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| Number | Title | Issue Date |
| 8188140 | Uses of ion channel modulating compounds Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods, the disease or condition is treated or prevented by administering one ... | 05/29/2012 |
| 8178576 | Non-polymeric lipophilic pharmaceutical implant compositions for intraocular use Solid or semi-solid intraocular implant compositions are disclosed. The compositions contain a lipophilic compound but lack a polymeric ingredient. ... | 05/15/2012 |
| 8097647 | Augmented cognitive training The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors. ... | 01/17/2012 |
| 8071639 | Soft anticholinergic zwitterions Soft anticholinergic zwitterions of the formulas: wherein R1 and R2 are both phenyl or one of R1 and R2 is phenyl and the other is cyclopentyl; and wherein each asterisk marks a c... | 12/06/2011 |
| 8067458 | Alkoxyalkyl-substituted cyclic ketoenols The invention relates to new alkoxyalkyl-substituted cyclic ketoenols of the formula (I) in which A, B, D, G, W, X and Y have the definitions indicated above, to processes and intermediates for the... | 11/29/2011 |
| 8058305 | Pyrrolidine derivatives as prostaglandin modulators Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm la... | 11/15/2011 |
| 8058304 | Merged ion channel modulating compounds and uses thereof Merged compounds of ion channel modulating compounds, including, for example, merged compounds of the ion channel modulating compound of the following formula: (I) are described herein, as well as methods of making and using such merged compounds and pharmaceutical ... | 11/15/2011 |
| 8048908 | 11β-hydroxysteroid dehydrogenase type 1 active compounds The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a novel class of substituted amides, of the general formula I. Their u... | 11/01/2011 |
| 8026273 | 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the comp... | 09/27/2011 |
| 8022098 | Deuterated aminocyclohexyl ether compounds and processes for preparing same This invention is directed to deuterated aminocyclohexyl ether compounds and processes for preparing same and methods of using same. ... | 09/20/2011 |
| 8013008 | Cyclic amine compound A compound represented by the formula (I) each symbol of which is defined in the specification, or a salt thereof which has a superior androgen receptor regulating activity. ... | 09/06/2011 |
| 8008342 | Ion channel modulating compounds and uses thereof Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatme... | 08/30/2011 |
| 8008341 | Pharmaceutically active benzsulfonamide derivatives as inhibitors of protein junkinases The present invention relates to benzsulfonamide derivatives of formula I and methods of use thereof. The benzsulfonamide derivatives of the present invention are efficient modulators of the JNK pathway. In particular the benzsulfonamide derivatives of the present i... | 08/30/2011 |
| 7998999 | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 The present invention discloses novel compounds of Formula I: having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, a... | 08/16/2011 |
| 7985766 | Combination of anticholineric and β mimetics for the treatment of respiratory diseases The present invention describes a combination of an anticholinergic, such as R,R-glycopyrrolate, and a β mimetic, such as tormoterol, for the treatment of respiratory diseases including airway inflammation or obstruction such as chronic obstructive pulmonary diseas... | 07/26/2011 |
| 7981923 | Tetralin and indane derivatives and uses thereof Compounds of the formula I, II or III: or pharmaceutically acceptable salts thereof, wherein m, n, q, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also pr... | 07/19/2011 |
| 7977373 | Prodrugs of ion channel modulating compounds and uses thereof Prodrugs of ion channeling modulating compounds, including, for example, prodrugs of the ion channel modulating compound of the following formula: are described herein, as well as methods of making and using such prodrugs and pharmaceutical compositions containing s... | 07/12/2011 |
| 7968592 | 3-aminopyrrolidone derivatives 3-aminopyrrolidone compounds and pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to cardiovascula... | 06/28/2011 |
| 7960429 | Kappa-opiate agonists for the treatment of diarrhea-predominant irritable bowel syndrome The present invention concerns methods useful in treating a subject having diarrhea-predominant IBS (IBS-D) by administering N methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide and/or a pharmaceutically acceptable salt thereof to ... | 06/14/2011 |
| 7947731 | Augmented cognitive training The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal acti... | 05/24/2011 |
| 7919520 | Inhibitors of tace The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases. ... | 04/05/2011 |
| 7915303 | Glycopyrronium salts and their therapeutic use A glycopyrronium salt such as glycopyrronium iodide has a lower glass transition temperature than glycopyrronium bromide. It is therefore more suitable for formulation. ... | 03/29/2011 |
| 7863317 | Lactams of alkylated acyclic diamine derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis. | 01/04/2011 |
| 7820712 | Uses of ion channel modulating compounds Methods, formulations, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias, including the treatment or prevention of atrial fibrillation. In these methods, the disease or condition is treated or prevented by administering one ... | 10/26/2010 |
| 7816396 | Method for increasing the bioavailability of glycopyrrolate The invention relates to a method of treating sialorrhea in a human patient, which comprises orally administering glycopyrrolate in a liquid solution to the human patient under fasted conditions. ... | 10/19/2010 |
| 7816395 | Pyrrolidinone anilines as progesterone receptor modulators The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a combination thereof, wherein R1, R2, and X ar... | 10/19/2010 |
| 7799823 | Androgen modulators The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth. ... | 09/21/2010 |
| 7754758 | Pyrrolidine derivatives acting as CCR3-receptor antagonists Compounds of formula I in free or salt form, wherein T, X, Y, U, R1, R2, m, n and p have the meanings as indicated in the specification, are useful for treating conditions mediated by CCR3. Pharmaceuti... | 07/13/2010 |
| 7732481 | Prolinylarylacetamides Novel compounds of the formula (I), in which R, R1, R2, R3, X, X′ and Y have the meaning indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboe... | 06/08/2010 |
| 7705036 | Deuterated aminocyclohexyl ether compounds and processes for preparing same This invention is directed to deuterated aminocyclohexyl ether compounds and processes for preparing same and methods of using same. ... | 04/27/2010 |
| 7696243 | Pyrrolidin-2-one derivatives for use as DPreceptor agonists The present invention is directed to compounds that may be used as agonists of prostaglandin receptors. More specifically, the specification describes methods and compositions for making and using DP1 receptor agonists that are pyrrolidin-2-one derivatives. ... | 04/13/2010 |
| 7683094 | 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the comp... | 03/23/2010 |
| 7678827 | Non-polymeric lipophilic pharmaceutical implant compositions for intraocular use Solid or semi-solid intraocular implant compositions are disclosed. The compositions contain a lipophilic compound but lack a polymeric ingredient. ... | 03/16/2010 |
| 7674820 | Ion channel modulating activity I Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating comp... | 03/09/2010 |
| 7638552 | Method for increasing the bioavailability of glycopyrrolate The invention relates to a method of increasing the bioavailability of glycopyrrolate by administration of a therapeutically effective amount of glycopyrrolate without food. The invention also provides a kit comprising a pharmaceutical composition comprising a thera... | 12/29/2009 |
| 7635713 | Pyrrolidine derivatives as prostaglandin modulators Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm la... | 12/22/2009 |
| 7625941 | Ionic liquids The present invention relates to compositions of matter that are useful as ionic liquids. The compositions of the invention are based on an N-substituted pyrrolidinone, said pyrrolidinone having a pendant ammonium cation that is separated from the pyrrolidone ring b... | 12/01/2009 |
| 7608636 | Medicines for treatment and prevention of neurogenic pain A medicament for therapeutic and/or prophylactic treatment of neuropathic pain, which comprises a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherei... | 10/27/2009 |
| 7608637 | Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as the active ingredient A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing... | 10/27/2009 |
| 7601753 | Pyrrolidine melanocortin-specific compounds Melanocortin receptor-specific pyrrolidine compounds having the structure: and stereoisomer and pharmaceutically acceptable salts thereof, where R1, R2, and R3 are as described in the specif... | 10/13/2009 |
