the structure: ... | 11/13/2007 |
| 7256210 | 7-amido-isoindolyl compounds and methods of their use The invention encompasses 7-amido-isoindolyl compounds and methods of using these compounds and compositions in mammals for treatment, prevention or management of various diseases and disorders. Examples include, but are not limited to, cancer, inflammatory bowel di... | 08/14/2007 |
| 7235580 | Mitotic kinesin inhibitors The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which c... | 06/26/2007 |
| 7223744 | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor agonist to stimulate the removal of pathological extraneous fluid from... | 05/29/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7199081 | Aqueous compositions for seed treatment An aqueous composition suitable for applying fungicides to plant propagation materials is provided, comprising water and a blend of the following components, by weight: a) 2–10% of a surface-active agent comprising a1) at least one anionic surfactant;... | 04/03/2007 |
| 7176229 | Cyclic AMP-specific phosphodiesterase inhibitors Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as c... | 02/13/2007 |
| 7173058 | Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses The invention encompasses novel compounds, pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomers, racemates, or mixtures of stereoisomers thereof, pharmaceutical compositions of these compounds, and methods of using these comp... | 02/06/2007 |
| 7160902 | Amide derivatives and methods of their use Amide derivatives of the general formulae Ia and Ib: are disclosed. Pharmaceutical compositions containing these compounds, and methods for their use, inter alia, for treating and/or preventing gastrointestinal d... | 01/09/2007 |
| 7144881 | Arylcyclopropylcarboxylic amides as potassium channel openers The present invention provides novel arylcyclopropylcarboxylic amides and related derivatives having the general Formula I wherein R, R1, R2, R3, R4, R5, R | 12/05/2006 |
| 7105507 | Cyclohexane derivatives and their use as therapeutic agents The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R | 09/12/2006 |
| 7074785 | Δ-pyrrolines used as pesticides Novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, A, R4 and m have the meanings given in the description, a number of proce... | 07/11/2006 |
| 7056945 | Selective inhibition of neuronal nitric oxide synthase Compositions, prodrugs and methods for inhibiting neural Nitric Oxide Synthase (nNOS). By inhibiting nNOS, the compounds, prodrugs and methods of the presnet invention are useable to treat or prevent disorders in human or veterinary patients that are caused, mediate... | 06/06/2006 |
| 7057053 | Ion channel modulating compounds and uses thereof Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatme... | 06/06/2006 |
| 7053087 | Aminocycloalkyl cinnamide compounds for arrhythmia and analgesics and anesthetics Aminocycloalkyl cinnamide compounds (I) are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the ... | 05/30/2006 |
| 7034051 | Fused bicyclic carboxamide derivatives and methods of their use Fused bicyclic carboxamide derivatives are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. ... | 04/25/2006 |
| 7034045 | Monofluoroalkyl derivatives The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. ... | 04/25/2006 |
| 7034052 | 7-Amido-isoindolyl compounds and their pharmaceutical uses The invention encompasses 7-amido-isoindolyl compounds and methods of using these compounds and compositions in mammals for treatment, prevention or management of various diseases and disorders. Examples inlcude, but are not limited to, cancer, inflammatory bowel di... | 04/25/2006 |
| 7026440 | Branched polymers and their conjugates The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at le... | 04/11/2006 |
| 6995185 | Δ1-pyrrolines used as pesticides Novel Δ1-pyrrolines of the formula (I) in which Ar1, Ar2 and Q are each as defined in the description, a plurality of processes for preparing these substances... | 02/07/2006 |
| 6992193 | Sulfonylamino phenylacetamide derivatives and methods of their use Sulfonylamino phenylacetamide derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. In certain embodiments, the compounds o... | 01/31/2006 |
| 6989088 | Perfluorocyclicamine, constant boiling composition and process for producing the same A process for producing a perfluorocyclicamine which includes electrolytically fluorinating a triallylamine in anhydrous liquid hydrogen fluoride. A constant boiling composition and process for producing the same is also described. ... | 01/24/2006 |
| 6960612 | Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith Methods for prevention or treatment of pruritus are provided. The methods comprise administering to a patient an effective amount of a kappa opioid receptor agonist compound. The involved kappa opioid receptor agonist compounds are of the type represented by the fol... | 11/01/2005 |
