Quotables
"The idea that cavalry will be replaced by these iron coaches is absurd. It is little short of treasonous."
Aide-de-camp to Field Marshal Haig ; At a tank demonstration, 1916
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8173688 | Thiazole compounds, and compositions and methods using same The present invention provides, in part, compounds and compositions including a thiazole moiety, that may be useful, for example, for treating cancers, for example kidney cancer. ... | 05/08/2012 |
| 8088805 | Inhibitors of histone deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and cond... | 01/03/2012 |
| 8058294 | Pharmaceutical salts of N-[2-(diethylamino)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-3-[2-(1-napthyl)ethoxy]propanamide A pharmaceutically acceptable salt of N-[2-(Diethylamino)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-3-[2-(1-naphthyl)ethoxy]propanamide provided it is not the dihydrobromide or dihydrochloride salt; and the use of such a co... | 11/15/2011 |
| 8044078 | Amino-alkyl amide derivatives as CCR3 receptor ligands The invention relates to a compound of the general formula (I), as defined herein which is useful for the treatment of a pathology in a patient wherein a CCR3 receptor plays a role in the development of the pathology, and p... | 10/25/2011 |
| 8017637 | Inhibitors of cdc phosphatases A subject of the present invention is novel compounds comprising 2 or 3 benzothiazole-4,7-dione- or benzooxazole-4,7-dione-type units, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment... | 09/13/2011 |
| 8008331 | Benzothiazol-2-one derivatives as lipase and phospholipase inhibitors The invention relates to benzothiazol-2-one derivatives of general formula (I) with the meanings indicated in the description, the pharmaceutically usable salts thereof, and the use thereof as medicinal substances. ... | 08/30/2011 |
| 7968576 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ... | 06/28/2011 |
| 7960418 | 4β-amino podophyllotoxin congeners as potential anticancer agents and a process for the preparation thereof The present invention provides new class of 4β-[4″-(1″,3″-benzothiazole-2″-yl)anilino]podophyllotoxin analogues having the structural formula as follows (4). Where R═H or CH3; R1═H, halogen,... | 06/14/2011 |
| 7947716 | N-sulfonylaminocarbonyl containing compounds Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a substrate. The s... | 05/24/2011 |
| 7932277 | Peptide inhibitors of hepatitis C virus replication The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula II, as well as compositions, including pharmaceutical ... | 04/26/2011 |
| 7897627 | Heteroaryl derivatives as orexin receptor antagonists The present invention relates to compounds of formula wherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or di... | 03/01/2011 |
| 7875639 | Compounds as cannabinoid receptor ligands and uses thereof The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and ... | 01/25/2011 |
| 7868029 | Process for the preparation of 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiazoles from cyclohexanes and cyclohexanones as intermediates The present invention relates to processes for the preparation of 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiazoles (5a) from cyclohexanes (2a) and cyclohexanones (3a) as intermediate. ... | 01/11/2011 |
| 7863305 | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitors Compounds of formula I: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd | 01/04/2011 |
| 7838543 | MCH receptor antagonists The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar1, L1, R1, q, X, R2, R3, R4, and R5 are as defined, or a pharmaceutically acce... | 11/23/2010 |
| 7820703 | Lysophosphatidic acid receptor selective antagonists The present invention is directed to compositions comprising lysophosphatidic acid analogs and methods of using such analogs as agonist or antagonists of LPA receptor activity. In addition the invention is directed to LPA receptor agonists that vary in the degree of... | 10/26/2010 |
| 7812042 | Pharmaceutical compositions and therapeutic applications for the use of a novel vitamin Bderivative, N-acetyl-L-cysteinylcobalamin Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiol... | 10/12/2010 |
| 7803824 | Use of inhibitors of Jun N-terminal kinases to treat glaucoma Compositions and methods for lowering IOP and/or providing neuroprotection are disclosed. The compositions and methods are particularly directed to the use inhibitors of Jun N-terminal kinases (JNK) to lower IOP and/or provide neuroprotection. ... | 09/28/2010 |
| 7795284 | 4,7-dioxobenzothiazole-2-carboxamide derivatives, their preparation and their therapeutic uses A subject of the present invention is 4,7-dioxobenzothiazole-2-carboxamide derivatives, which inhibit the cdc25 phosphatases, in particular cdc25-C phosphatase. These compounds can in particular be used in the treatment of cancer. ... | 09/14/2010 |
| 7786152 | Compound A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl, R5 is a h... | 08/31/2010 |
| 7786151 | Therapeutic composition of treating abnormal splicing caused by the excessive kinase induction The present invention provides a composition of treating, preventing abnormal splicing caused by the excessive kinase induction, which comprises TG003 and a method using the same of treating, preventing abnormal splicing caused by the excessive kinase induction.... | 08/31/2010 |
| 7772261 | Pyrazolo[4,3-]thiazole derivatives, and preparation and therapeutic application thereof The disclosure relates to a compound of formula (I): in which: R1, R2, R3 and R4 are as described in the specification, to compositions containi... | 08/10/2010 |
| 7759376 | Preparation and use of biphenyl-4-yl-carbonylamino acid derivatives for the treatment of obesity This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases. ... | 07/20/2010 |
| 7723366 | Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases The present invention relates to methods of treatment of certain metabolic diseases, and to the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In ... | 05/25/2010 |
| 7709510 | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In parti... | 05/04/2010 |
| 7709511 | Benzothiazolone derivatives The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4, R5, R6, R7, R7a, R7b, A, D, m and n are as defined in ... | 05/04/2010 |
| 7674809 | Anti-inflammatory and analgesic heterocyclic amidines that inhibit nitrogen oxide (NO) production Heterocyclic amidines with anti-inflammatory and analgesic activity that inhibit nitrogen oxide production, of formula (I): in which: G1 and G2 are hydrogen, halogen,... | 03/09/2010 |
| 7666886 | Compounds and methods for the diagnosis and treatment of amyloid associated diseases The invention is in general directed to compounds and methods for diagnosing, preventing or alleviating the symptoms of amyloid-associated diseases, for example, neuronal diseases, such as, for example, Alzheimer's disease, methods of screening for compounds useful ... | 02/23/2010 |
| 7652046 | Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase I The present invention comprises methods for the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders through the administration of compounds of formula (I) and formula (II) ... | 01/26/2010 |
| 7642275 | Histone deacetylase inhibitors Compounds, pharmaceutical compositions, kits and methods are provided for use with histone deacetylases (HDACs) that comprise a compound of the formulae: wherein the variables are as defined herein. ... | 01/05/2010 |
| 7642274 | Inhibitor of pain threshold decrease The invention aims to provide a drug having an activity on inhibiting a decrease in pain threshold. Since a κ-opioid receptor agonist effectively inhibits the decrease in pain threshold, it is useful as an inhibitor of pain threshold decrease. ... | 01/05/2010 |
| 7638542 | Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7-tetrahydro-benzothiazoles A process for preparing 2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzothiazoles of formula (I) wherein the asterisk (*) represents an asymmetric carbon and R1 is C1-C6 alkyl; and enantiomers ... | 12/29/2009 |
| 7601745 | Heterocyclic NF-kB inhibitors The present invention relates to compounds of the general formula (III) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof, ... | 10/13/2009 |
| 7576110 | Benzothiazole cyclobutyl amine derivatives Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands... | 08/18/2009 |
| 7524876 | Luciferin derivatives A compound represented by the following general formula (I) or a salt thereof: [wherein R1 and R2 represent hydrogen atom, a C1-6 alkyl group, or a group represented... | 04/28/2009 |
| 7514460 | Benzazole analogues and uses thereof The present invention relates to N2-heteroaryl-benzazole-2,(5 or 6)-diamine derivatives and compositions thereof as protein kinase inhibitors for the treatment of e.g. cancer. ... | 04/07/2009 |
| 7495021 | Benzothiazole- and benzooxazole-4,7-dione, derivatives and their use as cdc25 phosphate inhibitors The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in ... | 02/24/2009 |
| 7495020 | 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyper... | 02/24/2009 |
| 7456204 | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to novel cyclohexylglycine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme i... | 11/25/2008 |
| 7446118 | 3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, ... | 11/04/2008 |
