Class 514/422 - Additional hetero ring

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter which contains an additional hetero ring,
No. of patents: 1754
Last issue date: 05/08/2012

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Number	Title	Issue Date
8173694	Therapeutic agent Provided are agents and methods for use in depleting serum amyloid P component (SAP) from a patient in need thereof. ...	05/08/2012
8163792	IAP BIR domain binding compounds Disclosed herein is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a prodrug, or a pharmaceutically acceptable salt, or labeled with a detectable label or an affinity tag there...	04/24/2012
8124648	Therapeutic lactams Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein J1, J2, B, Y, and A are as described. Methods, compositions, and medicaments related thereto are ...	02/28/2012
8088817	Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent A compound represented by the following formula (1) or a salt thereof: The compound has an inhibitory activity on the production of interleukin-6, and is therefore useful as a therapeutic agent for a disease associated with...	01/03/2012
8067457	Compounds useful as antagonists of CCR2 The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the tr...	11/29/2011
8063096	Spirocyclic 3-phenyl-3substituted-4-ketolactams and-lactones The present invention relates to novel phenyl-substituted 4-ketolactams and -lactones of the formula (I) in which A, B, Q, G, W, X, Y, Z and R3 are as defined above, to processes and intermedi...	11/22/2011
8063095	IAP BIR domain binding compounds Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B...	11/22/2011
8044092	Therapeutic compounds A compound having a substituted five or six-membered carbocycle or heterocycle directly bonded to a substituted aryl or heteroaryl ring, wherein said compound has an EC50 value of 20 nM or less at the prostaglandin EP2 receptor according to the...	10/25/2011
8022096	Pyrrolidine derivatives Pyrrolidine compounds described herein and methods for using them to inhibit dipeptidyl peptidase IV and treat Type II diabetes. ...	09/20/2011
8022097	Adamantane-dipyrromethane derivatives, method of preparation and applications in anion sensing Aamantane dipyrromethane derivatives are obtained by reacting adamantane carbonyl derivatives with pyrrole or pyrrole derivative, in the presence of acid. Adamantane-dipyrromethanes are used to bind anions of the group consisting of: F—, Cl—, Br—, acetate, HSO...	09/20/2011
8017647	Crystalline sodium atorvastatin Crystalline sodium atorvastatin, compositions containing the same and methods for the production thereof. ...	09/13/2011
7998998	Therapeutic substituted lactams Disclosed herein are compounds having a formula: (I) Compositions, methods, and medicaments related thereto are also disclosed. ...	08/16/2011
7985765	Therapeutic substituted pyrroles Disclosed herein is a compound represented by a formula: Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ...	07/26/2011
7973071	Substituted gamma lactams as therapeutic agents A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related to these compoun...	07/05/2011
7968590	IAP binding compounds IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in cells treated with such molecules. Embodiments of these compounds hav...	06/28/2011
7956084	Phenyl thiophene carboxamide compounds as inhibitors of the enzyme IKK-2 The invention relates to thiophene carboxamides of formula (I), wherein A, R1, R2, R3, n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them an...	06/07/2011
7947730	Piperidinium and pyrrolidinium derivatives as ligands for the muscarinic M3 receptor Compounds of formula I in salt or zwitterionic form wherein, wherein R1, R2, R3, R4, R5, J, L and M have the meanings as indicated in the specification, are useful for ...	05/24/2011
7915301	Inhibitors of cyclin dependent kinases and their use The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4...	03/29/2011
7897635	HIV protease inhibitors Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed. ...	03/01/2011
7884127	Inhibitors of cyclin dependent kinases and their use The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ic) wherein R1, R2, R3, R4	02/08/2011
7858657	Wortmannin analogs and methods of using same in combination with chemotherapeutic agents Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the wortmannin analogs may be administered with other chemotherapeutic a...	12/28/2010
7842715	N-benzoyl- and N-benzylpyrrolidin-3-ylamines as histamine-3 antagonists The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor. ...	11/30/2010
7803836	Aminophenylsulfonamide derivatives as HIV protease inhibitor The present invention concerns substituted aminophenylsulfonamide compounds and derivatives, their use as protease inhibitors, in particular as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnost...	09/28/2010
7799822	Phenyl sulfonamides as modulators of ion channels The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of variou...	09/21/2010
7799821	Therapeutic compounds A compound having a substituted five or six-membered carbocycle or heterocycle directly bonded to a substituted aryl or heteroaryl ring, wherein said compound has an EC50 value of 20 nM or less at the prostaglandin EP2 receptor according to the...	09/21/2010
7795298	IAP BIR domain binding compounds Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B...	09/14/2010
7781482	Substituted gamma lactams as therapeutic agents A compound comprising or a pharmaceutically acceptable salt thereof, or a prodrug thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments related to these compounds a...	08/24/2010
7776908	Wortmannin analogs and methods of using same Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well, as tumor formation in a subject are described herein. ...	08/17/2010
7759389	Chroman derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1, R2, R3 and R4 are as defined herein. Also provided are methods for pre...	07/20/2010
7737175	Methods and compositions for regulating HDAC4 activity The present invention provides methods and compositions for modulating HDAC4 activity and modulating the activity of proteins downstream of HDAC4 in the muscle transcriptional pathway in a cell by modulating HDAC4 activity. Further provided are methods and compositi...	06/15/2010
RE41356	Hepatitis C inhibitor tri-peptides Racemates, diastereolsomers and optical isomers of a compound of formula (I): wherein B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which optionally substituted with C	05/25/2010
7723375	Metabolites of wortmannin analogs and methods of using the same Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein. ...	05/25/2010
7718691	Compounds as inhibitors of hepatitis C virus NS3 serine protease The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us...	05/18/2010
7691897	Therapeutic agent Agent for the depletion of an unwanted protein population from the plasma of a subject, which agent comprises a plurality of ligands covalently co-linked so as to form a complex with a plurality of the proteins in the presence thereof, wherein at least two of the li...	04/06/2010
7652059	Pyrrolcarboxamides and pyrrolcarbothioamides The invention relates to novel pesticidal pyrrolcarboxamides of formula I wherein X is oxygen or sulfur; R1 is CF3, CF2H or CFH2; R2	01/26/2010
7652060	Small molecule rotamase enzyme inhibitors This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamas...	01/26/2010
7638550	Pyrrolic derivatives with histone deacetylase inhibitory activity The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to their inhibitory activity on certain histone deacetylases. ...	12/29/2009
7638549	Mitotic kinesin inhibitors The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which c...	12/29/2009
7632857	Histamine H3 receptor agents, preparation and therapeutic uses The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the inventio...	12/15/2009
7615573	Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis. ...	11/10/2009

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Class 514/422 - Additional hetero ring