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| Number | Title | Issue Date |
| 8168674 | Method for treating bronchial diseases Administration of a loop diuretic in nebulized dry powder form directly to a patient's lungs for treating bronchial disease. ... | 05/01/2012 |
| 8163794 | Crystalline form of a 3-phenoxymethylpyrrolidine compound The invention provides a crystalline hydrochloride salt of (S)-3-[(S)-1-(4-chlorophenoxy)-2-methylpropyl]pyrrolidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline ... | 04/24/2012 |
| 8158673 | Histamine-3 receptor antagonists This invention is directed to a compound of formula I, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a process of preparation of a compoun... | 04/17/2012 |
| 8106090 | 1-amino linked compounds The present invention is directed to compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein A is (II); X is selected from CH, CF and N, R8 is selected from H, C1-C6 alkyl, aryl, heteroaryl, C1-C6 ... | 01/31/2012 |
| 8063098 | GlyT1 receptor antagonists The present invention relates to a compound of formula I wherein R1, R2, X, Ar1 and Ar2 are as defined herein and to pharmaceutically acceptable... | 11/22/2011 |
| 8048910 | Combination of R,R-glycopyrrolate, rolipram, and budesonide for the treatment of inflammatory diseases Novel combinations based on anticholinergics, β2-adrenoceptor agonists, PDE 4 Inhibitors, glucocorticoids, and leukotriene-receptor antagonists, process for their production and their use for the treatment of inflammatory diseases, preferably respiratory... | 11/01/2011 |
| 8030344 | Inhibitors of histone deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and cond... | 10/04/2011 |
| 7999000 | N-(2-amino-phenyl)-acrylamides The present invention is directed to the compounds of formula wherein R1 to R4 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing ... | 08/16/2011 |
| 7888386 | 3-(phenoxyphenylmethyl)pyrrolidine compounds In one aspect, the invention relates to compounds of formula I: where a and R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and no... | 02/15/2011 |
| 7825156 | Method of treating bipolar depression with a benzamide derivative A benzamide derivative, especially amisulpride, is used to prevent or treat bipolar depression of a patient suffering from bipolar disorder I or bipolar disorder II. ... | 11/02/2010 |
| 7807708 | Ligands that modulate RAR receptors and pharmaceutical/cosmetic compositions comprised thereof Novel ligand compounds having the general formula (I): and pharmaceutical/cosmetic compositions comprised thereof are useful in human and veterinary medicine or, alternatively, in cosmetics. ... | 10/05/2010 |
| 7807709 | Organic compounds The invention relates to the use of (3,4-di-, 3,3,4-tri, 3,4,4-tri- or 3,3,4,4-tetra-)substituted pyrrolidine compounds for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of tha... | 10/05/2010 |
| 7776910 | Arylsulfonyl pyrrolidines as 5-HTinhibitors Compounds of the formula I: wherein m, n, Ar, R1 and R2 are as defined herein. Methods of making the compounds and using the compounds are disclosed. ... | 08/17/2010 |
| 7741364 | Pyrrole derivatives and their methods of use The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions. ... | 06/22/2010 |
| 7723377 | Inhibitors of cognitive decline Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and Alzheimer's disease with a derivativ... | 05/25/2010 |
| 7659306 | Method of increasing gastric emptying The invention discloses the administration of nafadotride partially reverse the effect of dopamine on gastric emptying in patients suffering from gastroesophageal reflux. ... | 02/09/2010 |
| 7632858 | Open chain prolyl urea-related modulators of androgen receptor function The invention provides for a pharmaceutical composition capable of modulating the androgen receptor comprising a compound of formula I wherein R1, R2, R3, X, Y, Z and G are as described here... | 12/15/2009 |
| 7524880 | Crystalline form of a substituted pyrrolidine compound The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of 2-[(S)-1-(8-methylaminooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide or a solvate thereof. This invention also provides pharmaceutical compositions comprising the salt or prepared using the ... | 04/28/2009 |
| 7504431 | Sulfonyl amide inhibitors of calcium channel function Compounds of formula I its stereoisomers, solvates, and salts, thereof, wherein: a, b, c, d, f, n, m and Ra are defined herein are are inhibitors of calcium channel function, and are useful in treating calcium channel-depen... | 03/17/2009 |
| 7470718 | Method for treating a demyelinating condition Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca2+-channel blocker effective to treat the demyelinating condition. In other ... | 12/30/2008 |
| 7419936 | Optically active 2,5-bisaryl-Δ-pyrrolines and their use as pest control agents Novel optically active Δ1-pyrrolines of the formula (I) in which R1, R2, R3, R4, and m are each as defined in the description, a plurality of... | 09/02/2008 |
| 7420000 | Amino phosphonate and amino bis-phosphonate derivatives Aminophosphonate and amino bisphosphonate compounds and methods for their preparation are provided. Also provided are pharmaceutical and agricultural compositions containing the compounds. The compounds and compositions are useful in methods for treatment of various... | 09/02/2008 |
| 7417062 | Substituted arylamides Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer. ... | 08/26/2008 |
| 7402684 | Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: | 07/22/2008 |
| 7399748 | Antitumor therapy comprising distamycin derivatives The present invention relates to an administration schedule comprising the intravenous administration of a α-halogen-acryloyl distamycin derivative, or a pharmaceutically acceptable salt thereof. The above administration allows the treatment of a variety of tumors ... | 07/15/2008 |
| 7396854 | Use of serotonergic compound for a method of treatment of hot flushes in post-menopausal women The present invention relates to a method of treatment of hot flushes with a 5-HT2C receptor agonist and in particular to the use of the selective 5-HT2C receptor agonists 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-piperazine and (S)-(+)-3-[(... | 07/08/2008 |
| 7393864 | Use of ClC3 chloride channel blockers to modulate vascular tone The present invention provides methods for the modulation of vascular tone in a patient having compromised vascular tissue, which methods comprise the administration of a chloride channel blocking agent or a pharmaceutically acceptable salt thereof. ... | 07/01/2008 |
| 7381742 | Optically active polymaleimide derivatives and process for their production Optically active maleimide derivatives of the formula: (where the various substituents are as defined in the description) are used as separating media for separating optical isomers and geometrical isomers such as by high p... | 06/03/2008 |
| 7358274 | Methods for treating or preventing cancer using Benzopyranone Compounds This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or neoplastic cell comprising administering an effective amount of a Benzopyra... | 04/15/2008 |
| 7358374 | Purified racemic lasofoxifene and purified lasofoxifene D-tartrate and a method for effective purification of racemic lasofoxifene A method for removing impurities from racemic cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol and purified cis-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol useful as an estrogen agonist/antagon... | 04/15/2008 |
| 7351719 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover t... | 04/01/2008 |
| 7351825 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/01/2008 |
| 7351717 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer ... | 04/01/2008 |
| 7351718 | Substituted pyrrolidine and related compounds This invention is directed to compounds of formula I: wherein R1-R5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer ... | 04/01/2008 |
| 7348356 | Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's dis... | 03/25/2008 |
| 7335659 | Substituted 10-aryl-11-benzo[]fluorenes and 7-aryl-5, 6-dihydro-benzo[]anthracenes for selective effects on estrogen receptors This invention provides a compound, or its possible salt, having the formula, wherein: Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2CH2— or... | 02/26/2008 |
| 7335680 | Pyrrolidine derivatives as prostaglandin modulators Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm la... | 02/26/2008 |
| 7335681 | Amino ceramide-like compounds and therapeutic methods of use Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer sy... | 02/26/2008 |
| 7329654 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their prepar... | 02/12/2008 |
| 7323490 | Pyrrole compounds and uses thereof The invention provides pyrrole-containing compounds and methods of use thereof. Kits and pharmaceutical compositions comprising the pyrrole compounds of the invention are also provided. The compounds and compositions disclosed herein are preferably used in the treat... | 01/29/2008 |
