Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8188126 | Imidazolic compounds and use thereof as alpha-2 adrenergic receptors The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is h... | 05/29/2012 |
| 8124632 | Alkylsulfonyl-substituted thiazolide compounds A new class of alkylsulfonyl-substituted thiazolide compounds is described. These compounds show strong activity against hepatitis virus. ... | 02/28/2012 |
| 8119669 | Substituted phenoxy N-alkylated thiazolidinediones as estrogen related receptor-α modulators The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spon... | 02/21/2012 |
| 8106079 | Intermediate of 6-substituted-1-methyl-1-H-benzimidazole derivative and method for producing same A compound having the following formula (III) wherein R2 is hydrogen, alkyl, cycloalkyl, phenyl or a 5- or 6-membered heterocyclic, and X is oxygen, sulfur or nitrogen, and a method for preparing said compound. | 01/31/2012 |
| 8067450 | Thiazolidinedione analogues for the treatment of metabolic diseases The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases. Formula (I), wherein: each of R1 and R4 is independently selected from H, halo, aliphatic, and alkoxy, ... | 11/29/2011 |
| 8063079 | Cyclopropyl compounds A compound of the formula: and pharmaceutical compositions for the treatment of diabetes. ... | 11/22/2011 |
| 8058295 | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions a... | 11/15/2011 |
| 7973063 | Methods for activating PPAR gamma-type receptors Novel biaromatic compounds having the following structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine, in particular in dermatology as well as in t... | 07/05/2011 |
| 7973062 | Androgen receptor-ablative agents Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating or preventi... | 07/05/2011 |
| 7947717 | Inhibitors of lethal factor protease The invention provides compounds that can efficiently and specifically inhibit bacterial toxins, such as inhibit the lethal factor (LF) protease activity of anthrax toxin and/or botulinum neurotoxin type A. The invention also provides methods for inhibiting protease... | 05/24/2011 |
| 7858650 | Medicinal composition for inhalation A medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist topically exhibits a prolonged bronchodilating and antiinflammatory effects. Namely, the medicinal composition for inhalation containing a continuous-release type p... | 12/28/2010 |
| 7846953 | Substituted phenoxy thiazolidinediones as estrogen related receptor-α modulators The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spon... | 12/07/2010 |
| 7825143 | Method for controlling the yeast-to-filamentous growth transition in fungi A method for controlling yeast-to-filamentous growth transition in fungi comprising contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit the yeast-to-filamentous growth transition, wherein the anti-fungal small mole... | 11/02/2010 |
| 7812043 | N-heteroaryl indole carboxamides and analogues thereof, for use as glucokinase activators in the treatment of diabetes This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The compounds are of the general formula (I) | 10/12/2010 |
| 7807700 | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7,... | 10/05/2010 |
| 7795286 | Silane esters and amides of 2-oxothiazolidine-4-carboxylic acid, and cosmetic uses thereof The present invention relates to novel compounds of formula (1) and also to cosmetic compositions containing them and to the cosmetic uses thereof, in particular for protecting the skin against UV-induced oxidative stress. ... | 09/14/2010 |
| 7795287 | Therapeutic substituted hydantoins and related compounds A compound having a structure is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 09/14/2010 |
| 7781465 | Therapeutic oxazolidinones and thiazolidinones Disclosed herein is a compound represented by a formula Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 08/24/2010 |
| 7781464 | Heterocyclic diphenyl ethers The present invention relates to novel heterocyclic diphenyl ether and diphenyl amine compounds, derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof... | 08/24/2010 |
| 7767701 | Chemical compounds This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins. ... | 08/03/2010 |
| 7732470 | Compositions and methods for the treatment of renal and cardiovascular disease Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the us... | 06/08/2010 |
| 7718680 | Inhibition of lethal factor protease activity from anthrax toxin The present invention provides compounds that efficiently and specifically inhibit lethal factor (LF) protease activity of anthrax toxin. ... | 05/18/2010 |
| 7718681 | 5-(1,3-Diaryl-1H-pyrazol-4-ylmethylene)-thiazolidine,2,4-dione derivatives useful as anticancer agent The present invention relates to a 5-(1,3-diaryl-1H-pyrazol-4-ylmethylene)-thiazolidine-2,4-dione derivative or its pharmaceutically acceptable salts thereof, a method for preparing the same and an anticancer agent composition comprising the same as an active ingred... | 05/18/2010 |
| 7718682 | Heterocyclic analogs of diphenylethylene compounds Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II di... | 05/18/2010 |
| 7714005 | Small molecule Bcl-xL/Bcl-2 binding inhibitors Bcl-xL/Bcl-2 binding inhibitors useful in the treatment of unwanted proliferating cells, including cancers and precancers, in subjects in need of such treatment. Also provided are methods of treating a subject having unwanted proliferating cells comprising administe... | 05/11/2010 |
| 7662842 | Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides according to formulae (I) and (II) are disclosed where the various substituent groups are as defined in the specification... | 02/16/2010 |
| 7659295 | Therapeutic substituted thiazolidinones, oxazolidinones, and related compounds A compound having a structure is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ... | 02/09/2010 |
| 7638543 | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions a... | 12/29/2009 |
| 7635708 | Methods and pharmaceutical compositions for inhibiting tumor cell growth The present invention is based on the finding that activation of PPARγ plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPARγ agonists, such as thiazolidinedione ligands (TZDs), ... | 12/22/2009 |
| 7595333 | Agent for improving acidosis An agent for improving ketosis which comprises an insulin sensitizer, which has an excellent action and low toxicity. ... | 09/29/2009 |
| 7566732 | Rhodanine compositions for use as antiviral agents This invention describes compounds and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. In parti... | 07/28/2009 |
| 7521466 | Dipeptide phenyl ethers Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune disease... | 04/21/2009 |
| 7521465 | Diphenyl ether derivatives Novel diphenyl ether derivatives are provided that exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associ... | 04/21/2009 |
| 7514462 | ω-Cycloalkyl 17-heteroaryl prostaglandin Eanalogs as EP-receptor agonists The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the following formula I: | 04/07/2009 |
| 7514461 | Chroman derivatives The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorder... | 04/07/2009 |
| 7439260 | 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents. | 10/21/2008 |
| 7439248 | Pharmaceutical composition and the process for its preparation The present invention provides a new stable pharmaceutical composition containing 5-[[4-[3-Methyl-4-oxo-3,4-dihydro-2-quinazolinyl]methoxy]phenyl-methyl]thiadiazolidine-2,4-dione as active ingredient. ... | 10/21/2008 |
| 7439242 | PPARγ modulators Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 10/21/2008 |
| 7435828 | Thiazolidin-4-one derivatives The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4- one derivatives notably for... | 10/14/2008 |
| 7407978 | Heterocyclic analogs of diphenylethylene compounds Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II di... | 08/05/2008 |
