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| Number | Title | Issue Date |
| 8143295 | Compounds having activity in correcting mutant-CFTR processing and uses thereof The invention provides compositions, pharmaceutical preparations and methods for correcting cellular processing (e.g., folding, trafficking, or post-translational modification) of a mutant-cystic fibrosis transmembrane conductance regulator protein (e.g., ΔF508 CFT... | 03/27/2012 |
| 8129418 | Macrocyclic compounds and methods of treatment The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation. ... | 03/06/2012 |
| 7964623 | Tricyclic benzopyrane compound This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alk... | 06/21/2011 |
| 7932276 | Agent for curing chronic obstructive pulmonary disease The present invention provides a useful and highly safe agent for the treatment of chronic obstructive pulmonary disease, which contains, as the effective ingredient, at least one compound selected from the group consisting of thiazole derivatives and salts thereof ... | 04/26/2011 |
| 7879887 | α-amino acid derivatives and medicaments containing the same as an active ingredient The present invention provides novel α-amino acid derivatives of formula (1): (wherein, R1, R2, R3, R4, X and Y are as defined in the claims) or pharmaceutically acceptable salts... | 02/01/2011 |
| 7772260 | Imidazo[2,1-]-1,3,4-thiadiazole sulfonamides This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I: ... | 08/10/2010 |
| 7741349 | Imidazo[2, 1-b]-1,3,4-thiadiazole sulfonamides This invention relates to compounds of Formula I and the use of compounds of Formula I as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. Formula I: ... | 06/22/2010 |
| 7691888 | Thiazolyl-dihydro-indazole The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized ... | 04/06/2010 |
| 7671077 | Neuroprotective small organic molecules, compositions and uses related thereto The present application is directed to therapeutic compounds, compositions, and methods for culturing neuronal cells and for preventing and the treatment of neurodegenerative diseases, such as Parkinson's disease and amyotrophic lateral sclerosis (ALS). ... | 03/02/2010 |
| 7618989 | Tricyclic oxazolidone derivatives useful as PR modulators Compounds of the following structure are described: wherein R1-R6, R16, m, V, W, X, Y, and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug ther... | 11/17/2009 |
| 7582665 | Compounds exhibiting thrombopoietin receptor agonism Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism: X1—Y... | 09/01/2009 |
| 7538129 | Diazonamide A analog A specific diazonamide A analog and its salts and conjugates are effective in treating proliferative diseases. ... | 05/26/2009 |
| 7517895 | Synthetic diazonamides The application discloses novel synthetic compounds, modeled after unique toxins extracted from the marine invertebrate Diazona angulata useful in the treatment abnormal cell mitosis. The application also discloses novel methods for synthesis of these compoun... | 04/14/2009 |
| 7485655 | 2-Aminothiazole allosteric enhancers of Aadenosine receptors The present invention relates generally to a class of 2-aminothiazole derivatives which have recently been identified as allosteric enhancers of the A1? adenosine receptor. These compounds, and therapeutic compositions containing them, are useful for treating condit... | 02/03/2009 |
| 7470714 | GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent An antitumor effect enhancer for enhancing the antitumor effects of an antitumor substance, which comprises a compound represented by the following formula (1): wherein each R independently represents a hydrogen atom, a low... | 12/30/2008 |
| 7407977 | Substituted N-acyl-2-aminothiazoles There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea. ... | 08/05/2008 |
| 7390908 | Compounds effecting glucokinase The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R1, R2, R3, n and m are as described in the specification, in the preparation of a medicament for the treatment or preventio... | 06/24/2008 |
| 7358214 | Pyrazolyl carboxanilides for controlling unwanted microorganisms This invention relates to novel pyrazolylcarboxanilides of the formula (I) in which R1, G and n are as defined in the disclosure, to a plurality of processes for preparin... | 04/15/2008 |
| 7345178 | Sirtuin modulating compounds Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, dis... | 03/18/2008 |
| 7326403 | Radioactive iodine-labeled compound A radioactive iodine-labeled compound represented by the following formula (I): wherein X represents a radioactive iodine atom which may substitute at an arbitrary position on the benzene ring (preferably 12... | 02/05/2008 |
| 7319096 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders II This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism... | 01/15/2008 |
| 7312200 | 9-ketospinosyn derivatives The present invention relates to derivatives of 9-keto spinosyns, which are substituted by a ═N—(O, NH or NRx)—Ry moiety in the C-9 position, to methods for their manufacture, and to their use for controlling animal pests. ... | 12/25/2007 |
| 7312237 | Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases Compositions and methods are disclosed which are useful of the treatment and prevention of proliferative disorders. ... | 12/25/2007 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7304206 | Plants transformed with polynucleotides encoding broad-spectrum delta-endotoxins Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity and broader insect host range against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments enco... | 12/04/2007 |
| 7300949 | Thiazolopyrazoles and methods of their use This invention concerns novel thiazolopyrazole compounds and compositions comprising them. Methods of using these compounds for the treatment, prevention and management of various diseases and disorders are also encompassed by the invention. ... | 11/27/2007 |
| 7294641 | Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or salt thereof: in... | 11/13/2007 |
| 7250429 | Aminomethyl-substituted thiazolobenzimidazole compounds This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate recepto... | 07/31/2007 |
| 7250501 | Hybrid Cry1A/Cry1F DNA and plants and host cells transformed with same Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Met... | 07/31/2007 |
| 7247635 | Pyrazole derivative Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-dependent calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-dependent calcium channel inhibitors conta... | 07/24/2007 |
| 7241755 | Epothilone derivatives The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1–R7 are as defined herein,... | 07/10/2007 |
| 7238711 | Compounds and methods to inhibit or augment an inflammatory response Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided. ... | 07/03/2007 |
| 7230019 | Imidazo [2,1-b]-1,3,4-thiadiazole sulfonamides This invention relates to compounds of Formula (I) and the use of compounds of Formula (I) as neuroprotective agents in the treatment of neuronal disorders of the central and peripheral nervous systems. ... | 06/12/2007 |
| 7230116 | Pyrazolyl-substituted heterocycles and their use as phytosanitary products The present invention relates to novel pyrazolyl-substituted heterocycles of the formula (I) in which X, Y, Z and Het are as defined in the disclosure, to processes for t... | 06/12/2007 |
| 7227043 | 2-phenyl-2-substituted-1,3-diketones The invention relates to novel phenyl-substituted cyclopentane- and cyclohexane-1,3-dione derivatives of the formula (I) in which W, X, Y, Z, A, B, Q1, Q2, Q3 | 06/05/2007 |
| 7208169 | Biphenyl carboxamides The invention relates to novel biphenylcarboxamides of the formula (I) in which R1, R2, m, n, R3, Y and A are as defined in the disclosure, to a plurality... | 04/24/2007 |
| 7196108 | Bicyclic heterocycles for the treatment of diabetes and other diseases The invention relates to certain bicyclic heterocycles havng the structure shown below which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, and atherosclerosis. | 03/27/2007 |
| 7186893 | Plants transformed with CryET29-encoding nucleic acids Disclosed are transgenic plants, seeds, and progeny from such plants comprising a cryET29 DNA segment. The cryET29 DNA segment encodes CryET29 crystal protein which comprises SEQ ID NO:2 and exhibits insecticidal activity against siphonapteran insects, including lar... | 03/06/2007 |
| 7183238 | [1,2]-oxazine-3,5-diones The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a pl... | 02/27/2007 |
| 7183311 | NF-κB inhibitors The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In yso doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in... | 02/27/2007 |
