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| Number | Title | Issue Date |
| 8106087 | Spiro-oxindole compounds and their uses as therapeutic agents This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R | 01/31/2012 |
| 8088815 | Spiroindolinone pyrrolidines There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as ... | 01/03/2012 |
| 8044085 | Active agent combinations with insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula ... | 10/25/2011 |
| 8039503 | Lapachone compounds and methods of use thereof The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphtho... | 10/18/2011 |
| 7968585 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 The present invention discloses novel compounds of Formula (I): having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I,... | 06/28/2011 |
| 7935721 | Spiro-oxindole compounds and their uses as therapeutic agents This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R | 05/03/2011 |
| 7825152 | Organic compounds and their uses The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. ... | 11/02/2010 |
| 7803833 | Compounds The invention relates to quaternary α-aminocarboxyamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, X, q and n are as defined in claim 1, for treating diseases and conditions m... | 09/28/2010 |
| 7759383 | Small molecule inhibitors of MDM2 and the uses thereof The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cel... | 07/20/2010 |
| 7723372 | Spiroindolinone derivatives There are provided compounds of the general formulas wherein W, X, Y, R1, R2, R3, and R4 are as described herein. The compounds exhibit anticancer activity. ... | 05/25/2010 |
| 7700641 | Spiro-oxindole compounds and their uses as therapeutic agents This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R | 04/20/2010 |
| 7659300 | Monocyclic anilide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treat... | 02/09/2010 |
| 7655686 | Certain substituted spirocyclic lactams and use thereof as pharmaceuticals The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4.4]non-7-yl)-propionamides of the formula wherein R1, R2, R3, R4, R5, R6, m and p are as def... | 02/02/2010 |
| 7638548 | Spiroindolinone derivatives There are provided compounds of the general formulas wherein X, Y, R1, R2, R3 and R4 are as described herein. The compounds exhibit anticancer activity. ... | 12/29/2009 |
| 7638547 | Cis-alkoxy-substituted spirocyclic 1H-pyrrolidine-2,4-dione derivatives serving as pesticides The invention relates to novel cis-alkoxy-substituted spirocyclic 1H-pyrrolidine-2,4-dione derivatives of the formula (I) in which A, G, X and Y are as defined in the disclosure, to a plurality of p... | 12/29/2009 |
| 7550499 | Urea antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of ... | 06/23/2009 |
| 7514466 | Purification of progesterone receptor modulators Methods for purifying a compound of formula I are provided, wherein A, B X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precip... | 04/07/2009 |
| 7476688 | Cyclic amidine derivatives A cyclic amidine derivative represented by the formula: [wherein R1, R2 and R3 represent hydrogen, C1-6 alkyl, aryl-C1-6 alkyl, etc.; R4, R5 and R... | 01/13/2009 |
| 7439263 | Pyrrolidine and thiazolidine compounds Compounds of formula (I): wherein: X1 represents an atom or group selected from CR4aR4b, O, S(O)q1 and NR5, wherein R4a, R... | 10/21/2008 |
| 7410978 | Once daily dosage forms of trospium A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum (Cmin) and maximum (Cmax) blood levels of about 0... | 08/12/2008 |
| 7396846 | Growth hormone secretagogues This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in thes... | 07/08/2008 |
| 7393858 | Tetrahydropyran compounds as tachykinin antagonists The present invention relates to compounds of formula (Ia) wherein A, B, n, m, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 ... | 07/01/2008 |
| 7390798 | Carboxamide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in... | 06/24/2008 |
| 7371865 | Process for the manufacture of HMG-CoA reductase inhibitors The invention relates to a process for the manufacture of a compound of formula or a salt, especially a pharmaceutically acceptable salt with a base, thereof or a lactone thereof wherein the element represents —CH2 | 05/13/2008 |
| 7332519 | Spirocyclic cyclohexane compounds Spirocyclic cyclohexane compounds, methods for their production, pharmaceutical compositions containing these compounds, and the use of these spirocyclic cyclohexane compounds for treating conditions associated with the nociceptin/ORL1 receptor system, e.g. pain, dr... | 02/19/2008 |
| 7323455 | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3)-one derivatives and their use as progesterone receptor modulators This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof. ... | 01/29/2008 |
| 7309787 | Kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 12/18/2007 |
| 7304081 | Amido compounds and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases... | 12/04/2007 |
| 7288560 | Spirocyclic cyclohexane derivatives The present invention relates to spirocyclic cyclohexane compounds, to methods for their production, to pharmaceutical compositions containing these compounds, to methods of treatment using such compounds and to the use of such spirocyclic cyclohexarie compounds for... | 10/30/2007 |
| 7250438 | Anti-bacterial and anti-cancer spiro beta-lactone/gamma-lactams Disclosed herein are novel spiro beta-lactone/gamma lactams for use in treating bacterial infections and cancer. The compounds are characterized by a terminal electron-withdrawing group such as a nitro group. Screening data shows antimicrobial activity against vario... | 07/31/2007 |
| 7238703 | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT, and neuronal nicotinic receptor antagonists Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexanes which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of tr... | 07/03/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7205324 | Inhibitors of IMPDH enzyme The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as tr... | 04/17/2007 |
| 7205417 | Spiro compounds Compounds of the formula (I): (wherein A is an optionally substituted straight-chain hydrocarbon having 1 to 6 carbon atoms, which is optionally intervened by oxygen or nitrogen... | 04/17/2007 |
| 7205407 | 3-Substituted oxindole β3 agonists The present invention relates to a β3 adrenergic receptor agonist of Formula (I) or a pharmaceutical salt thereof; useful for treating Type II diabetes and/or obesity ... | 04/17/2007 |
| 7205328 | Oxindoles with anti-HIV activity The present invention relates to inhibition of viruses, e.g., HIV using oxindoles and compounds related to oxindoles. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell... | 04/17/2007 |
| 7163922 | Tripeptide derivatives for the treatment of postlesional diseases of the nervous system The invention relates to the use of specific tripeptides for the treatment of postlesional diseases of ischemic, traumatic or toxic origin. The tripeptide derivatives satisfy formula (I), wherein X represents OH, (C1-5)alkoxy, NH2, NH—C1... | 01/16/2007 |
| 7138529 | Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the... | 11/21/2006 |
| 7115575 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof The present invention relates to glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 represents a hydrogen atom or a lower alkyl group; one of Q1 and T1... | 10/03/2006 |
| 7091233 | Active substance combinations comprising insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties. ... | 08/15/2006 |
