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A method of swing on a swing is disclosed, in which a user positioned on a standard swing suspended by two chains from a substantially horizontal tree branch induces side to side motion by pulling alternately on one chain and then the other.
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| Number | Title | Issue Date |
| 8173693 | Benzenesulfonamide derivatives and pharmaceutical composition thereof The present invention is related to derivatives of benzenesulfonamide represented by formula (I), and the pharmaceutical composition thereof. In addition, the benzenesulfonamide derivatives disclosed in the present invention can serve as potential cell cycle inhibit... | 05/08/2012 |
| 8168673 | Compounds having CRTH2 antagonist activity Compounds of general formula (I) wherein W is chloro or fluoro; Z is a group SO2R1; wherein R1 is —C3... | 05/01/2012 |
| 8153680 | Alkyl indole-3-carbinol-derived antitumor agents Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; ... | 04/10/2012 |
| 8138218 | Growth hormone secretagogues A family of peptides and peptidomimetic compounds useful as GHS analogs according to either formula (I) or (II) as depicted below: or a pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification. | 03/20/2012 |
| 8138219 | Tryptamine sulfonamides as 5-HTantagonists Novel compounds of the structural formula (I) are antagonists of the 5-HT6 receptor and are useful in the treatment, prevention and suppression of diseases mediated by the 5-HT6 receptor. The compounds of the present invention are useful in the... | 03/20/2012 |
| 8129424 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their sa... | 03/06/2012 |
| 8124645 | LPA receptor antagonist A compound of the general formula (I): (wherein the symbols are as defined in the description), or a non-toxic salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is useful in the prevention... | 02/28/2012 |
| 8119683 | Aryl substituted sulfonamide compounds and their use as anticancer agents Aryl substituted sulfonamide compounds of formula (I): wherein bond, X, Y, R1, R2, R3, m, and n are defined herein. Also disclosed is a method for treating cancer with these compounds. ... | 02/21/2012 |
| 8097644 | Indole compounds having sphingosine-1-phosphate (S1P) receptor antagonist The present invention provides novel compounds having the following general formula I wherein: A, B, X, Y, R1, R2, R3, R4, n, o and p are as defined in the specification. Such com... | 01/17/2012 |
| 8097645 | Compounds for activating TGF-β signaling Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-β signaling are described. ... | 01/17/2012 |
| 8097643 | Indol-4 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators The present invention refers to new sulfonamide derivatives, of general formula (1a, 1b, 1c), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of t... | 01/17/2012 |
| 8093286 | Methods for treatment with bucindolol based on genetic targeting The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is h... | 01/10/2012 |
| 8080578 | Methods for treatment with bucindolol based on genetic targeting The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is h... | 12/20/2011 |
| 8080577 | Diindolylmethane formulations for the treatment of leiomyomas The present invention relates to compositions and methods for treating or preventing leiomyomas by administration of diindolylmethane and diindolylmethane-related indoles. The present invention also relates to compositions and methods for treating or preventing leio... | 12/20/2011 |
| 8053462 | Indole derivative and application thereof This invention relates to a compound represented by formula (I) or a salt thereof, and a therapeutic agent for osteoporosis, an osteoblast activator, and an osteoclast suppressor comprising the same: wherein X represents a ... | 11/08/2011 |
| 8053463 | PPAR active compounds Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ, wherein the compounds have the formula: | 11/08/2011 |
| 8022095 | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs The invention is directed to methods and compositions that can be used in the treatment of headaches. In particular, methods and compositions are described involving the combination of a long-acting NSAID and a 5-HT1B/1D agonist. ... | 09/20/2011 |
| 8017644 | 2-arylindole derivatives as nPGES-1 inhibitors A 2-arylindole compound substituted in position 5, of formula (I): in which X, Y, Z, W, A, R and R′ have the meanings given in the description, a pharmaceutical composition comprising it, and also intermediate compounds and a preparation process therefor. | 09/13/2011 |
| 8013006 | Methods for treating hepatitis C In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevent... | 09/06/2011 |
| 8013007 | Alpha 1A-adrenoceptor antagonists This invention relates to novel compounds that are dihydroindoles derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel dihydroindoles derivatives that are derivatives of silodosin. This invention also provides... | 09/06/2011 |
| 7989486 | Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions The present invention includes compositions and methods for the treatment and prevention of conditions associated with Respiratory Syncytial Virus (RSV) infection. RSV-associated conditions include acute infections in mammals, typically bronchiolitis and pneumonia, ... | 08/02/2011 |
| 7977370 | (Hetero)aryl cyclohexane derivatives The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions. ... | 07/12/2011 |
| 7973069 | Methods for treating hepatitis C The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity. ... | 07/05/2011 |
| 7968589 | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included. ... | 06/28/2011 |
| 7964627 | Amino arylsulfonamide compounds and their use as 5-HTligands The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relate... | 06/21/2011 |
| 7956083 | Compounds The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases. ... | 06/07/2011 |
| 7932284 | Indole sulfonamide modulators of progesterone receptors Compounds of Formula (I), wherein n is 1 or 2, and R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, their preparation, pharmaceutical compositions, and methods of use are disclosed. ... | 04/26/2011 |
| 7906548 | Methods for the use of inhibitors of cytosolic phospholipase A2 This invention provides methods for the use of substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof. The invention provides methods for the use of the compounds as inhibito... | 03/15/2011 |
| 7902249 | Indole derivatives substituted with long-chain alcohols and medicaments containing them Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each inde... | 03/08/2011 |
| 7872040 | Receptor blocker and vasodilator comprising indole derivative as active ingredient It is intended to find a compound that is structurally simpler than yohimbine, a pentacyclic condensed heterocyclic compound, and has an effect similar to that of yohimbine. The present invention relates to a pharmaceutical or food composition for α2 | 01/18/2011 |
| 7868037 | Methods for treating hepatitis C The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity. ... | 01/11/2011 |
| 7868036 | Organic compounds The invention relates to novel amino alcohols of the general formula (I) where X, R1, R2, R3, R4, R5 and R6 are each as defined in detail in the description, to a process for their preparation and to ... | 01/11/2011 |
| 7858656 | Controlled release formulations containing an active ingredient, preferably melatonin and the method of preparation A controlled release melatonin tablet having a slow release nucleus of melatonin, hydroxypropyl methylcellulose, a lubricant, a volume excipient and a glidant, wherein 95% of the melatonin is released within 5 hours in an oscillating tray containing gastric/intestin... | 12/28/2010 |
| 7855224 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders This invention relates to compounds having pharmacological activity, to compositions containing these compounds, and to a method of treatment employing the compounds and compositions. More particularly, this invention concerns certain indole derivatives and their sa... | 12/21/2010 |
| 7834049 | Integrin expression inhibitor The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of... | 11/16/2010 |
| 7834050 | Small molecule insulin mimetics absent quinones Compounds of Formula I are described along with pharmaceutical formulations thereof, and methods of treating disorders such as diabetes and neurodegenerative diseases with such compounds. ... | 11/16/2010 |
| 7807705 | Potent indole-3-carbinol-derived antitumor agents Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I: wherein X is hydroxyl or amino; Y is carboxyl or sulfonyl; R1, R | 10/05/2010 |
| 7799820 | 2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable salt thereof. In the formula,... | 09/21/2010 |
| 7795295 | Small molecule inhibition of PDZ-domain interaction Novel compounds that have been found effective in inhibiting PDZ domain interactions, and particularly interactions of PDZ domains in MAGIs with the oncogenic (tumor suppressor) protein PTEN and interactions between the PDZ domain in the Dishevelled (Dvl) protein an... | 09/14/2010 |
| 7781479 | Heteroaryl derivatives A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. whe... | 08/24/2010 |
