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| Number | Title | Issue Date |
| 8153667 | Tricyclic aromatic and bis-phenyl sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith. ... | 04/10/2012 |
| 8110589 | Ectoparasiticide composition and a method for exterminating extoparasites An ectoparasiticide composition for animals including etoxazole as an active ingredient, a UV absorber and a phenol antioxidant, and a method for exterminating ectoparasites using the composition. The preferable blending ratio between etoxazole, a UV absorber and a ... | 02/07/2012 |
| 8022032 | Method for customized dispensing of variable dose drug combination products for individualizing of therapies The method set out herein involves identifying the concentration of each of two or more active therapeutics tailored to treat a particular patient's unique metabolism and one or more diseases, communicating that information to a producer who has multiple fixed or va... | 09/20/2011 |
| 8003674 | Flavivirus inhibition by sultams and related compounds Disclosed herein are compounds, compositions and methods for treating or ameliorating flavivirus infections. This is particularly important because the present disclosure provides methods for treating flavivirus infections for which there is no effective vaccine. | 08/23/2011 |
| 7411064 | 1-Heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor ... | 08/12/2008 |
| 7407987 | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. ... | 08/05/2008 |
| 7388029 | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. ... | 06/17/2008 |
| 7361767 | N-sulfonyldicarboximide containing tethering compounds Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The s... | 04/22/2008 |
| 7361687 | Arylsulphonamide derivatives and methods of preparing The present invention relates to novel arylsulphonamide compounds, defined by formula I and the description, as well as their method of preparation and their therapeutic use ... | 04/22/2008 |
| 7348017 | Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin A dithiazole compound or a salt thereof is disclosed. The compound inhibits matrix metalloprotease (MMPs) activity and can be used in pharmaceutical and cosmetic compositions for the treatment of skin conditions. ... | 03/25/2008 |
| 7329761 | Substituted imides Novel imides are inhibitors of tumor necrosis factor alpha and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is (R)-2-Phthalimido-3-(3′,4′-dimethoxyphenyl)propane | 02/12/2008 |
| 7259179 | Kinase inhibitors A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated disease states usin... | 08/21/2007 |
| 7223780 | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their us... | 05/29/2007 |
| 7214701 | Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ... | 05/08/2007 |
| 7211592 | Substituted an unsubstituted benzooxathiazoles and compounds derived therefrom The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in medicaments. ... | 05/01/2007 |
| 7192940 | Ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 03/20/2007 |
| 7179833 | Method of synthesising perindopril and the pharmaceutically acceptable salts thereof Process for the synthesis of perindopril of formula (I): and its pharmaceutically acceptable salts. ... | 02/20/2007 |
| 7172757 | Method of treating fibroproliferative disorders Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with ... | 02/06/2007 |
| 7163954 | Substituted naphthyl benzothiophene acids The present invention relates generally to substituted naphthyl benzothiophene acids and methods of using them. ... | 01/16/2007 |
| 7147852 | Methods for reducing TGF-β production and for promoting repair of liver damage Materials and methods for reducing TGF-β production and promoting repair of liver damage in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of an anti-zvegf3 antibody in combination ... | 12/12/2006 |
| 7129256 | Antiparkinsonism drugs A compound represented by the formula: wherein A is thiazolyl or the like, X is a bond or the like, m is an integer of 0 to 4, Y is optionally substituted alkyl or the like, Z is a substituent represented by the ... | 10/31/2006 |
| 7129257 | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed. ... | 10/31/2006 |
| 7105556 | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2 | 09/12/2006 |
| 7094550 | Method to determine TGF-beta A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): wherein Z is C═O or a covalent bond; Y is H or O(C1–C4)alkyl, R1 | 08/22/2006 |
| 7087621 | Benzo- and azabenzodithiazole compounds The present invention provides compounds of formula I or a pharmaceutically acceptable salt, solvate, prodrug or isomer thereof and compounds of the formula ... | 08/08/2006 |
| 7057039 | 1-heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 06/06/2006 |
| 6972340 | Selective protein tyrosine phosphatatase inhibitors Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of di... | 12/06/2005 |
| 6958355 | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have... | 10/25/2005 |
| 6951878 | Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases) The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PT... | 10/04/2005 |
| 6936624 | Agents for preserving technical materials against insects The use of the compounds of the formula (I) as agents for preserving technical materials against insects. ... | 08/30/2005 |
| 6927215 | Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (I) The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I) in which X represents hydrogen, halogen or alkyl, m represents integer... | 08/09/2005 |
| 6911459 | Pharmaceutical composition Pharmaceutical composition which comprises an insulin sensitivity enhancer in combination with other antidiabetics differing from the enhancer in the mechanism of action, which shows a potent depressive effect on diabetic hyperglycemia and is useful for prophylaxis ... | 06/28/2005 |
| 6864276 | Active substance combinations having insecticidal and acaricidal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G ... | 03/08/2005 |
| 6841536 | Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof Disclosed is a prodrug of the formula: where A is a sulfur or a selenium, and R is derived from a mono- di- or oligo- saccharide. Also disclosed is a prodrug of the formula: | 01/11/2005 |
| 6838439 | Heterocytes as inhibitors of leucocyte adhesion and as VLA-4 antagonists The present invention relates to compounds of the formula I which are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. Th... | 01/04/2005 |
| 6803379 | PHARMACOLOGICAL AGENTS AND METHODS OF TREATMENT THAT INACTIVATE PATHOGENIC PROKARYOTIC AND EUKARYOTIC CELLS AND VIRUSES BY ATTACKING HIGHLY CONSERVED DOMAINS IN STRUCTURAL METALLOPROTEIN AND METALLOENZYME TARGETS The invention relates to the treatment of viral, bacterial, parasitic, proliferative diseases, neurodegenerative diseases, inflammatory diseases, immunological diseases, transplanted organ rejection, and diseases produced by intoxication with heavy metals. The inven... | 10/12/2004 |
| 6780881 | Freeze-dried pantoprazole preparation and pantoprazole injection Lyophilized pantoprazole preparations which are obtainable by freeze-drying of an aqueous solution of pantoprazole, ethylenediamine tetraacetic acid and/or a suitable salt thereof, and sodium hydroxide and/or sodium carbonate are disclosed. The preparations have adv... | 08/24/2004 |
| 6777405 | Detection and treatment of duplex polynucleotide damage Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are tre... | 08/17/2004 |
| 6770642 | Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 08/03/2004 |
| 6743817 | Substituted fused pyrroleimines and pyrazoleimines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists... | 06/01/2004 |
