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Safety System For Remove a Rider From a Vehicle by Deploying a Parachute
Methods and apparatus for reducing the velocity of a rider in or on an open cockpit vehicle when the rider is thrown from the vehicle.
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| Number | Title | Issue Date |
| 8178572 | Amino acid compounds A method for increasing the vasodilative characteristics of amino acids in a human or animal is disclosed. The method includes administering to the human or animal a pharmaceutically effective amount of an amino acid compound consisting essentially of a nitrate or n... | 05/15/2012 |
| 8168669 | Therapeutic agent for inflammatory bowel disease and TNF-α production inhibitor Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid sele... | 05/01/2012 |
| 8163791 | Imidazole derivatives that induce apoptosis and their therapeutic uses The present invention relates to a pharmaceutical composition comprising compound for induction of apoptosis, a method for inducing cancer cell apoptosis, a method to suppress lymphocyte activation, a method to improve intracellular trafficking of misfolded mutants ... | 04/24/2012 |
| 8067381 | Methods and compositions for increasing the anaerobic working capacity in tissues Provided are compositions comprising beta-alanylhistidine peptides and/or beta-alanines, and methods for administering these peptides and amino acids. In one aspect, the compositions and methods cause an increase in the blood plasma concentrations of beta-alanine an... | 11/29/2011 |
| 8034836 | Amino acid compounds An Amino Acid Compound is described. The Amino Acid Compound may comprise an Amino Acid and one of a Nitrate and a Nitrite. The Amino Acid may be one of Aspartic Acid, Cysteine, Glycine, Lysine, Methionine, Proline, Tyrosine, and Phenylalanine. ... | 10/11/2011 |
| 8030339 | Imidazole derivatives for the treatment of anxiety and related diseases This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, whi... | 10/04/2011 |
| 8026268 | Method for scavenging radicals with urocanic acid, derivatives and analogues The invention relates to antioxidants or radical scavengers and their reaction products. The invention provides compounds and compositions for use in methods for scavenging radicals or for modulating the immune response comprising urocanic acid or salts, derivatives... | 09/27/2011 |
| 8017642 | Functionally selective ALPHA2C adrenoreceptor agonists In its many embodiments, the present invention provides a novel class of naphthene- and indane-type as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of... | 09/13/2011 |
| 7994206 | Crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimet... | 08/09/2011 |
| 7973068 | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that exhibits alpha-adrenergic activity and one or more additional pain and inflammat... | 07/05/2011 |
| 7960350 | Composition and method for the treatment of eye disease Embodiments of the invention disclosed herein relate to methods of preventing and/or ameliorating one or more symptoms associated with an eye disease such as dry eye syndrome, cataracts of the eye and nuclear sclerosis of the eye lens by administering to a subject a... | 06/14/2011 |
| 7939556 | Imidazole derivatives and their use for modulating the GABAreceptor complex This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, whi... | 05/10/2011 |
| 7932282 | Imidazolidine carboxamide derivatives as P2X7 modulators The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7... | 04/26/2011 |
| 7928133 | Compounds and compositions as hedgehog signaling pathway modulators The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smo... | 04/19/2011 |
| 7879896 | Dual-acting imidazole antihypertensive agents The invention is directed to compounds having the formula: wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT | 02/01/2011 |
| 7875645 | Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neu... | 01/25/2011 |
| 7842709 | Method for treating inflammatory diseases of the digestive tract A method for treating an inflammatory disease of the digestive tract, for example inflammatory bowel disease, in a subject comprises administering to the subject a therapeutically effective amount of a compound selected from the group consisting of (S,S)-2- [1-carbo... | 11/30/2010 |
| 7825150 | Compositions and methods for treating immunological and inflammatory diseases and disorders Methods and compositions for treating immunological and inflammatory diseases and disorders are disclosed. Particular methods and compositions comprise the administration of an agent that inhibits S1P lyase activity and at least one additional immunosuppressive and/... | 11/02/2010 |
| 7812048 | Glucokinase activators and methods of using same Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is ... | 10/12/2010 |
| 7767704 | Antiviral 4-aminocarbonylamino-substituted imidazole compounds The invention relates to the substituted imidazoles of formula (I) and to methods for producing the same, to their use in the treatment and/or prophylaxis of diseases and to their use for producing drugs for use in the treatment and/or prophylaxis of diseases, espec... | 08/03/2010 |
| 7750032 | Compounds and compositions as PPAR modulators The invention provides trisubstituted pyrazoles and imidazoles of Formula I: wherein L2, q, R13, R14, R15, R16, Z1 and Z2 are as described in the ... | 07/06/2010 |
| 7638546 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors. ... | 12/29/2009 |
| 7579369 | CB 1 receptor inverse agonists The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, m and X are as defined in the description and claims, and pharmaceu... | 08/25/2009 |
| 7560477 | Compounds active in sphingosine 1-phosphate signaling The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure: structure: | 07/14/2009 |
| 7459476 | Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (I) wherein X, R1, and R2 are define... | 12/02/2008 |
| 7432295 | Preparation of compounds useful for the detection of hypoxia Novel 18F-fluorine compounds useful for non-invasive imaging techniques such as PET, for detecting tissue hypoxia and methods for preparing them are disclosed. Novel intermediate compounds and methods for preparing them are also disclosed. Diagnostic kits... | 10/07/2008 |
| 7427619 | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cancer chemotherapy are disclosed. The pharmaceutical compositions of the present invention comprise riboflavin, effectors of the urea cyc... | 09/23/2008 |
| 7419998 | Therapeutic methods and compositions involving isoflavones Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R | 09/02/2008 |
| 7402600 | Nitroderivatives of cardiovascular agents Compounds or their salts having general formulas (I) and (II) wherein: s=is an integer equal to 1 or 2, preferably s=2; b0=0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C1 are two bi... | 07/22/2008 |
| 7371871 | Inhibitors of glutaminyl cyclase The present invention relates to compounds that act as inhibitors of QC including those represented by the general formulae 1 to 9: and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's di... | 05/13/2008 |
| 7368576 | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents The present invention provides new uses of DPIV-inhibitors of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, for treating conditions mediated by DPIV or DPIV-like enzymes, such as cancer and tumors. In a more pre... | 05/06/2008 |
| 7358369 | Radiolabelled phenylethyl imidazole carboxylic acid ester derivatives Halogenated carboxylic ester derivatives of phenylethyl imidazole, and their method of preparation are disclosed. Radio-halogenated forms of these compounds are ideally suited for positron-imaging of the adrenal glands, as it is known that these compounds demonstrat... | 04/15/2008 |
| 7351429 | Oral solid preparation The invention is to provide an oral solid pharmaceutical that is uniform in the content of KRP-197, having bladder-selective anticholinergic activity, being a therapeutic drug for pollakiuria and urinary incontinence, and being active with a very low dosage, that ca... | 04/01/2008 |
| 7341717 | Therapeutic targets for treatment of HCV infections, methods of treating HCV infections and compounds useful therefor The present invention relates to the human cellular protein glutathione peroxidase-gastrointestinal as a target for medical intervention against Hepatitis C virus (HCV) infections. Furthermore, the present invention relates to a method for the detection of compounds... | 03/11/2008 |
| 7335645 | Effectors of dipeptidyl peptidase IV for topical use The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formula wherein A is an amino acid having at least one f... | 02/26/2008 |
| 7326792 | Heterocyclic compounds as P2X7 ion channel blockers The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X... | 02/05/2008 |
| 7317107 | Imidazole 4-carboxamide compounds with adenosine deaminase inhibiting activity Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I): wherein R1 is optionally substituted aryl or optionally substituted heteroaryl, R2 is lower alkyl; R3 is hydroxy or protected hydroxy;... | 01/08/2008 |
| 7312199 | Process for the production of (−)-epigallocatechin gallate A process is provided for making (−)-epigallocatechin gallate (EGCG) by subjecting a green tea extract to chromatography on a macroporous polar resin, eluting EGCG from the resin with a polar elution solvent, optionally concentrating the eluate, optionally regener... | 12/25/2007 |
| 7312350 | Process for preparing arylalkynes The invention relates to a process for preparing arylvinyl halides and sulphonates and arylalkynes by reacting haloaromatics or aryl sulphonates with vinyl halides or sulphonates in the presence of a palladium catalyst and a base and, if appropriate, subsequent elim... | 12/25/2007 |
| 7304086 | Inhibitors of glutaminyl cyclase The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophre... | 12/04/2007 |
