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| Number | Title | Issue Date |
| 7943586 | Antineoplastic agents targeted via glut transporters The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which... | 05/17/2011 |
| 7811999 | Use of lipid conjugates in the treatment of diseases This invention provides a method of treating a subject suffering from an obstructive respiratory disease, including the step of administering to a subject a compound comprising a lipid or phospholipid moiety bound to a physiologically acceptable monomer, dimer, olig... | 10/12/2010 |
| 7772196 | Use of lipid conjugates in the treatment of diseases This invention provides a method of treating a subject suffering from a dermatologic condition, including, inter alia, psoriasis, contact dermatitis, and seboreic dermatitis, the method includes the step of administering to a subject a compound comprising a lipid or... | 08/10/2010 |
| 7745415 | 3-β-D-ribofuranosylthiazolo[4,5-]pyrimidine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compou... | 06/29/2010 |
| 7687473 | 5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism The present invention provides a method for increasing the efficacy of antifolates which act via inhibition of dihydrofolate reductase (DHFR). The method comprises the steps of administration of 5-amino-4-imidazolecarboxamide riboside (Z) or its base with the antifo... | 03/30/2010 |
| 7608598 | Use of lipid conjugates in the treatment of conjunctivitis In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound via an ester or amide bond to a physi... | 10/27/2009 |
| 7608597 | Methods and compositions for treating hepatitis C virus A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.... | 10/27/2009 |
| 7553820 | Mevalonic acid derivatives This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 ha... | 06/30/2009 |
| 7521430 | N-glucoside compounds having an inhibitory activity against sodium-dependent glucose transporter A compound of the formula: wherein Ring A and Ring B are (1) Ring A is an optionally substituted unsaturated monocyclic heterocyclic ring, and Ring B is an optionally substituted unsaturated monocyclic heterocyclic ring, an... | 04/21/2009 |
| 7504384 | Use of lipid conjugates in the treatment of infection This invention provides compounds and methods of use thereof in suppressing, inhibiting, preventing, or treating a pathogenic effect on a cell, including, inter alia, infection with intracellular pathogens. Also provided are compounds and methods of use thereof in s... | 03/17/2009 |
| 7432272 | Antiviral analogs The application relates to 4′-substituted nucleoside derivatives of Formula I: wherein B and R1 have any of the values described in the application, as well as to compositions comprising such compounds, to meth... | 10/07/2008 |
| 7429569 | Compositions and methods for the regulation of homocysteine levels within the body Described herein is a method for reducing levels of the harmful metabolic waste product of S-adenosylmethionine (SAMe), homocysteine, and provide vitamin and other nutritional co-factors that reduce the production of homocysteine and either re-methylate homocysteine... | 09/30/2008 |
| 7414072 | Aryl 5-thio-β-d-glucopyranoside derivatives and therapeutic agents for diabetes containing the same There is provided a 5-thio-β-D-glucopyranoside compound of the following formula, which has an inhibitory effect on SGLT2 activity, or a pharmaceutically acceptable salt thereof or a hydrate thereof. There is also provided a pharmaceutical preparation, particularly... | 08/19/2008 |
| 7405204 | Nucleoside compounds for treating viral infections Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus. ... | 07/29/2008 |
| 7405214 | Nucleoside derivatives and therapeutic use thereof The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disord... | 07/29/2008 |
| 7402569 | Treatment of with isothiocyanates The present invention relates to methods of preventing or inhibiting the growth of Helicobacter through the use of a composition that comprises a glucosinolate, an isothiocyanate or a derivative or metabolite thereof. The present invention also relates to met... | 07/22/2008 |
| 7393839 | Polymorphic antiviral nucleoside compounds The present invention relates to the polymorphic crystalline hydrochloride salts of a nucleoside valinate ester according to formula Ib, methods of treating diseases mediated by Hepatitis C Virus and pharmaceutical composition containing Ib | 07/01/2008 |
| 7390785 | τ-conotoxin peptides The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably i... | 06/24/2008 |
| 7390782 | Methods and products related to metabolic interactions in disease The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.... | 06/24/2008 |
| 7365057 | Modified 2′ and 3′-nucleoside prodrugs for treating infections 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and o... | 04/29/2008 |
| 7323594 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/29/2008 |
| 7319093 | Antidiabetic 2-substituted-5′-O-(1-Boranotriphosphate) adenosine derivatives 2-Substituted-5′-O-(1-boranotriphosphate)adenosine derivatives having at position 2 a radical R1 selected from the group consisting of H; halogen; O-hydrocarbyl; S-hydrocarbyl; NR3R4; and hydrocarbyl optionally substituted by halogen, CN, SCN, NO2, OR3, SR3 or NR3... | 01/15/2008 |
| 7303792 | Diaminobenzene derivative, polyimide precursor and polyimide obtained therefrom, and aligning agent for liquid crystal The present invention provides a novel diamine which is especially useful as a material for a resin for a liquid crystal alignment film, a polyimide precursor and a polyimide synthesized by using the diamine, and a treating agent for liquid crystal alignment contain... | 12/04/2007 |
| 7297689 | Method for preparing peritoneal dialysate Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated during sterilization and storage of the peritoneal dialysate can be e... | 11/20/2007 |
| 7288528 | Aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted aromatic fluoroglycoside derivatives of the formula I in which ... | 10/30/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7279465 | Use of amphiphilic nucleoside phosphonoformic acid derivatives for the treatment of viral infectious diseases The invention relates to a method for treating infectious diseases which are elicited by viruses which are pathogenic to humans comprising the step of administering an amphiphilic nucleoside-phosphonoformic acid derivative having an esterified or unesterified carbox... | 10/09/2007 |
| 7265098 | Polyacid/polyalkylene oxide gels and methods for their delivery The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylen... | 09/04/2007 |
| 7256179 | Nucleic acid-based compounds and methods of use thereof The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units. ... | 08/14/2007 |
| 7247745 | Process for preparing 1,5-diaryl-3-substituted pyrazoles A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III | 07/24/2007 |
| 7244716 | Pharmaceutical composition of antiviral agents In accordance with the present invention there is provided a pharmaceutical composition useful for the treatment or prophylaxis of viral infections comprising tipranavir and at least one antiviral active compound of formula (I) | 07/17/2007 |
| 7223845 | Synthetic glycosulfopeptides and methods of synthesis thereof A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewisx group or a sialyl Lewisa group. In a preferred version the ... | 05/29/2007 |
| 7217730 | Method for the use of pyranoindole derivatives to treat infection with Hepatitis C virus The invention is directed to methods of treating, preventing, or inhibiting a Hepatitis C viral infection in a mammal comprising contacting the mammal with an effective amount of a compound of the formula: Wherei... | 05/15/2007 |
| 7192936 | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and o... | 03/20/2007 |
| 7189828 | Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and sialyated, fucosylated N-acetyllactosamino glycans. The glycosulfopepti... | 03/13/2007 |
| 7189874 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S... | 03/13/2007 |
| 7179905 | Nucleic acid labeling compounds Nucleic acid labeling compounds containing heterocyclic derivatives are disclosed. The heterocyclic derivative containing compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds a... | 02/20/2007 |
| 7179487 | Hydrogels of water soluble polymers crosslinked by protein domains A stimuli-responsive, hybrid hydrogel wherein the bulk of the polymer is made up of relatively inexpensive water soluble polymer strands crosslinked by protein domains. The responsiveness of the gel is controlled or modulated by the protein component. The phy... | 02/20/2007 |
| 7176296 | Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides The invention provides compounds having increased or reduced immunostimulatory effect, said compounds comprising a CpG dinucleotide and an immunomodulatory moiety wherein the increased or reduced immunomodulatory effect is relative to a similar compound lacking the ... | 02/13/2007 |
| 7173154 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 02/06/2007 |
