Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 8008340 | 3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase I A method for inhibiting casein kinase Iε activity, comprising administering to said patient a therapeutically effective amount of a compound of formula I. its stereoisomer, enantiomer, racemate, ta... | 08/30/2011 |
| 7928138 | Marine actinomycete taxon for drug and fermentation product discovery The invention is the discovery of an actinomycete genus, given the name Salinospora gen. nov., that displays an obligate requirement of seawater (Na+) for growth and unique 16S rRNA signature nucleotides. The invention is also the use of the genus ... | 04/19/2011 |
| 7923466 | 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I Methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase Iε activity comprising the administration of a compounds of formula (I) and formula (II) as inhibitors ... | 04/12/2011 |
| 7910616 | Proteasome inhibitors Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to treating and/or ameliorating a disease or condition, such as cancer, a mic... | 03/22/2011 |
| 7737174 | Indole inhibitors of MDM2 and the uses thereof The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cel... | 06/15/2010 |
| 7732480 | Bicyclic compounds as modulators of androgen receptor function and method There are disclosed bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia... | 06/08/2010 |
| 7696241 | Bicyclic compounds as modulators of androgen receptor function and method The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for examp... | 04/13/2010 |
| 7691896 | Analogs of salinosporamide A Disclosed herein are analogs of Salinosporamide A, having the Formula I as follows: Like Salinosporamide A, the compounds of the present invention will inhibit the proteasome, an intracellular enzyme complex that destroys p... | 04/06/2010 |
| 7635712 | Salinosporamides and methods for use thereof The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonospora... | 12/22/2009 |
| 7579371 | Methods of using [3.2.0] heterocyclic compounds and analogs thereof Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a human or a rodent. ... | 08/25/2009 |
| 7514468 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein R1 to R6 and X are defined as in claim 1, the tautomers, enantiomers... | 04/07/2009 |
| 7442804 | Process for the preparation of furopyrroles The present invention relates to a process for the preparation of furopyrroles of general formula (I), comprising (a) heating a compound of the formula (II) under microwave irradiation optionally in the presence of an inert solvent, wherein A1 and A2... | 10/28/2008 |
| 7419975 | Organic compounds Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I ... | 09/02/2008 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7276530 | [3.2.0] Heterocyclic compounds and methods of using the same Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbia... | 10/02/2007 |
| 7265147 | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia, for the treatment of various diseases of the respiratory, urinary and... | 09/04/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7199081 | Aqueous compositions for seed treatment An aqueous composition suitable for applying fungicides to plant propagation materials is provided, comprising water and a blend of the following components, by weight: a) 2–10% of a surface-active agent comprising a1) at least one anionic surfactant;... | 04/03/2007 |
| 7179834 | Salinosporamides and methods for use thereof The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonospora... | 02/20/2007 |
| 7176233 | Salinosporamides and methods for use thereof The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonospora... | 02/13/2007 |
| 7176232 | Salinosporamides and methods for use thereof The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonospora... | 02/13/2007 |
| 7081464 | Topical compositions of cyclic amides as immunotherapeutic agents Novel amides and imides are inhibitors of tumor necrosis factorα and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. ... | 07/25/2006 |
| 6884754 | Aqueous compositions for seed treatment An aqueous composition suitable for applying fungicides to plant propagation materials is provided, comprising water and a blend of the following components, by weight: a) 2-10% of a surface-active agent comprising a1) at least one... | 04/26/2005 |
| 6864276 | Active substance combinations having insecticidal and acaricidal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G ... | 03/08/2005 |
| 6835719 | Pesticidal composition An environmentally safe pesticidal liquid suspension composition including a mixture of sulfur combined with pyrethrins and/or pyrethroids is provided. The pesticidal composition is effective to control plant diseases, as well as insect and mite pests. The compositi... | 12/28/2004 |
| 6780887 | Anti-ischemic compounds The present invention is related to a compound of formula (I), salts and pro-drugs of the compound (I) and methods for treating and/or preventing partial or total ischemia, methods for treating and/or preventing pathologies associated with ischemia or with mitochond... | 08/24/2004 |
| 6703379 | Benzene derivatives and pharmaceutical use thereof The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammat... | 03/09/2004 |
| 6677317 | Disaccharide derivatives for treating hyperglycaemia The invention relates to the use of the disaccharide derivatives 3'-aminosucrose, sucrose-C6-acid and palatinose-C6'-acid and/or of an amide or alkyl ester thereof for the prevention or treatment of hyperglycemias.... | 01/13/2004 |
| 6677310 | Ring-expanded nucleosides and nucleotides The present invention relates to compositions comprising analogues of purine nucleosides containing a ring-expanded ("fat") heterocyclic ring, in place of purine, and an unmodified or modified sugar residue, pharmaceutically acceptable derivatives of such... | 01/13/2004 |
| 6583144 | Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof. The compounds can inhibit the biosynthesis of triglycerides in the liver and can inhibit the secretion of lipoprotein containing apolipoprotein ... | 06/24/2003 |
| 6583170 | 2-Phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol and estrogen formulations The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treat... | 06/24/2003 |
| 6583171 | Antineoplastic agents Compounds, isolated from the bacteria Xenorhabdus bovienil, have antineoplastic activity. The invention provides pharmaceutical compositions containing the compounds and the methods for employing them as medicaments, particularly in the treatment of human... | 06/24/2003 |
| 6528513 | Pyrimidine derivatives Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.... | 03/04/2003 |
| 6518281 | Immunotherapeutic agents Novel amides and imides are inhibitors of tumor necrosis factor and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions.... | 02/11/2003 |
| 6492366 | Cyano-indole serotonin-reuptake inhibitor compound A compound selected from those of formula (I): ##STR1## wherein: R1 and R2 each independently represent hydrogen or, alkyl, T1 and T2 each independently represent alkylene, G represents a heterocyclic group selected of fo... | 12/10/2002 |
| 6458825 | Lactacystin analogs Compounds related to lactacystin and lactacystin lactone, pharmaceutical compositions containing the compounds, and methods of use.... | 10/01/2002 |
| 6451841 | Method of diffusing an acaricidal composition comprising permethrin and tetramethrin, and the use of a catalytic combustion flask for implementing such a method The invention relates to a method of combating insects and parasites, and in particular acarids, the method comprising a step of diffusing a composition that includes permethrin in a solvent. The method is such that a composition is diffused in a chamber ... | 09/17/2002 |
| 6441019 | Cyclocarbamate and cyclic amide derivatives This invention provides compounds of the formula: ##STR1## wherein A and B are independent substituents selected from S, CH or N; provided that when A is S, B is CH or N; and when B is S, A is CH or N; and A and B cannot both be CH; and when A and B both ... | 08/27/2002 |
| 6395764 | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agnonists This invention involves compounds having the following structure: ##STR1## wherein: a) R1 is hydrogen; or alkyl; bond (a) is a single or a double bond; b) R2 and R3 are each independently selected from hydrogen; unsubstituted C... | 05/28/2002 |
| 6365608 | Fungicide mixtures based on pyridine carboxamides Fungicidal mixtures comprise as active components a) an amide compound of the formula I A--CO--NR1 R2 I in which A is an aryl group or an aromatic or non-aromatic, 5- or 6-membered heterocycle which has from 1 to 3 hetero atoms selected from... | 04/02/2002 |
