Class 514/374 - 1,3-oxazoles (including hydrogenated)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the five-membered hetero ring is
No. of patents: 1145
Last issue date: 12/29/2009

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Number	Title	Issue Date
7638544	Dimeric small molecule potentiators of apoptosis Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an ef...	12/29/2009
7629371	Cosmetic use of a composition containing at least one oxazoline, serving as an active substance, as a slimming product and/or for preventing and/or treating cellulite The invention relates to the cosmetic use of a composition containing at least one oxazoline, serving as an active substance, as a slimming product, and to an associated cosmetic treatment method. The invention also relates to the cosmetic use of a composition conta...	12/08/2009
7618991	Heterocyclic derivatives, preparation and therapeutic use thereof The invention concerns compounds of formula (I): Wherein X, Y, R1, R2, R3 and R4 are as described herein. The invention also concerns a method for preparing same and the therapeut...	11/17/2009
7598281	Arylcycloakyl-substituted alkanoic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistence and the like comprising acetic acid...	10/06/2009
7595334	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optional...	09/29/2009
7569594	Analogs of leucascandrolide A The present invention describes leucascandrolide analogs of the formula (I), intermediates of the formula (III), pharmaceutical compositions containing the same, methods for preventing cell proliferation, and methods for treating cancers and other proliferative dise...	08/04/2009
7538131	2-{-3-′2-(phenyl)-oxazol-4-ylmethoxymethyl-cyclohexylmethoxy}-propionic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistance and the like comprising acetic acid...	05/26/2009
7538130	Hindered amine light stabilizer, methods of making, and compositions A compound in which n is 0, 1, 2, or 3; R1, R2, R7, and R8 are each independently alkyl group, including cycloalkyl, an alkylaryl group, or an aryl group, optionally with one or m...	05/26/2009
7456205	Benzopyran compounds, process for preparing the same and their use The invention relates to the benzopyran compounds of formula (I), or the salts thereof, in which, the bond between 3 and 4 positions is a single or double bond; R1 represents a hydrogen atom or a C1-6 alkyl that can be substituted; R2	11/25/2008
RE40558	Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P...	10/28/2008
7439259	Thiazole derivatives for treating PPAR related disorders The present invention provides combinations of compounds of formula (I) and other therapeutic agents for the treatment of PPAR related diseases. ...	10/21/2008
7435751	7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropy...	10/14/2008
7432290	Inhibitors of IMPDH enzyme The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH e...	10/07/2008
7432294	Pharmaceutical formulations Improved pharmaceutical compositions are provided comprising one or more solubilized HIV protease inhibiting compounds having improved solubility properties in a medium and/or long chain fatty acid, or mixtures thereof, a pharmaceutically acceptable alcohol, and wat...	10/07/2008
7432293	Heterocyclic compounds useful as Nurr-1 activators The present invention relates to compounds of formula (I): wherein R1 is hydroxy, C1-4 alkoxy, amino, C1-4 alkyl-amino, di C1-4alkylamino, benzyloxy or C2-C7 alkanoyl, R2 is C1-4	10/07/2008
7427636	Inosine monophosphate dehydrogenase inhibitory phosphonate compounds The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such comp...	09/23/2008
7419967	Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T...	09/02/2008
7402597	Activator of peroxisome proliferator-activated receptor δ A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B1 represents N, etc.; B...	07/22/2008
7399765	Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar1—Ar2 (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute...	07/15/2008
7399777	Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals Diarylcycloalkyl derivatives and their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds include those of formula I, in which the radicals are as defined, and their phy...	07/15/2008
7396848	Neurotrophin production/secretion promoting agent A neurotrophin production/secretion promoting agent which comprises an azole derivative of the formula: wherein R1 represents a halogen atom, a heterocyclic group which may optionally be substituted, a hydroxy gr...	07/08/2008
7396838	Use of 1H-indol-3-yl-2-oxoacetamide compounds A method of treating cancer including administering to a subject in need thereof an effective amount of a compound of the formula 1: wherein R1, R2, R3, R4, and n are as defined h...	07/08/2008
7396833	Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of ...	07/08/2008
7396847	Oxazolidinone and/or isoxazoline as antibacterial agents Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, and compounds as shown in (I) wherein C is for example wherein A and...	07/08/2008
7390824	Method for treating diabetes employing an aP2 inhibitor and combination A method is provided for treating diabetes and related diseases, especially Type II diabetes, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin. ...	06/24/2008
7390908	Compounds effecting glucokinase The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or preventio...	06/24/2008
7384964	Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (...	06/10/2008
7384947	Fused tricyclic heterocycles useful for treating hyper-proliferative disorders This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders. ...	06/10/2008
7378421	Chromenone derivatives Novel compounds of the formula I in which R1, R2, R3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for...	05/27/2008
7371777	Cyclic compound and PPAR agonist The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. ...	05/13/2008
7368471	Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) This invention provides compounds of the formula: wherein: X is a chemical bond, —CH2— or —C(O)—; R1 is alkyl, cycloalkyl, —CH2-cycloalkyl, pyridinyl, —CH2-pyridinyl, ...	05/06/2008
7368578	Five-membered heterocyclic compounds The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom...	05/06/2008
7365084	Cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals Provided herein are cycloalkyl-substituted amino acid derivatives, processes for their preparation and their use as pharmaceuticals. ...	04/29/2008
7361657	Respiratory syncytial virus replication inhibitors This invention concerns the use of compounds of formula (I) wherein −a1=a2−a3=a4—is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—C...	04/22/2008
7358254	Method for treating atherosclerosis employing an aP2 inhibitor and combination A method is provided for treating atherosclerosis and related diseases, employing an aP2 inhibitor or a combination of an aP2 inhibitor and another antiatherosclerotic agent, for example, an HMG CoA reductase inhibitor such as pravastatin. ...	04/15/2008
7351726	Substituted oxadiazolidinediones The present invention relates generally to substituted oxadiazolidinediones and methods of using them. ...	04/01/2008
7351728	Oxazolyl-aryloxyacetic acid derivatives and their use as PPAR agonists Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl, R2 is H...	04/01/2008
7351730	Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8,...	04/01/2008
7348349	Oxazole derivatives The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present ...	03/25/2008
7348351	Substituted 3-alkyl and 3-arylalkyl -indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) The invention formula substituted 3-alkyl and 3-arylalkyl 1H indol-1yl acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor (PAI-1) useful for treating fibrinolytic disorders, the compounds having the structure ...	03/25/2008

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Class 514/374 - 1,3-oxazoles (including hydrogenated)