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| Number | Title | Issue Date |
| 8093280 | Methods of preparing imidazole-based compounds Methods of preparing imidazole-based compounds are disclosed. Particular compounds are of formula I. ... | 01/10/2012 |
| 8080573 | Heterocycle substituted amide and sulfur amide derivatives as histone deacetylase (hdac) inhibitors The present invention related to compounds of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative dis... | 12/20/2011 |
| 7989484 | Dual-acting antihypertensive agents The invention relates to compounds having the formula: wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagoni... | 08/02/2011 |
| 7981915 | Methods for modulating PPAR biological activity for the treatment of diseases caused by mutations in the CFTR gene This invention features methods for treating diseases associated with mutations in the CFTR gene by administering PPAR agonists, specifically PPARγ, PPARα, and PPARδ agonists, PPAR inducers, and/or antioxidants. Also disclosed are screening methods for identifyin... | 07/19/2011 |
| 7977366 | Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. Th... | 07/12/2011 |
| 7932281 | Amine-based compound and use thereof Amine compounds represented by Formula (1) are efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis: ... | 04/26/2011 |
| 7902247 | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1: wherein n=1-4; | 03/08/2011 |
| 7863311 | Transmucosal veterinary composition comprising detomidine The present invention relates to a veterinary composition in a semisolid form adapted for transmucosal administration for providing sedation and analgesia in large animals such as horses and cattle. The semisolid transmucosal composition of the invention comprises d... | 01/04/2011 |
| 7825149 | Substituted imidazoles This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides. ... | 11/02/2010 |
| 7790762 | Compounds and methods for thiol-containing compound efflux and cancer treatment Methods for therapy of cystic fibrosis and other conditions such as cancer are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cell... | 09/07/2010 |
| 7786158 | Compounds as opioid receptor modulators The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the tr... | 08/31/2010 |
| 7776901 | Imidazolic compounds and use thereof as alpha-2 adrenergic receptors The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): ... | 08/17/2010 |
| 7741356 | Compounds as opioid receptor modulators The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the tr... | 06/22/2010 |
| 7718685 | 4,5-bis(4-methoxyphenyl)imidizole compound inducing differentiation of myoblasts or muscle fibers and pharmaceutical compositions including said compound The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells and a pharmaceutical composition including said compound. More specifically, it relates to 2-(2-fluorenyl)-4,5-bis(4-... | 05/18/2010 |
| 7714011 | Compositions to reduce congestion and methods for application thereof to the nasal membrane A gelled composition formulated to maintain an active ingredient in association with the nasal membrane for an extended period of time is provided. The gelled composition may be formulated as a decongestant or a sinus discomfort relieving agent. The invention furthe... | 05/11/2010 |
| 7714012 | Synthesis and biological activities of new tricyclic-bis-enones (TBEs) This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The inventors demonstrate the ability of these new TBEs to inhibit proliferatio... | 05/11/2010 |
| 7666893 | Method for treatment of neurodegenerative disorders A method for treatment of multiple sclerosis and other neurodegenerative diseases, disorders or conditions. An alkyl ester of imidazole carboxylic acid, preferably methyl 4-imidazolecarboxylate, is administered in a therapeutic amount. It is hypothesized that the al... | 02/23/2010 |
| 7655684 | Inhibitors of glutaminyl cyclase Compounds that act as inhibitors of QC including those represented by the general formulae 1 to 9: and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson d... | 02/02/2010 |
| 7652054 | Tricyclic compounds useful as angiotensin II agonists There is provided compounds of formula (I), wherein X1, X2, X3, Y4, Y1, Y2, Y3, Y4, Z1, Z2, R4 and R5 have meanings given in the descr... | 01/26/2010 |
| 7642279 | Atipamezole hydrochloride crystallization method A method of isolating atipamezole hydrocloride as a crystalline salt is provided. ... | 01/05/2010 |
| 7608633 | Heteroaryl-substituted acetone derivatives as inhibitors of phospholipase A The invention relates to novel heteroaryl substituted acetone derivatives which inhibit the enzyme phospholipase A2, pharmaceutical preparations containing these compounds and a method of producing these compounds. ... | 10/27/2009 |
| 7592362 | Substituted imidazoles This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides. ... | 09/22/2009 |
| 7550496 | Compositions and methods for treating cancer Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents. ... | 06/23/2009 |
| 7547718 | Substituted imidazoles This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides. ... | 06/16/2009 |
| 7544706 | Substituted imidazoles This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides. ... | 06/09/2009 |
| 7534805 | Imidazole derivatives, their preparation and their use as medicaments Novel imidazole compounds of the formula wherein the substituents are as defined in the application having antitumoral activity and use thereof. ... | 05/19/2009 |
| 7504426 | Heterocyclic compounds Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis. ... | 03/17/2009 |
| 7498354 | Pyrrolo[2,3-D]imidazoles for the treatment of hyperproliferative disorders or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of tumors and cancers. ... | 03/03/2009 |
| 7456207 | Vaginal pharmaceutical compositions and methods for preparing them Vaginal pharmaceutical compositions are described. These compositions contain (i) an active pharmaceutical ingredient selected from the group consisting of antimicrobial imidazoles and mixtures thereof, and (ii) a polysaccharide, wherein the pH of the composition is... | 11/25/2008 |
| RE40558 | Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P... | 10/28/2008 |
| 7432254 | Method for treating glaucoma IC Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation im... | 10/07/2008 |
| 7425638 | Cis-imidazolines The present invention provides compounds according to formula I having the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the interaction of MDM2 protein with... | 09/16/2008 |
| 7423015 | Antihelminthic drugs as a treatment for hyperproliferative diseases The present invention is directed to the use of benzimidazole derivatives for the treatment of tumors and in combination with tumor suppressor gene therapy. In a particular embodiment, treatment of p53-positive tumors with benzimidazole derivatives induces p53 expre... | 09/09/2008 |
| 7407989 | Compounds useful for modulating abnormal cell proliferation There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alk... | 08/05/2008 |
| 7405222 | Methods and compositions for treatment of erectile dysfunction Disclosed are methods and compositions for treatment of male sexual dysfunction. A method of treating male sexual dysfunction includes administering a pharmaceutical composition effective to cause said male to sustain an erection. The composition is formulated based... | 07/29/2008 |
| 7402602 | Imidazole derivatives modulating the sodium channels A method of treating cardiac rhythm disorders linked with neurodegenerating depression, bipolar disorders and irritable bowel disorders in warm-blooded animals in need thereof by administering a compound of the formula wher... | 07/22/2008 |
| 7396848 | Neurotrophin production/secretion promoting agent A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy gr... | 07/08/2008 |
| 7393857 | Use of 5-HTreceptor antagonists for treating musculoskeletal diseases The present invention relates to a new use for compounds having 5-HT3 (serotonin M) receptor antagonist activity, especially tropisetron, for the manufacture of a pharmaceutical composition for the treatment of a non-inflammatory local disease of the musc... | 07/01/2008 |
| 7390908 | Compounds effecting glucokinase The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or preventio... | 06/24/2008 |
| 7385063 | Method for preparing imidazole derivatives The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing a... | 06/10/2008 |
