Did You Know...
...During the Civil War, the Confederacy established its own Patent Office which issued 266 patents, a third of which concerned implements of war.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8101644 | Pyrrolinone derivative and pharmaceutical composition comprising the same The present invention provides a compound represented by the formula (I): wherein R1, R2, R3, Z1, Z2, Ra, Rb, q, A and n are as defined in the des... | 01/24/2012 |
| 8084485 | 6-(aminoalkyl)indazoles 6-(Aminoalkyl)indazoles of formula (I) and the salts thereof have renin-inhibiting properties and can be used as antihypertensive, and renal, cardiac and vascular protecting medicinally active ingredients. ... | 12/27/2011 |
| 8063091 | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using th... | 11/22/2011 |
| 8053459 | Selenolopyrazole derivatives and use thereof as anticancer agents The present invention synthesizes a series of selenolo[3,2-c]pyrazole and selenolo[2,3-c]pyrazole derivatives, and discovers their anticancer activity. ... | 11/08/2011 |
| 7968583 | Substituted pyrrolo-pyrazole derivatives active as kinase inhibitors Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be... | 06/28/2011 |
| 7846959 | Raf modulators and methods of use The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell... | 12/07/2010 |
| 7842712 | Indazolinone compositions useful as kinase inhibitors The present invention provides compounds of formula I: These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK... | 11/30/2010 |
| 7820707 | Heterocyclic derivatives The present invention relates to a heterocyclic derivative according to formula I wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention... | 10/26/2010 |
| 7816390 | N-substituted tricyclic 3-aminopyrazoles as anti-mitotic tubulin polymerization inhibitors The invention is directed to compounds having the following structures: N-(3-ethoxyphenyl)-1,4-dihydro-6-ethoxy-7-(3-hydroxypropoxy)-1-methylindeno[1,2-c]pyrazole-3-amine; 3-[3-(3... | 10/19/2010 |
| 7803830 | 3-amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb... | 09/28/2010 |
| 7772268 | Diacyl indazole derivatives as lipase and phospholipase inhibitors The invention relates to diacyl indazole derivatives of general formulae (I) or (II) and to the pharmaceutically acceptable salts thereof: Wherein X, R1 and R2 are as defined herein. The invention also relates to the use of t... | 08/10/2010 |
| 7767705 | Compounds that inhibit TRPV1 and uses thereof Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compo... | 08/03/2010 |
| 7625937 | 1H-benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators The present invention encompasses compounds of Formula I: or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and infl... | 12/01/2009 |
| 7622492 | Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 11/24/2009 |
| 7612106 | Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. | 11/03/2009 |
| 7582669 | Aminoindazole derivatives as medicaments and pharmaceutical compositions including them The present invention relates to novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl fused to a (1-10C) cycloalkyl... | 09/01/2009 |
| 7541376 | 1H-indazole compounds The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Whe... | 06/02/2009 |
| 7517901 | p38 MAP kinase inhibitors and methods for using the same Compounds of formula Ia or Ib: wherein X and Y are nitrogen or CRe, and R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the... | 04/14/2009 |
| 7514463 | Lonidamine analogues and their use in male contraception and cancer treatment Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha. ... | 04/07/2009 |
| 7473701 | Substituted indazoles, compositions containing them, method of production and use Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting activity, having therapeutic activity, in particular in oncology. ... | 01/06/2009 |
| 7449488 | Pyrazolopyrimidines as protein kinase inhibitors In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, me... | 11/11/2008 |
| 7425572 | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma Novel dioxinoindazole compounds and dioxoloindazole compounds are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions of one or more of... | 09/16/2008 |
| 7407950 | -(heteroaryl)-1-indole-2-carboxamide derivatives and their use as vanilloid TRPV1 receptor ligands The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Z1, Z2, Z3, Z4, Z5 and W are as defined herein. | 08/05/2008 |
| 7390797 | Fused indazole compounds The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. ... | 06/24/2008 |
| 7354928 | Small molecule inhibitors targeted at Bcl-2 The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-XL. In particular, the present invention provides non-peptide cell permeable small molecules (e.g., tricyclo-dibenzo-diazocine-dioxides) that bin... | 04/08/2008 |
| 7354944 | Thiadiazole compounds and methods of use The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnorm... | 04/08/2008 |
| 7342046 | Gossypol co-crystals and the use thereof This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (... | 03/11/2008 |
| 7338972 | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma Substituted 1-alkylamino-1H-indazoles for lowering intraocular pressure and treating glaucoma are disclosed. ... | 03/04/2008 |
| 7312239 | Medicament for prevention and/or therapy of arterial wall disorder An object of the present invention is to provide a medicament and method which is useful for prevention and/or therapy of arterial wall injury. According to the present invention, there is provided a method for prevention and/or therapy of arterial wall injury which... | 12/25/2007 |
| 7300950 | Pyrazole derivatives, their preparation and their use in pharmaceuticals The present invention relates to pyrazole derivatives of the formula I, their preparation and their use in pharmaceuticals: in which X, R1, R1a, R2, R3, R4 a... | 11/27/2007 |
| 7291612 | Immunomodulatory compounds The present invention relates to novel heterocyclic compounds, to methods for their preparation, to compositions containing them, and to methods and use for clinical treatment of medical conditions which may benefit from immunomodulation, including rheumatoid arthri... | 11/06/2007 |
| 7285553 | Serotonergic 5HTreceptor compounds for treating ocular and CNS disorders Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for... | 10/23/2007 |
| 7262200 | Indazolinone compositions useful as kinase inhibitors The present invention provides compounds of formula I: These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK... | 08/28/2007 |
| 7259183 | Indole, indazole and indoline derivatives as CETP inhibitors The present invention relates to compounds of formula (I): wherein —X—Y—, R1 to R11 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. T... | 08/21/2007 |
| 7241792 | Fused pyrazole derivatives and methods of treatment of metabolic-related disorders thereof The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. | 07/10/2007 |
| 7226941 | Compound for treating angiogenesis The present invention provides methods and pharmaceutical compositions for inhibiting expressions of HIF and HIF regulated genes, inhibiting angiogenesis, inducing cell cycle arrest in tumor cells, and treating cell proliferating diseases or conditions. ... | 06/05/2007 |
| 7214699 | Indazole derivatives as CRF antagonists This invention relates to compounds which are generally CRF-1 receptor antagonists and which are represented by Formula I or Formula II: wherein R3 is optionally substituted aryl or heteroaryl, R1... | 05/08/2007 |
| 7211597 | Substituted pyrazolyl compounds for the treatment of inflammation The present invention relates to compounds of Formula I: wherein A is (CH2)m-Q-(CH2)n, wherein each CH2 may be independently substituted with one or more substitut... | 05/01/2007 |
| 7208512 | Benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma The present invention provides benzodifuran imidazoline derivatives and benzofuran imidazoline derivatives for lowering intraocular pressure and providing ocular neuroprotection. ... | 04/24/2007 |
| 7199147 | Rho kinase inhibitors A compound represented by the formula (1): wherein R1—X— indicates that 1 to 4 R1—X— groups are present which may be the same or different, the rin... | 04/03/2007 |
