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| Number | Title | Issue Date |
| 7358266 | Cyclopropyl and cyclobutyl epothilone analogs The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV wherein Ar is a radical represented by the following structure: and ... | 04/15/2008 |
| 7303759 | Compositions and methods for reducing blood and fluid loss from open wounds The invention described herein relates to methods for reducing and/or stopping bleeding or fluid loss from open wound, denuded tissue, or burned skin, comprising the step of applying to the open wound, denuded tissue or burned skin a gel-forming composition comprisi... | 12/04/2007 |
| 7294651 | Inhibition of exoprotein production using isoprenoid compositions Methods and compositions for inhibiting the production of exotoxins are disclosed. The compositions include an effective amount of an isoprenoid inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria. ... | 11/13/2007 |
| 7259267 | Difluorobenzo-1,3-dioxoles The invention relates to difluorobenzo-1,3-dioxoles, to a process for their preparation, and to their use for preparing medicaments and crop protection agents. ... | 08/21/2007 |
| 7244703 | Pharmaceutical compositions and methods for peptide treatment Compositions and methods for treating a patient with a pharmaceutically active peptide that combines a pharmaceutically active peptide, a permeation enhancer, and a carrier, are disclosed. ... | 07/17/2007 |
| 7244418 | Antimicrobial artificial nail composition and methods for preparing and using same A composition for forming an antimicrobial artificial nail, a method for preparing the same, and a method for treating a microbial infection of a nail plate are provided. The composition comprises a binder component; a filler component which polymerizes to form an a... | 07/17/2007 |
| 7238357 | Methods for treating ulcers and gastroesophageal reflux disease Methods for treating peptic ulcers and methods for treating gastroesophageal reflux disease by oral administration of a botulinum toxin. ... | 07/03/2007 |
| 7230000 | Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity ... | 06/12/2007 |
| 7135492 | 1,3-disubstituted-2- thioxo-imidazolidine-4,5-dione derivatives useful in the treatment of atherosclerosis Antiatherosclerotic compounds of Formula I are provided: wherein: R is lower alkyl, alkenyl, alkynyl, or —O—(CH2)n—COOR′; R′ is ... | 11/14/2006 |
| 7125863 | Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t... | 10/24/2006 |
| 7115720 | Therapeutic and diagnostic compounds, compositions, and methods The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a r... | 10/03/2006 |
| 7112559 | Thickened quaternary ammonium compound sanitizer The invention pertains to a thickened rinseless hand sanitizer composition comprising a quaternary ammonium compound. The invention also pertains to a method of applying to the skin of a human a thickened rinseless hand sanitizer composition that comprises a quatern... | 09/26/2006 |
| 7112561 | Pharmaceutical compositions and methods for insulin treatment Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed. ... | 09/26/2006 |
| 7105668 | Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity. ... | 09/12/2006 |
| 7101902 | 2-guanidinylimidazolidinedione compounds and methods of making and using thereof Disclosed herein are 2-guanidinylimidazolidinedione compounds having the structural formula A or B wherein R1 and R2 are each independently a hydrogen, halogen, alkyl, alkoxyl, amino, alkyla... | 09/05/2006 |
| 7097823 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/29/2006 |
| 7094885 | Skeletal-targeted radiation to treat bone-associated pathologies The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/22/2006 |
| 7087762 | Long-lasting antimicrobial reaction product of allantoin and formaldehyde containing a low level of free formaldehyde This invention relates to a reaction product of allantoin and formaldehyde made in a molar ratio of about 1:2.75–1:3.25, preferably 1:3, respectively, preferably under controlled pH (5.0 to 7.0) and temperature (40° to 85° C., preferably 50–60° C.) conditions... | 08/08/2006 |
| 7070759 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 07/04/2006 |
| 7071211 | Small organic molecules that increase the activity of gelatinase a in ocular cells Small organic molecules capable of effecting a “pharmacological trabeculocanalotomy” in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity in ocular cells by increa... | 07/04/2006 |
| 7055457 | Method for efficient milking A method for milking animals, particularly domesticated dairy animals, and most particularly dairy cattle, that improves milk/food sanitation, labor and cost efficiency, environmental friendliness, and throughput, that uses a wet prep and minimizes both interactions... | 06/06/2006 |
| 7045116 | Treatment of osteomyelitis with radiopharmaceuticals This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharm... | 05/16/2006 |
| 7041693 | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein L, Z0, R1, R4, R5, a... | 05/09/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 6982097 | Biocidal compositions and methods of using same This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using the biocidal compositions for the disinfection of water that may conta... | 01/03/2006 |
| 6977081 | Facial cream composition containing allantoin The present invention provides emollient creams composed of sulfur, sodium sulfacetamide and a botanically-derived anti-inflammatory ingredient. The creams are alcohol-free and have a pH at or above 7.0. ... | 12/20/2005 |
| 6919365 | Imidazolidinedione derivatives and use thereof as drugs The present invention is to provide an imidazolidinedione derivative and oxazolidinedione derivative represented by the following general Formula (I) having the chymase and/or tryptase inhibition activity [wherein R | 07/19/2005 |
| 6896897 | Flexible applicator for applying oil-in-water emulsion with improved stability A flexible applicator for applying an oil-in-water emulsion comprises: (1) an allantoin-containing oil-in-water emulsion; and (2) a flexible element that adsorbs or absorbs the emulsion such that the emulsion is applied to the skin of a patient on whom the flexible ... | 05/24/2005 |
| 6864274 | Allantoin-containing skin cream An allantoin-containing skin cream composition can comprise allantoin and at least one anionic or nonionic emulsifier that is substantially hydrophilic and is soluble in water. The pH of the composition is in a range of from about 3.0 to about 6.0; preferably, the p... | 03/08/2005 |
| 6794373 | Contraceptive methods using benzimidazolones This invention relates to cyclic combination therapies and regimens utilizing indoline compounds which are antagonists of the progesterone receptor and having the general structure: A is O, S, or NR4; B is a b... | 09/21/2004 |
| 6765003 | 3-Arylsulfonyl-2 (substituted methyl) propanoic acid derivatives as matrix metalloproteinase inhibitors Compounds which are 3-arylsulfonyl-2-methyl propanoic acid derivatives of formula (I): wherein X is HO—NH— or HO—, R1 is selected from phenyl, 4-chlorophenyl, 4-florophenyl, 4-cyanophenyl, benzamido (i.e., —NH—CO-Ph) and benzamido substituted on the termin... | 07/20/2004 |
| 6743434 | Carbonic emulsion skin care compositions and method for removing chemically bound residues and mineral deposits from hair The invention, in part, relates to skin care or hair care compositions containing a source of carbon dioxide. The carbon dioxide is conveniently entrained in a gel-network, or liquid crystalline phase, immediately prior to skin or hair application. A substantial por... | 06/01/2004 |
| 6706290 | Methods for eradication of nanobacteria Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The present invention provides methods for sterilizing articles contaminated ... | 03/16/2004 |
| 6673826 | Methods for treatment of inflammatory diseases An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emul... | 01/06/2004 |
| 6585967 | Adhesive treatment for tinea cruris A method of treating or preventing tinea cruris, commonly known as Jock Itch, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea cruris, optionally with at least one of an additional an... | 07/01/2003 |
| 6566384 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity.... | 05/20/2003 |
| 6531500 | Methods for treatment of inflammatory diseases An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is a water-in-oil emul... | 03/11/2003 |
| 6531497 | Epothilone derivatives and their synthesis and use The invention relates to epothilone analog represented by formula (I) wherein (i) R2 is absent or oxygen; "a" can be either a single or double bond; "b" can be either absent or a single bond; and "c" can be either absent or a single bond, with ... | 03/11/2003 |
| 6451831 | Agent for hypoalbuminaemia A highly safe and useful therapeutic agent for hypoalbuminaemia contains a hydantoin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof as an effective ingredient: ##STR1## wherein each of R1 and R2 | 09/17/2002 |
| 6423699 | Combination therapies using benzimidazolones This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: ##STR1## wherein: A is O, S, or NR4 ; B is ... | 07/23/2002 |
