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| Number | Title | Issue Date |
| 8138210 | Substituted indanyl sulfonamide compounds, their preparation and use as medicaments The present invention refers to new indanyl sulphonamide compounds with general formula (I), as well as to their preparation procedure, their application as medicine and the pharmaceuticals composition which they are made up of. ... | 03/20/2012 |
| 8080569 | Imidazo[2,1-b]thiazoles and their use as pharmaceuticals The present invention relates to derivatives of imidazo[2,1-b]thiazoles of formula I, in which R, R1 to R3 and n have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide (NO) s... | 12/20/2011 |
| 7671078 | Isothiourea derivatives of imadazo[2,1-b]Thiazoles and 5,6-dihydro derivatives thereof useful as CXCR4 chemokine receptor inhibitors The invention relates to isothiourea derivatives of formula I: wherein R1 is a residue of one of the following structures: where the variables are as defined in the cla... | 03/02/2010 |
| 7662841 | Imidazothiazole derivatives and process for producing the same The present invention relates to compounds of formula (I) and a process for producing the same. In formula (I), X represents a halogen atom, and R1 represents group —COR2 wherein R2 represents group OM or C1-12 alkyloxy wherein M r... | 02/16/2010 |
| 7419993 | Triazolo-epothilones The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B. ... | 09/02/2008 |
| 7351481 | Imidazole ring-containing compound and organic electroluminescence display device The present invention is related to an imidazole ring-containing compound and an organic electroluminescence (EL) display device using the same. In particular, the imidazole ring-containing compound may be used alone or in combination with a dopant as a material for... | 04/01/2008 |
| 7351732 | Cycloalkanedione derivatives, method for the production thereof and their pharmacological applications New cycloalkanedione derivatives that are serotonin (5-hydroxytriptamine, 5-HT) 5-HT1A receptor subtype agonists and, consequently, they are useful in the treatment of pathological states for which an agonist of these receptors is indicated. They a... | 04/01/2008 |
| 7345069 | Oxidative activation and episulfonium ion-mediated DNA alkylation-based anticancer The present invention relates to TG-25 and/or analogs thereof and their use of TG-25 in the treatment of cancer. TG-25 inhibits the growth of prostate cells by inhibiting DNA synthesis, more particularly by DNA cleavage. ... | 03/18/2008 |
| 7288559 | Carboxamide spirohydantoin CGRP receptor antagonists The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pha... | 10/30/2007 |
| 7230021 | Potent, simplified derivatives of pateamine A The present invention provides a compound of Formula I, all of its related stereoisomers, and their pharmaceutically acceptable salts, wherein A—B, K, Q, X, Y, Z, R and R1 are as defined in Claim 1. The present invention also provides processes for the prep... | 06/12/2007 |
| 7220756 | N-sulfonylheterocyclopyrrolyl-alkylamine compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor ... | 05/22/2007 |
| 7214802 | Anti-cytokine heterocyclic compounds Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chr... | 05/08/2007 |
| 7172767 | Opioid agonist / antagonist combinations The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide ... | 02/06/2007 |
| 7173013 | Treatment of tuberculosis using immunomodulator compounds Tuberculosis in an animal is treated by administration of a therapeutically effective amount of an immunomodulator of formula A. In formula (A), n is 1 or 2, R is hydrogen, acyl, alkyl or a peptide fragment, and X is an aromatic or heterocyclic amino acid or a deriv... | 02/06/2007 |
| 7153873 | Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: addition products thereof with acids, and methods for preparing the salts and addition products. Also disclosed are pharmaceut... | 12/26/2006 |
| 7125863 | Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t... | 10/24/2006 |
| 7105550 | 2,4-disubstituted thiazolyl derivatives This invention concerns the use of a compound of formula (I′) a N-oxide, pharmaceutically acceptable addition salt, quaternary amine and stereochemically isomeric form thereof, wherein Q is optionally substitut... | 09/12/2006 |
| 7087626 | Pyrrole derivatives as pharmaceutical agents Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ... | 08/08/2006 |
| 7084137 | Thiazines and thiazoles as agents for protecting materials The novel and known thiazines and thiazoles of the formula (I) in which R1, R2 and n are as defined in the description, are highly suitable for use as biocides for protecting in... | 08/01/2006 |
| 7041694 | Cyclooxygenase-2 inhibition Selective inhibitors of cyclooxygenase-2 are used to treat liver disease and in combination with anti-viral drugs to treat virus-caused liver disorders. Selective inhibitors of cyclooxygenase-2 which also inhibit the synthesis of cyclooxygenase-2 improve over the ef... | 05/09/2006 |
| 7022701 | Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 04/04/2006 |
| 7012087 | p53 inhibitors and therapeutic use of the same The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed. ... | 03/14/2006 |
| 7008957 | Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments The invention relates to compounds of the formula I in which the radicals have the stated meanings, their stereoisomeric forms and their physiologically tolerated salts and process for their preparation. The com... | 03/07/2006 |
| 6962914 | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 11/08/2005 |
| 6900160 | Triazolo-epothilones The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B. ... | 05/31/2005 |
| 6875765 | Arylsulfonamide ethers, and methods of use thereof The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are described. In one embodiment, the compound is described by the generalized s... | 04/05/2005 |
| 6838462 | Insecticidal azoles The present invention relates to novel heterocyclic compounds of formula (I) where A, R1, R2, Y, Z, and n are defined in the disclosure, to processes for their preparation, and to their use as crop protection agents, i... | 01/04/2005 |
| 6821993 | Triazepine derivatives as neurotrophic agents This invention relates to a series of triazepines of Formula I and II, and pharmaceutical compositions containing them. The compounds of the invention have neurotrophic activity and are useful in the treatment and prev... | 11/23/2004 |
| 6794359 | Vertebrate intestinal protein which absorbs cholesterol, its inhibitors and mehtod of identifying the same The invention relates to a vertebrate intestinal protein which absorbs cholesterol. It was possible to identify the protein by means of high-affinity crosslinking compounds. The invention further relates to this use of the protein for carrying out a method for ident... | 09/21/2004 |
| 6770642 | Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 08/03/2004 |
| 6730686 | Methods for inhibiting oxidative modification of proteins The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions. The instant invention also ... | 05/04/2004 |
| 6696441 | Inhibition of p53-induced stress response The present invention provides compounds that act to suppress p53 activity in mammalian cells, and a method to effectively suppress p53 activity in the cells of a mammal subject to a stress or pathology that is ameliorated by such suppression.... | 02/24/2004 |
| 6670128 | Transfusion medicine leukodepletion filter devices as a source of genetic material for genotyping studies The present invention provide methods for utilizing spent leukodepletion filter devices as a source of material for the isolation and analysis of genomic DNA (gDNA), including polymorphism, genotyping, and pharmacogenomic studies. Cellular retentate with ... | 12/30/2003 |
| 6586426 | ଲ-sheet mimetics and use thereof as protease inhibitors There are disclosed ଲ-sheet mimetics and methods relating to the same for imparting or stabilizing the ଲ-sheet structure of a peptide, protein or molecule. In one aspect, the ଲ-sheet mimetics are covalently attached at the end or within ... | 07/01/2003 |
| 6586419 | Phototherapeutic inactivation of ocular viruses A method for inactivating ocular viral pathogens and for treating associated lesions on tissue by means of selectively activating a tissue-associated photosensitizing agent with light. The photosensitizing agent, preferably tin ethyl etiopurpurin, is admi... | 07/01/2003 |
| 6586452 | C1 to C4 side chain modified nodulisporic acid analogs The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.... | 07/01/2003 |
| 6440963 | Use of selective COX-2 inhibitors for the treatment of urinary incontinence The treatment of neuromuscular dysfunction of the lower urinary tract by compounds which selectively inhibit the COX-2 isozyme is described. The compounds concerned inhibit the COX-2 isozyme with a potency at least 10-fold, and preferably at least 100-fol... | 08/27/2002 |
| 6395724 | Multibinding inhibitors of cyclooxygenase-2 Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently ... | 05/28/2002 |
| 6380228 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this inv... | 04/30/2002 |
| 6362191 | Aminometyl oxooxazolidinyl benzene derivatives The invention concerns compounds of formula (I), ##STR1## wherein: A is a 5 membered heteroaryl ring, a bicyclic benzo system containing such a 5 membered heteroaryl ring or a bicyclic or tricyclic heteroaryl ring system with at least one bridgehead nitro... | 03/26/2002 |
