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| Number | Title | Issue Date |
| 8138220 | [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine and pharmaceutically acceptable salts thereof, provided it is not the free base in a non-crystalline form are provided for the treatment of affective disorders. ... | 03/20/2012 |
| 8124647 | Non-steroidal androgens compounds This invention provides non-steroidal compounds with affinity for the androgen receptor and utility for androgen-receptor related treatments, having a structure according to the formula or a salt or hydrate form thereof. | 02/28/2012 |
| 8088816 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl) -3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative... | 01/03/2012 |
| 8084487 | Processes for the preparation of 4-oxo-octahydro-indole-1-carbocyclic acid methyl ester and derivatives thereof The present invention relates to a process for the production of carbamic acid (2-chloroethyl)(3-oxocyclohexyl)-alkyl ester enantiomers and of 1-carbalkoxy-4-ketoperhydroindole enantiomers. ... | 12/27/2011 |
| 8044090 | N-(2-arylethyl)benzylamines as antagonists of the 5-HT6 receptor The present invention provides compounds of formula (I), which are antagonists of the 5-HT6 receptor. ... | 10/25/2011 |
| 7846962 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative,... | 12/07/2010 |
| 7825155 | Oxindole derivative as feeding control agent Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent for diabetes and the like. ... | 11/02/2010 |
| 7803834 | Substituted oxindole derivatives, drugs containing said derivatives and the use thereof The invention relates to novel oxindol derivative of general formula (I), wherein substituents R1, R2, A, B and Y are such as defined in a claim 1. Drugs containing said derivatives and the use thereof for preventing and/or treating vass... | 09/28/2010 |
| 7776907 | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodru... | 08/17/2010 |
| 7741362 | Somatostatin receptor 1 and/or 4 selective agonists and antagonists The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and sele... | 06/22/2010 |
| 7737172 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative,... | 06/15/2010 |
| 7718690 | N-arylsulfonyl-3-aminoalkoxyindoles N-arylsulfonyl-3-aminoalkoxyindoles indole compounds, radioisotopes, stereoisomers, geometric forms, N-oxides, polymorphs and pharmaceutically acceptable salts. ... | 05/18/2010 |
| 7691895 | Thrombopoietin activity modulating compounds and methods Disclosed herein are compounds of Formula (I), (II), and (III) pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds a... | 04/06/2010 |
| 7687535 | Substituted 3-sulfur indoles The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders. ... | 03/30/2010 |
| 7632856 | Indolone derivatives, processes for preparing them and their uses The present invention relates to indolone derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals. ... | 12/15/2009 |
| 7595338 | Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing 5-pyrrole-3,3-oxindole compounds and 5-(7-fluoro-3,3-dimethyl-2-oxo-... | 09/29/2009 |
| 7595339 | CB1 modulator compounds Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention ... | 09/29/2009 |
| 7560480 | Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments The present invention relates to alkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and t... | 07/14/2009 |
| 7504428 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives The present invention a method of treating anxiety by administering compounds that are active on the GABAB receptor, having formula I: wherein R1, R2, R3, R4, R5 | 03/17/2009 |
| 7465750 | Use of GAL3 antagonist for treatment of depression and/or anxiety and compounds useful in such methods This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceut... | 12/16/2008 |
| 7414054 | 3-(arylamino)methylene-1, 3-dihydro-2H-indol-2-ones as kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 08/19/2008 |
| 7410994 | Indole derivatives as anti-inflammatory agents This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH2—, —O—, —S—, or —S(O)—; and the other... | 08/12/2008 |
| 7399780 | 3-Heterocyclyl-indole inhibitors of glycogen synthase kinase-3 The present invention provides new compounds of formula Ia and Ib: as well as a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in ... | 07/15/2008 |
| 7396852 | Compound having indolocarbazole moiety and divalent linkage A compound including at least one type of an optionally substituted indolocarbazole moiety and at least one divalent linkage. ... | 07/08/2008 |
| 7396853 | 2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification and claims, which compounds ar... | 07/08/2008 |
| 7378439 | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride The present invention discloses a novel process and novel intermediates for the Preparation of 4-[2-(di-n-propyl amino) ethyl]-1,3-dihydro-2H-indol-2-one, commonly known as Ropinirole (I) and pharmaceutical composition comprising the same. Further the present invent... | 05/27/2008 |
| 7345084 | Indole derivatives useful as progesterone receptor modulators The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of ... | 03/18/2008 |
| 7342040 | 5-fluorooxindole-3-carboxylic acid ester A 5-fluorooxindole-3-carboxylic acid ester represented by a formula (2): wherein R1 is a group selected from the group consisting of an unsubstituted or substituted alkyl group having 1 t... | 03/11/2008 |
| 7338966 | Substituted oxindole derivatives as tyrosine kinase inhibitors The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alt... | 03/04/2008 |
| 7335649 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 02/26/2008 |
| 7332481 | Thrombopoietin mimetics Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comp... | 02/19/2008 |
| 7332516 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is â€... | 02/19/2008 |
| 7319100 | Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands Compounds provided herein are novel substituted pyrazinones, pyridines and pyrimidines of Formula (I) and (II): Such compounds are particularly useful as CRF receptor ligands, and hence, in the treatment of vario... | 01/15/2008 |
| 7314887 | Thrombopoietin activity modulating compounds and methods Disclosed herein are compounds of Formula (I), (II), and (III) pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying ... | 01/01/2008 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7309715 | Compound A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl... | 12/18/2007 |
| 7307099 | 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents This invention pertains to certain 4-(1-(sulfonyl)-1H-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds, and analogs thereof, including compounds of the following formula, which are, inter alia, antiproliferative agents, anticancer agents, and/or thioredoxin/t... | 12/11/2007 |
| 7288251 | Antibodies to CD40 The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof.... | 10/30/2007 |
| 7288526 | Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 10/30/2007 |
| 7276516 | CB1 antagonist compounds Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention ... | 10/02/2007 |
