Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8178501 | Antibiotic combinations for providing total solution to the treatment of infections The invention relates to a new pharmaceutical composition, a method of treatment of infection and also a process to prepare the composition. The infectious complications are important causes of morbidity and mortality. Hospital acquired pneumonia (HAP) remains the m... | 05/15/2012 |
| 7915229 | Compositions containing piperacillin and tazobactam useful for injection An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and option... | 03/29/2011 |
| 7498312 | Compositions containing piperacillin and tazobactam useful for injection An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and option... | 03/03/2009 |
| 7371733 | Anti bacterial compounds The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are of the general formula ... | 05/13/2008 |
| 7345024 | Pharmaceutical preparation, method for its production as well as its use The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have as their cationic component one of the antibiotics gentamicin, clinda... | 03/18/2008 |
| 7282487 | Method for treating bacterial infections in horses or pigs with tilmicosin The invention relates to methods of treating a bacterial infection in a horse or a pig. The method involves administering to the horse or pig a composition comprising (i) a salt made from tilmicosin and a lipophilic acid and (ii) a pharmaceutically acceptable solven... | 10/16/2007 |
| 7244712 | Aminoglycoside antibiotics and methods of using same The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses antibiotic activity and are not susceptible to development of resistant... | 07/17/2007 |
| 7241746 | Method and composition for treating periodontal disease The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is selected from the group consisting of doxycycline, gentamicin, tobramici... | 07/10/2007 |
| 7220727 | Aminoglycosides as antibiotics The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human). ... | 05/22/2007 |
| 7124634 | Single plate capacitive acceleration derivative detector A capacitance accelerometer includes a housing, and a plate fixed within the housing. A moveable plate is disposed in substantially parallel relation to the fixed plate and is coupled to the housing along at least an edge. The moveable plate and the fixed plate defi... | 10/24/2006 |
| 6987094 | Optimized formulation of tobramycin for aerosolization The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room temperature. Said formulation can be advantageously used for the treatmen... | 01/17/2006 |
| 6946137 | Methods for the controlled delivery of pharmacologically active compounds The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmac... | 09/20/2005 |
| 6900184 | Compositions containing pipercillin and tazobactam useful for injection The invention pertains to pharmaceutical compositions of Zosyn® piperacillin with tazobactam in the presence of a buffer, preferably citrate, a particulate formation inhibitor, preferably EDTA optionally an aminoglycoside which when frozen and thawed or lyophilized... | 05/31/2005 |
| 6858589 | Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and an aminoglycoside to attain a peak concentration of at least 4 mg/l of... | 02/22/2005 |
| 6818625 | Method for increasing survival rate of cells in animal cell culture under hypoxia condition The present invention relates to a method for increasing survival rate of cells in animal cell culture under hypoxia condition by adding antibiotics to the culture media. The method of present invention comprises a step of culturing animal cells in culture media con... | 11/16/2004 |
| 6716822 | Therapeutic agent for ischemia which inhibits apoptosis under ischemic condition The present invention relates to a therapeutic agent for ischemia which inhibits apoptosis under ischemic condition. The therapeutic agent of the present invention comprises antibacterial agents of quinolones, quinones, aminoglycosides or chloramphenicol as an activ... | 04/06/2004 |
| 6706290 | Methods for eradication of nanobacteria Nanobacteria contribute to pathological calcification in the human and animal body, including diseases such as kidney stones, salivary gland stones, dental pulp stones and atherosclerosis. The present invention provides methods for sterilizing articles contaminated ... | 03/16/2004 |
| 6630135 | Use of sustained release antibiotic compositions in ophthalmic surgical procedures An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions wh... | 10/07/2003 |
| 6541456 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the ... | 04/01/2003 |
| 6475993 | Treatment of hereditary diseases with gentamicin This invention relates to a method of treating an inherited disease due to a point mutation producing a stop codon by administering an effective dose of an aminoglycoside antibiotic or a derivative thereof. Mdx mouse, which is an animal model for Duchenne... | 11/05/2002 |
| 6475992 | Methods of and compositions for potentiating the action of agents active on cell wall sites of the susceptible bacteria The invention provides a method of potentiating the activity of antibacterial agents that act on bacterial cell walls, comprising the step of administering to a subject an antibacterial agent and an aminoglycoside to attain a peak concentration of at leas... | 11/05/2002 |
| 6379882 | Method for selecting compounds for treating ischemia-related cellular damage A method of screening for and treating subjects with a therapeutically effective amount of a compound that is effective in reducing cellular damage related to an ischemic condition, such as stroke or glaucoma. Test compounds are selected and therapeutical... | 04/30/2002 |
| 6265386 | Therapeutic use of D-methionine to reduce the toxicity of ototoxic drugs, noise, and radiation Methods of preventing or reducing hearing or balance loss, damage to ear cells, weight loss, gastrointestinal toxicity, neurotoxicity, alopecia, and prolonging survival in patients undergoing treatment with therapeutically effective amounts of platinum-co... | 07/24/2001 |
| 5998464 | 4-Oxa and 4-thia steroids The compounds of the present invention are those of structural formula (I) ##STR1## wherein X is oxygen or sulfur. Pharmaceutical compositions and methods of use of the compounds in the treatment of hyperandrogenic conditions are disclosed. In additi... | 12/07/1999 |
| 5942547 | 2-Deoxystreptamine derivatives, pharmaceutical compositions thereof and therapeutic methods using same This invention provides a compound having the formula: ##STR1## wherein R1 and R3 independently are hydrogen, --CHO, --COCH3, --COR7, --A--Ar--(Q)z, etc.; wherein D is a C1-6 linear, C... | 08/24/1999 |
| 5900406 | Use of antibiotics of the type 2-deoxystreptamine substituted with aminosugars to inhibit growth of microorganisms containing group I introns The invention described herein provides for methods of screening for compounds that can be used to prevent or inhibit the growth of microbial eukaryotes, particularly plant or animal pathogens. The screening methods of the invention involve the step of sc... | 05/04/1999 |
| 5677288 | Use of aminoglycosides to protect against excitotoxic neuron damage A method is disclosed for reducing excitotoxic damage to neurons, which can occur as a result of stroke, cardiac arrest, or other events or conditions. This method involves administering an aminoglycoside that suppresses the flow of calcium ions into neur... | 10/14/1997 |
| 5662929 | Therapeutic liposomal formulation The invention relates to a liposomal formulation containing a therapeutic agent. The formulation of the invention when administered to animals, allows a substantial increase in antibacterial activity of the agent, through an enhanced penetration of the ag... | 09/02/1997 |
| 5595977 | Salts of amino glycosides The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid of formula I: ([sucrose-octa-O-sulfonic acid8- ]-[R-(NH3+)x ]y -Mzn+) ... | 01/21/1997 |
| 5534408 | 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule which binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are the 2-deoxystr... | 07/09/1996 |
| 5527781 | 4-O-(aminoglycosyl)- or 4,6-di-O-(aminoglycosyl)-2,5-dideoxy-5,5-difluorostreptamine derivatives As new compounds are now synthetized 5-deoxy-5,5-difluoro derivatives of aminoglycosidic antibiotics of neamine, kanamycin A-series, kanamycin B-series, gentamicin-series and seldomycin-series. Further, the 1-N-(-hydroxy-ω-aminoalkanoyl) derivativ... | 06/18/1996 |
| 5217707 | Pharmaceutical composition and process for the preparation thereof The invention relates to a stabile, aqueous suspoemulsion containing as active ingredient 0.2-5 weight % of primycin, 5-25 weight % of propylene glycol, 0.5-5 weight % of non-ionic surface active agent, if desired 15 weight % of auxiliary agent and distil... | 06/08/1993 |
| 4877775 | Polymeric aminosaccharides as antihypercholesterolemic agents Crosslinked copolymers of monomeric aminosaccharides such as aminoglycosidic antibiotics, e.g. neomycin, or of polymeric aminosaccharides, e.g., chitosan, with dialdehydes are useful antihypercholesterolemic agents due to their ability to bind with bile ... | 10/31/1989 |
| 4795743 | 2'-deamino-2'-hydroxyistamycin Bo derivatives of low toxicity As new 2'-deamino-2'-hydroxyistamycin Bo derivatives are provided four compounds, namely 2'-deamino-2'-hydroxyistamycin B; 2'-deamino-2'-hydroxy-3-O-demethylistamycin B; 4-N-(ଲ-alanyl)-2'-deamino-2'-hydroxyistamycin Bo ; and ... | 01/03/1989 |
| 4781920 | Anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole The invention provides physically stable anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole and other anthelmintic compounds in combination with a wide variety of therapeutic agents such as an... | 11/01/1988 |
| 4749694 | Novel lysine esters used as absorption Novel lysine esters used as absorption enhancing agents for gastrointestinally and rectally administered drugs. Also provided are processes for preparation of said lysine ester compounds as well as pharmaceutical formulations and methods for their use as ... | 06/07/1988 |
| 4746516 | Pharmaceutical compositions consisting or consisting essentially of freeze-dried drug-carrying liposomes A method is disclosed for purifying non-homogeneous systems, known as liposomic suspensions, from non-entrapped drugs wherein said suspensions are treated with liquid or solid polymers of synthetic and organic nature having chemical functionality, which a... | 05/24/1988 |
| 4650790 | Drug combinations having synergistic effect The invention relates to a synergistic antibiotic composition useful for the treatment of respiratory, gastrointestinal or urinary infections and septicaemia of domestic animals. The composition comprises tiamulin hydrogen fumarate and an aminoglycoside a... | 03/17/1987 |
| 4645760 | Activated aminoglycosides and aminoglycoside-aminocyclitols pharmaceutical compositions and method of use Aminoglycosides and aminoglycoside-aminocyclitols which have been oxygen-radical activated show a broad spectrum of antibacterial activity. The activated compounds are able to penetrate the cell membranes of bacteria and show substantially enhanced activi... | 02/24/1987 |
| 4567165 | N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B As new semi-synthetic antibiotic derivatives are provided N-methanesulfonic acid derivatives of 3-demethoxyistamycin B which are less toxic than the parent 3-demethoxyistamycin B but retain usefully high antibacterial activity of the parent antibiotic. Th... | 01/28/1986 |
