Class 514/364 - Oxadiazoles (including hydrogenated)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the hetero ring contains one ring
No. of patents: 740
Last issue date: 04/24/2012

«First «Previous1 2 3 4 5 6 7 8 9 10 11 Next»Last»

Number	Title	Issue Date
8163782	1,2,4-oxadiazole benzoic acid compositions Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of prematu...	04/24/2012
8133910	Thiophene derivatives as S1P1/EDGE1 receptor agonists The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. ...	03/13/2012
8101641	Hydroxylated 1,2,4-oxadiazole benzoic acid compounds and compositions thereof Novel hydroxylated 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising a hydroxylated 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated...	01/24/2012
8093276	Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production The present invention provides a method for the treatment of head trauma, traumatic brain injury, and/or dementia pugilistica comprising administering a therapeutically effective amount of (2R)-2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]m...	01/10/2012
8088803	1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such...	01/03/2012
8084477	Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production The present invention provides a novel alpha-(N-sulfonamido)acetamide compound, its pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease and other conditions associated with β-amyloid peptide. ...	12/27/2011
8084478	Substituted 5- phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase Compounds of formula (I), or salts thereof, which inhibit acetyl CoA (acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, wherein R1, R2 and R3 are each independ...	12/27/2011
8071632	Antioxidant inflammation modulators: novel derivatives of oleanolic acid Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, ...	12/06/2011
8067448	Selective androgen receptor modulators This invention provides compounds of formulas I, Ia, Ib, Ic, Id, Ie, and or salts thereof, pharmaceutical compositions comprising a compound of formulas I, Ia, Ib, Ic, Id, Ie, and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, ...	11/29/2011
8044077	Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production The present disclosure provides novel deuterated alpha-(N-sulfonamido)acetamide compounds, their pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease, head trauma, traumatic brain injury, and/or dementia pugilistica and...	10/25/2011
8044076	Phenyl derivatives and their use as immunomodulators The invention relates to phenyl derivatives of formula (I), their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. ...	10/25/2011
8017636	1,2,4-Oxadiazole benzoic acid compositions and their use in bioassays Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of prematu...	09/13/2011
8013003	Di-substituted amides for enhancing glutamatergic synaptic responses This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behavio...	09/06/2011
8003676	1,3,4-oxadiazole derivatives as DGAT1 inhibitors Compounds of formula (I), or salts thereof, which inhibit acetyl CoA (acetyl coenzyme A):diacylglycerol acyltransferase (DGAT1) activity are provided, wherein: n is 1, 2 or 3 and each R is independently selecte...	08/23/2011
7998988	Biphenyl compounds useful in the treatment or prevention of cardiovascular disorders The invention relates to biphenyl compounds of formula (I): wherein U, V and W together form a group of the formula *—CH═CH—CH	08/16/2011
7985761	Diphenylurea derivatives and their use as chloride channel blockers or BKchannel modulators The present invention relates to novel diphenylurea derivatives useful as chloride channel blockers or BKCa channel modulators. In other aspects the invention relates to the use of these compounds in a method for therapy, and to pharmaceutical comp...	07/26/2011
7981910	Triazole derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dysli...	07/19/2011
7977362	Alpha-(N-benzenesulfonamido)cycloalkyl derivatives Disclosed are compounds, pharmaceutical compositions containing the compounds, methods for using the compounds and processes for making the compounds. More specifically, the disclosure relates to alpha-(N-benzenesulfonamido)cycloalkyl compounds that may inhibit one ...	07/12/2011
7956074	Aryl-isoxazolo-4-yl-oxadiazole derivatives The present invention is concerned with isoxazol-4-yl-oxadiazole derivatives of formula wherein R1, R2, and R3, are as defined in the specification and...	06/07/2011
7943645	Piperidine compounds for use as orexin receptor antagonist This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists. ...	05/17/2011
7939494	Method for administering GLP-1 molecules The invention relates to formulations that demonstrate the feasibility of oral absorption comprising glucose-like peptide-1 compounds and specified delivery agents, and to methods of stimulating GLP-1 receptor in a subject in need of such stimulation, by administrat...	05/10/2011
7923462	Catechol derivative, pharmaceutical composition containing the same, use of the catechol derivative, and use of the pharmaceutical composition The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the lik...	04/12/2011
7915298	Compounds and methods for leukotriene biosynthesis inhibition This invention provides novel salt and crystalline forms thereof of (−)4-(4-fluorophenyl)-7-[({5-[1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl}amino)-methyl]-2H-chromen-2-one. The compounds are 5-LO inhibitors and are useful for treatment of condition...	03/29/2011
7910613	2-acylaminothiazole derivatives The Invention relates to compounds of the formula I, wherein the variables are as defined in the claims, for use as a medicament. The compounds are A2A-receptor legends and are useful in the treatment of neurological and psychiatric disorders where an A	03/22/2011
7902235	Compounds for nonsense suppression, and methods for their use The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention ...	03/08/2011
7875637	Benzimidazole derivative and use as a II receptor antagonist The present invention relates to a compound represented by the formula (I) wherein R1 is a group represented by the formula wherein R2, R3, R...	01/25/2011
7872032	1, 3, 4-oxadiazol-2-ones as PPAR delta modulators and their use thereof The present invention is directed to 1,3,4-oxadiazalones, compounds of formula I and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein.	01/18/2011
7863302	Compounds and methods for modulating FX-receptors Compounds of formula and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases. ...	01/04/2011
7858649	Imidazole derivatives and their use for modulating the GABAreceptor complex This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are of the general formula (I) and include any of its stereoisomers, any mixture of its ...	12/28/2010
7855220	Bicyclic derivatives as modulators of voltage gated ion channels Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions. ...	12/21/2010
7851492	ERG channel openers for the treatment of cardiac arrhythmias This invention relates to the use of ERG channel openers for the treatment of cardiac arrhythmias, and to the use of specific compounds for such treatment. In a separate aspect the invention provides novel compounds useful as ERG channel openers. ...	12/14/2010
7851493	Phenyl-1,2,4-oxadiazolone derivatives with phenyl group, processes for their preparation and their use as pharmaceuticals The invention relates to phenyl-1,2,4-oxadiazolone derivatives with phenyl group and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist activity. What are described are compounds of the formula I,	12/14/2010
7846950	Histamine H3 receptor inhibitors, preparation and therapeutic uses The present invention provides novel compounds with histamine-H3 receptor antagonist or inverse agonist activity. In particular, the invention provides a compound of Formula I, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the...	12/07/2010
7834039	Oxadiazole compounds Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P famil...	11/16/2010
7812040	Histamine-3 receptor antagonists This invention is directed to a compound of the formula Ia or Ib, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated ...	10/12/2010
7799812	Reverse isoxazoles The present invention relates to polycyclic compounds, processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them. ...	09/21/2010
7799811	Agent for prevention and treatment of cancer comprising oxadiazole urea compound obstructing activity of stat Disclosed herein is an agent for preventing and treating cancer which includes an oxadiazole urea compound represented by Chemical Formula 1, below, as an effective ingredient. The oxadiazole urea compound effectively inhibits the growth of cancer cell lines and the...	09/21/2010
7795283	Oxadiazole derivative as DGAT inhibitors Compounds of formula (I), and salts and pro-drugs thereof: Formula (I) wherein for example R1 is optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a direct bond, and a (substituted) alkyl chain; R2 is a...	09/14/2010
7772259	1,2,4-Oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of prematu...	08/10/2010
7759372	Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula:	07/20/2010

«First «Previous1 2 3 4 5 6 7 8 9 10 11 Next»Last»

PatentStorm

Quotables

PatentStorm News

Class 514/364 - Oxadiazoles (including hydrogenated)