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| Number | Title | Issue Date |
| 8183280 | FAP inhibitors The present invention concerns compounds, according to general formula (I), which find utility preferably for the treatment of cancer. ... | 05/22/2012 |
| 8163793 | Proline derivatives The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament. ... | 04/24/2012 |
| 8148419 | N-(1-alkyl-2-phenylethyl)-carboxamide derivatives and use thereof as fungicides A compound of general formula (I): A process for preparing this compound. A fungicidal composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general for... | 04/03/2012 |
| 8143306 | Methods of treating bipolar disorders The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, useful in the treatment of diseases and conditions mediated by modulation of use-dependent voltage-gated sodium channels. Methods of treating and moderating one or more bipolar d... | 03/27/2012 |
| 8119684 | Thiophene derivatives for up-regulating HLA-DM activity Compounds of formula (I), compositions, methods and kits are provided. The compounds and compositions may be particularly useful for modulating immunological responses. Formula (I) wherein, R1 is alkyl, aryl, or heterocyclyl; R2 is H, alkyl, ar... | 02/21/2012 |
| 8110598 | Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine The present invention relates to novel substituted pyrrole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceuti... | 02/07/2012 |
| 8106089 | Anti-tubulin acting arylpyrrol, arylfuran and arylthiophene derivatives, method for the preparation thereof and for the use thereof as an antimitotic The invention relates to a compound represented by general formula (I) wherein Z represents N, O or S, and A represents a CH group, a nitrogen atom or an NL+ group wherein L represents a straight-chained or branched C1-C12 alkyl grou... | 01/31/2012 |
| 8101650 | Method for treating a immunology-related disease A method for treating an immunology-related disease. The method involves administering to a mammal in need thereof a pharmaceutically effective amount of an amino acid compound, a pharmacologically acceptable salt thereof or a pharmacologically acceptable ester ther... | 01/24/2012 |
| 8088818 | Catechol-based derivatives for treating or preventing diabetics The present invention provides a catechol-based derivative and a pharmaceutical acceptable salt therefrom and a solvate therefrom. A pharmaceutical composition for preventing or treating diabetics and ischemics, comprising a catechol-based derivative of formula (I) ... | 01/03/2012 |
| 8084488 | Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid magnesium Novel forms of atorvastatin magnesium salt designated Form A, Form B, Form C, Form D, Form E, and Form F, pharmaceutical compositions containing such compounds, methods for their preparation and methods utilizing the compounds for treatment of hyperlipidemia, hyperc... | 12/27/2011 |
| 8080579 | Compositions and methods for treatment of inflammatory bowel disease The present invention provides compositions and methods for treating inflammatory bowel disease. In particular, the present invention provides methods of therapeutically treating symptoms of inflammatory bowel disease using compositions comprising an angiotensin con... | 12/20/2011 |
| 8071638 | Solid states of atorvastatin potassium Atorvastatin potassium crystalline Forms A, B, E, F, and G are provided. Also provided are methods of preparing atorvastatin potassium crystalline Forms A, B, E, F, and G. Atorvastatin potassium crystalline Forms A, B, E, F, and G may be used to prepare pharmaceutic... | 12/06/2011 |
| 8063097 | Compositions and methods for regulating mammalian keratinous tissue Skin care compositions and methods for regulating the condition of mammalian keratinous tissue containing an effective amount of a dipalmitoyl hydroxyproline salt and a second skin care compound selected from hexamidine compounds, sugar amine compounds and their com... | 11/22/2011 |
| 8053464 | Attractants for insects such as flies A composition containing at least two members of the group consisting of propionic acid, benzoic acid, 2,6-dimethoxyphenol, 2-acetylpyrrole, 2-hydroxy-3-methyl-2-cyclopentanone, 2-methyltetrahydrofuran-3-one, and 3-methylbutanal; and water, and optionally a carrier ... | 11/08/2011 |
| 8053465 | Bicycloester derivative Summary Novel bicycloester derivatives and pharmaceutically acceptable salts thereof have high DPP-IV inhibitory activity. Solving Means The novel bicycloester derivatives are represented by the general formula (1): | 11/08/2011 |
| 8048907 | Receptor antagonists and their methods of use The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds o... | 11/01/2011 |
| 8039507 | Therapeutic substituted gamma lactams Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt or a prodrug thereof; wherein Y, A, X, R and D are as described. Methods, compositions, and medicaments... | 10/18/2011 |
| 8026272 | Modified lysine-mimetic compounds Lysine mimetic compounds having useful pharmacological activity such as antiarrhythmic activity and desirable bioavailability properties are disclosed. ... | 09/27/2011 |
| 8003683 | Acetylated amino acids as anti-platelet agents, nutritional and vitamin supplements This invention relates to pharmaceutical compounds and nutritional supplements that are acetylated derivatives of naturally occurring amino acids and acetylated derivatives of peptides derived from naturally occurring amino acids containing hydroxyl groups. They are... | 08/23/2011 |
| 7977371 | Pyrrole derivative having ureido group and aminocarbonyl group as substituents Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medic... | 07/12/2011 |
| 7977372 | Ortho aminoamides for the treatment of cancer Compounds of formula are HDAC inhibitors. These compounds are useful for the treatment of diseases such as cancer in humans or animals. ... | 07/12/2011 |
| 7968591 | 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula I methods for their production, pharmaceutical compositions containing them, and the use thereof for noradrenalin receptor regulation, particular... | 06/28/2011 |
| 7964630 | Topical application agents against mimic and age-related wrinkles The compounds of formula (I) wherein X represents a bond or NH—CH(C═O)—(CH2)3+n—NH—R5, n represents 0, 1 or 2, R1, R4 a... | 06/21/2011 |
| 7951836 | Substituted phenyl methanone derivatives The present invention relates to compounds of formula I wherein R1, R2, R3, X, n, and m are as defined herein and to pharmaceutically acceptable acid addition salts thereof, to pharmaceutica... | 05/31/2011 |
| 7943659 | MAPK/ERK kinase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. ... | 05/17/2011 |
| 7943660 | Inhibitors of the LFA-1/ICAM-1 interaction and uses thereof The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions contain... | 05/17/2011 |
| 7935723 | Use of organic compounds A method for improving glucose control by administering metformin in combination with a DPP-IV inhibitor to a patient in need thereof, in an amount sufficient to control the glucose level over an extended period of time. ... | 05/03/2011 |
| 7923467 | Substituted pyrrole derivatives and their use as HMG-CO inhibitors The present invention relates to substituted pyrrole derivatives, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of c... | 04/12/2011 |
| 7915302 | Crystal forms of pyrrolylheptanoic acid derivatives The present invention provides novel crystalline forms D1 and D2 of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt, and hydrates thereof. The crystallin... | 03/29/2011 |
| 7910617 | Method for suppressing the number of peripheral blood lymphocytes using an amino alcohol compound A method for suppressing the number of peripheral blood lymphocytes involving administering to a human in need thereof a pharmaceutically effective amount of a compound which is (2R) -2-amino-2-methyl-4-{1-methyl-5-[4-(4-methylphenyl)butanoyl]pyrrol-2-yl}butan-1-ol ... | 03/22/2011 |
| 7906549 | Aminocarboxylic acid derivative and medicinal use thereof The present invention relates to a compound represented by the formula (I), a salt thereof, an N-oxide form thereof, a solvate thereof, or a prodrug thereof, and a medicament containing the same. The compound represented by the formula (I) has an ability to bind to ... | 03/15/2011 |
| 7906550 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they ac... | 03/15/2011 |
| 7902252 | Inhibitors of D-amino acid oxidase The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ... | 03/08/2011 |
| 7893103 | Processes for the preparation of DPP IV inhibitors The present invention relates to novel processes for preparing DPP-IV inhibitors having the structure of formula I, and pharmaceutically acceptable salt thereof, which are useful for treatment of Type 2 diabetes. ... | 02/22/2011 |
| 7888385 | Airway alkalinization as therapy for airway diseases The present invention relates to a method of treating asthma by raising the pH of the airways of an individual. The effect can be mediated directly by administering a pharmaceutically acceptable basic solution or alternatively, the effect can be mediated by enhancin... | 02/15/2011 |
| 7879902 | Pyrrole derivatives, intermediates therefor, preparation and therapeutic use thereof The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The in... | 02/01/2011 |
| 7863316 | Extended release formulation of Levetiracetam The present invention relates to extended release pharmaceutical compositions of Levetiracetam and processes for preparing the same. The extended release tablet of Levetiracetam is with a core comprising of Levetiracetam and water dispersible rate controlling polyme... | 01/04/2011 |
| 7846963 | 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease compri... | 12/07/2010 |
| 7842716 | Treating vascular events with statins by inhibiting PAR-1 and PAR-4 The present invention relates to new methods for treating and/or preventing vascular events by inhibiting G-coupled Protease Activating Receptor (PAR)-1 and/or PAR-4 with the administration of statins. In one embodiment, individuals who are at risk for vascular even... | 11/30/2010 |
| 7790763 | Substituted phenyl methanone derivatives The present invention relates to compounds of formula I wherein R1, R2, R3, n, and m, are as defined in the specification and to pharmaceutically acceptabl... | 09/07/2010 |
