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Patent No. 6293874

User-operated amusement apparatus for kicking the user's buttocks

An apparatus including a user-operated and controlled apparatus for self-infliction of repetitive blows to the user's buttocks by a plurality of elongated arms bearing flexible extensions that rotate under the user's control.

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Class 514/372 - 1,2-thiazoles (including hydrogenated)


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the five-membered hetero ring is
No. of patents: 735
Last issue date: 03/20/2012


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NumberTitleIssue Date
8138211Isothiazolyloxyphenylamidines and their use as fungicides
The present invention relates to isothiazolyloxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms, and also to a composition for this purpose w...
03/20/2012
8138212Synergistic microbicidal compositions
This invention relates to synergistic combinations of selected isothiazolin-3-one microbicides in combination with a second microbicide or formulation ingredient or raw material. The combinations have greater efficacy than would be expected from combinations of the ...
03/20/2012
8119670Antimicrobial composition useful for preserving wood
Antimicrobial compositions useful for preserving wood, and comprising a variety of antimicrobial compounds. ...
02/21/2012
8093277Antimicrobial composition useful for preserving wood
Antimicrobial compositions useful for preserving wood, and comprising a variety of antimicrobial compounds. ...
01/10/2012
8088807Microbicidal composition
A microbicidal composition comprising relatively high levels of a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one; a metal nitrate; and water. The composition optionally contains magnesium chloride. ...
01/03/2012
8076363Isothiazolone-containing preservative with improved effectiveness
The invention relates to a preservative which 5 comprises a) one or more isothiazolones and b) one or more glycerol monoalkyl ethers, to the use of the preservatives for microbicidal finishing of cosmetic and pharmaceutical products, and to corresponding microbicida...
12/13/2011
80674523-hydroxyisothiazole-4-carboxamidine derivatives as CHK2 inhibitors
This invention provides compounds of Formula I which are inhibitors of Chk2 and are useful as a radiation protection agents in anticancer radiotherapy. A method of modulating Chk2 in vitro includes treating a substrate with Chk2 in the presence of compounds of formu...
11/29/2011
8058298Antimicrobial composition useful for preserving wood
Antimicrobial compositions useful for preserving wood, and comprising a variety of antimicrobial compounds. ...
11/15/2011
8058297Compounds for the treatment of proliferative disorders
The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 ...
11/15/2011
7981912Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof
The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metab...
07/19/2011
7960419Substituted carboxamides
This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain. ...
06/14/2011
7947718Isoxazole compounds as histamine Hmodulators
Certain isoxazole compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases. ...
05/24/2011
7939554Protein phosphatase inhibitors
A method of inhibiting protein tyrosine phosphatase in a subject includes administering to the subject a therapeutically effective amount of at least one benzo-1,4-quinone, phenyl isothiazolone, or analog thereof to the subject. ...
05/10/2011
7897629Therapeutic compounds
Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ...
03/01/2011
7872033Compounds as cannabinoid receptor ligands
The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising...
01/18/2011
7781466Preparation for the fungicidal and algicidal finish of alkaline coating compositions
The invention relates to a preservative comprising at least one isothiazolone, at least one quaternary ammonium compound, and at least one stabilizer selected from the group of sulphite salts, hydrogen sulphite salts, sulphite-releasing compounds and hydrogen-sulphi...
08/24/2010
7772262Substituted benzoylguanidines, method for production and use thereof as medicament or diagnostic and medicament comprising the same
The present invention relates to substituted benzoylguanidines of the formula I: in which R1 to R8 and X and Y are as described in the specification, and their pharmaceutically acceptable salts are substituted acylguanidine...
08/10/2010
7745469Fungicidal active substance combinations
The invention relates to novel fungicidally active compound combinations of 2′-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and active compounds listed in the disclosure. ...
06/29/2010
7741351Compounds which potentiate glutamate receptor and uses thereof in medicine
This case discloses compounds of formula (I) wherein R1 is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino or diC1-4alkylamino; R2 and R3, which may be the same ...
06/22/2010
7652047Phenylamino isothiazole carboxamidines as MEK inhibitors
The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones. ...
01/26/2010
7572821Compounds for the treatment of proliferative disorders
The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 ...
08/11/2009
7560476Microbicidal composition
A microbicidal composition containing: (a) at least one non-halogenated 2-alkyl-4-isothiazolin-3-one selected from substituted and unsubstituted 2-(C1-C4)alkyl-4-isothiazolin-3-ones; and (b) at least one of 2,2′-dithiobis(N-methylbenzamide) a...
07/14/2009
7442240Alkoxylpropylisothiazolinone and preparation method and use thereof
An alkoxylpropyl isothiazolinone of formula: C6H6Cl2NO2SR, in which R is CH3, CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2
10/28/2008
RE40558Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as P...
10/28/2008
7435748Gamma-secretase inhibitors
Compounds of formula I: inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease. ...
10/14/2008
7405218Isothiazole derivatives useful as anticancer agents
The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3 are as defined herein....
07/29/2008
7399765Substituted diazabicycloalkane derivatives
Compounds of formula (I) Z-Ar1—Ar2  (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substitute...
07/15/2008
7396846Growth hormone secretagogues
This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in thes...
07/08/2008
7396838Use of 1H-indol-3-yl-2-oxoacetamide compounds
A method of treating cancer including administering to a subject in need thereof an effective amount of a compound of the formula 1: wherein R1, R2, R3, R4, and n are as defined h...
07/08/2008
7384929N-aryl azaspiroalkene and azaspiroalkane compounds and methods of preparation and use thereof
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl or heteroaryl azaspiroalkene/alkane compounds, prodrugs or metabolites of these compounds, or pharmaceutically acceptab...
06/10/2008
7371771Alkenyl-substituted spirocyclic sulfamides as inhibitors of gamma-secretase
Compounds of formula (I) are disclosed: wherein R4 is an alkenyl group of defined structure. The compounds inhibit gamma-secretase, and hence are useful for treatment of Alzheimer's disease. ...
05/13/2008
7365196Sulphonamido-substituted bridged bicycloalkyl derivatives
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ...
04/29/2008
7361657Respiratory syncytial virus replication inhibitors
This invention concerns the use of compounds of formula (I) wherein −a1=a2−a3=a4—is a radical of formula —CH═CH—CH═CH—, —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH—, —CH═CH—C...
04/22/2008
7357947Bone graft material incorporating demineralized bone matrix and lipids
One embodiment of the invention is demineralized bone putty composition comprises: (1) demineralized bone matrix (DBM); and (2) a lipid fraction selected from the group consisting of lecithin and a mixture of lecithin and triglycerides containing unsaturated fatty a...
04/15/2008
7348440Mitotic kinesin inhibitors
The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comp...
03/25/2008
7342039Substituted indole oximes
The present invention relates to substituted indole oximes and methods of using them. ...
03/11/2008
7338969Modulation of pathogenicity
The present invention relates to the use of compounds of the general Formula (XIII): wherein A7 is C═O, C═S, SO2, CH—OR13, C═NR12...
03/04/2008
7326695Anti-bacterial agents based upon oxoanion binding
Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independen...
02/05/2008
7297193Wax-biocide wood treatment
A method for preserving wood by contacting wood with an aqueous composition comprising a paraffin wax, at least one nonionic surfactant, and at least one organic wood preservative. ...
11/20/2007
7291276Controlled production and release of oxygen activated biocide into holding tanks for RV's, boats and the like
Waste in a black or gray water holding tank is treated by an oxygen activated biocide by the addition of tetra acetyl ethylene diamine (TAED) and a peroxygen compound. Hydrogen peroxide and/or peracetic acid are released over a period of time and thus maintained in ...
11/06/2007
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