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| Number | Title | Issue Date |
| 8124631 | Use of quaternary pyridinium salts as vasoprotective agents The invention is directed to a method for enhancing prostacyclin levels in a mammal in need thereof, wherein the method includes administering a quaternary pyridinium salt of formula (I), wherein R is NH2, CH | 02/28/2012 |
| 7935717 | Method for treating hypertriglyceridemia, dyslipidemia and hypercholesterolemia with a 1-methylnicotinamide salt The invention is directed to a method for treating hypertriglyceridemia, dyslipidemia and hypercholesterolemia by administration of a 1-methylnicotinamide salt. ... | 05/03/2011 |
| 7893095 | Use of quaternary pyridinium compounds for vasoprotection and/or hepatoprotection The invention relates to a method for the treatment or prevention of diseases or conditions associated with vascular endothelium dysfunction or liver injury comprising the administration to a patient in a need of such treatment or prevention of a therapeutically or ... | 02/22/2011 |
| 7893094 | Amphiphilic pyridinium compounds, method of making and use thereof The present invention is directed to the amphiphilic pyridinium compounds, such as for suppressing IL-8 secretion and production. The present invention further provides methods of making and using such compounds for the treatment of the IL-8 related diseases, such a... | 02/22/2011 |
| 7550491 | Ionic liquids having [N(CF)]anions The present invention relates to salts comprising bis(trifluoromethyl)imide anions and saturated, partially or fully unsaturated, heterocyclic cations, to a process for the preparation thereof, and to the use thereof as ionic liquids. ... | 06/23/2009 |
| 7335653 | Bis-aryl sulfonamides Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls i... | 02/26/2008 |
| 7300948 | Alkynyl compounds as non nucleoside reverse transcriptase inhibitors Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formula wherein the substituents are as defined in the following table ... | 11/27/2007 |
| 7285556 | Thienopyrimidine-based inhibitors of the src family Various thienopyrimidine-based analog compounds are able to selectively inhibit the Src family of tyrosine kinases. Compounds of the present invention, capable of such selective inhibition, are of the basic structure seen in formulae (I), (II) or (III): | 10/23/2007 |
| 7250428 | Cetylpyridinium salt of an anti-inflammatory agent and pharmaceutical compositions containing it Cetylpyridinium salt of diclofenac. ... | 07/31/2007 |
| 7235576 | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy. ... | 06/26/2007 |
| 7189383 | Radioactively labelled amino acid analogues, their preparation and use The present invention relates to Halogenated amino acid analogues for use in diagnosis, which compounds have the general formula (I) wherein: R is (C1–C6) alkyl optionally substituted with thioether or ether oxygen atom when n=0, or a substit... | 03/13/2007 |
| 7141590 | Pharmaceutical uses and synthesis of nicotinanilide-N-oxides Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies. ... | 11/28/2006 |
| 7098201 | Heteroaromatic derivatives having an inhibitory activity against HIV integrase A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORA wherein RA is hydrogen or ester residue, —CONRBRC wher... | 08/29/2006 |
| 7064139 | Method for treating retroviral infections Compositions and methods of treating a retroviral infection in an afflicted host and/or inhibiting replication of a retrovirus involve administering a therapeutically effective amount of the following compound of formula I: A-L-B (I) wherein... | 06/20/2006 |
| 7045538 | Compounds capable of activating cholinergic receptors The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via admini... | 05/16/2006 |
| 7015239 | Fungicide for plants A fungicidal composition and method of treating plant diseases using a compound of formula ... | 03/21/2006 |
| 6984645 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein Compounds that are dual aP2/k-FABP inhibitors are provided having the formula wherein A, B, X, Y, R1, R2 and R3 are as described herein. A method is also provided for treating diabetes ... | 01/10/2006 |
| 6979695 | Compounds capable of activating cholinergic receptors The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via admini... | 12/27/2005 |
| 6969521 | Aerosol insect repellent composition having low VOC content and method of applying same to the skin Disclosed is an aerosol insect repellent composition. The composition has (a) an amount of an insect repellent effective to repel insects when applied to the skin and (b) a cosmetically-acceptable vehicle in which to disperse and deliver the insect repellent active.... | 11/29/2005 |
| 6958399 | Compounds capable of activating cholinergic receptors Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5... | 10/25/2005 |
| 6953811 | N-substituted tetrahydropyridines and their use as pesticides A description is given of compounds of the formula in which R1 and R2 independently of one another are halogen, C1-C6alkyl, halo-C1-C6alkyl... | 10/11/2005 |
| 6953814 | Natural insect repellant A topical insect repellent with extended duration of protection was obtained from mixtures of molecules based on two or more volatile repellent organic molecular species occurring naturally on the human skin surface. The novel repellent comprises mixtures of lower, ... | 10/11/2005 |
| 6939885 | Aryl sulfonamides Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful... | 09/06/2005 |
| 6903118 | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides The invention relates to new piperazinyl-substituted pyridylalkane, alkene, and alkine acid amides substituted with saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group according to the general formula (I) as well as methods ... | 06/07/2005 |
| 6878730 | Quaternary ammonium compounds The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious rhinitis. ... | 04/12/2005 |
| 6864276 | Active substance combinations having insecticidal and acaricidal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G ... | 03/08/2005 |
| 6864269 | Concentrated, non-foaming solution of quarternary ammonium compounds and methods of use A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an alcohol, is disclosed. A diluted QAC solution is used to contact food produ... | 03/08/2005 |
| 6858623 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are... | 02/22/2005 |
| 6815458 | Azacyclic compounds Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment. ... | 11/09/2004 |
| 6784194 | Therapeutic use of a thienylcyclohexylamine derivative A method of inhibiting effects of exogenous neurotoxic or neurotoxinic products in warm-blooded animals comprising administering to warm-blooded animals before exposure to said products an inhibitorily effective amount of reversible cholinesterase inhibitor selected... | 08/31/2004 |
| 6756393 | Azacyclic compounds Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In the method, an effective amount of a compound is adminstered to a patient in need of such treatment. ... | 06/29/2004 |
| 6727237 | Inhibitors of bacterial NAD synthetase The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme. ... | 04/27/2004 |
| 6726894 | Transport vehicles for macromolecules The invention relates to new compounds with the general formula I for use as a tool to introduce macromolecules into cells. The invention further relates to compositions for introducing macromolecules into cells, comprising vesicles formed by at least one compound i... | 04/27/2004 |
| 6706741 | Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts The present invention provides an excellent acetylcholinesterase inhibitor. That is, it provides an acetylcholinesterase inhibitor comprising a 1-benzylpyridinium salt represented by the following formula: wherein R... | 03/16/2004 |
| 6686358 | Bicyclic amino-pyrazinone compounds A compound of formula (I): ##STR1## wherein: R1 represents hydrogen, or linear or branched (C1 -C6)alkyl optionally substituted by one or more identical or different groups selected from aryl, heteroaryl, cycloalkyl and he... | 02/03/2004 |
| 6677361 | Topical formulations for the transdermal delivery of niacin and methods of treating hyperlipidemia Niacin and niacin prodrugs are topically administered as suitable formulations to device for impoving the lipid profiles of subjects, preferably humans.... | 01/13/2004 |
| 6664280 | Antivesicant compounds and methods of making and using thereof As disclosed herein, the present invention provides a compound having the structural formula ##STR1## wherein R1, R2, R3, and R4 are each independently H, or a methyl, halo, trifluoromethyl, nitro, alkyloxy, or ... | 12/16/2003 |
| 6649633 | Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes This application is directed to compounds useful as inhibitors at PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis and chronic obstructuive pulmonary disease, of the form... | 11/18/2003 |
| 6638940 | Tetrahydropyridines as pesticides Compounds of formula ##STR1## are described, wherein R1 and R2 are for example, independently of each other, halogen, C1 -C6 -alkyl, C3 -C6 -cycloalkyl, halogen-C1 -C6 | 10/28/2003 |
| 6638946 | Substituted pyridine or piperidine compounds The invention relates to a compound of formula (I): ##STR1## wherein: A represents pyridine, pyridinium or piperidine R1, R2, R3 and R4 are as defined in the description R5 represents hydrogen, a ni... | 10/28/2003 |
