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| Number | Title | Issue Date |
| 8183268 | Heteroaryl (substituted)alkyl -substituted sulfoximines as insecticides N-Substituted heteroaryl (substituted)alkyl sulfoximines are effective at controlling insects. ... | 05/22/2012 |
| 8178565 | Multi-substituted pyridyl sulfoximines and their use as insecticides Multi-substituted pyridyl sulfoximines are useful as insecticides. ... | 05/15/2012 |
| 8178564 | Use of picoplatin to treat colorectal cancer The invention provides a method of treatment of colorectal cancer by administration of the anti-cancer platinum drug picoplatin in conjunction with 5-FU and leucovorin in a variety of treatment regimens. Dosages, dosing schedules, and ancillary treatments are descri... | 05/15/2012 |
| 8173686 | Use of picoplatin to treat colorectal cancer The invention provides a method of treatment of colorectal cancer by administration of the anti-cancer platinum drug picoplatin in conjunction with 5-FU and leucovorin in a variety of treatment regimens. ... | 05/08/2012 |
| 8168660 | Fungicidal composition comprising a pyridylethylbenzamide derivative and a compound capable of inhibiting the ergosterol biosynthesis A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and a compound capable of inhibiting the ergosterol biosynthesis (b) in a (a)/(b) weight ratio of from 0.01 to 20. A composition further comprising an additional f... | 05/01/2012 |
| 8168662 | Use of picoplatin to treat colorectal cancer The invention provides a method of treatment of colorectal cancer by administration of the anti-cancer platinum drug picoplatin in conjunction with 5-FU and leucovorin in a variety of treatment regimens. Dosages, dosing schedules, and ancillary treatments are descri... | 05/01/2012 |
| 8168661 | Use of picoplatin to treat colorectal cancer The invention provides a method of treatment of colorectal cancer by administration of the anti-cancer platinum drug picoplatin in conjunction with 5-FU and leucovorin in a variety of treatment regimens. ... | 05/01/2012 |
| 8133909 | Heteroaromatic monoamides as orexinin receptor antagonists The present invention is concerned with novel sulfonamides of formula wherein R1, R2, R3, R4, R5, Ar, Ar1, Ar2, n, o and p are as described in the... | 03/13/2012 |
| 8119668 | Treatment methods employing histamine Hreceptor antagonists, including betahistine Methods of treating depression, binge eating disorder, narcolepsy, excessive daytime sleepiness, substance use disorders, and Prader Willi syndrome, disorders characterized at least in part by hypocortisolemia and decreased activity of the hypothalamic-pituitary-adr... | 02/21/2012 |
| 8101640 | Antibacterial agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacteria... | 01/24/2012 |
| 8093275 | Oxazolone and pyrrolidinone-substituted pryidine amides as P2Xand P2Xantagonists Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Als... | 01/10/2012 |
| 8080568 | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors This invention relates to 2-pyridyl substituted imidazoles which are inhibitors of the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type I receptor (ALK4), methods for their preparation, and their use in medicine, specifically in ... | 12/20/2011 |
| 8039493 | Biaryl sulfonamide derivatives The invention is concerned with novel biaryl sulfonamide derivatives of formula (I) wherein R1 to R3 and Y are as defined in the description and in the claims, as well as physiologically acceptable sal... | 10/18/2011 |
| 7968574 | Biaryl compositions and methods for modulating a kinase cascade The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt thereof. The compounds of ... | 06/28/2011 |
| 7923461 | TNF-α production inhibitors A compound having the following formula wherein A is —O—; B is alkylene or alkenylene optionally containing —O—, —S—, —(NR7)—, —CO— or —N═; R1 and R2 are alkyl, alken... | 04/12/2011 |
| 7906537 | Substituted p-diaminobenzene derivatives The present invention relates to aniline derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use. ... | 03/15/2011 |
| 7906538 | Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives Novel trifluoromethanesulfonanilide oxime ether compounds useful for controlling endo and/or ectoparasites in the environment are provided, together with methods of making the same, and methods of using the inventive compounds to treat parasite infestations in vivo ... | 03/15/2011 |
| 7902233 | Compounds useful as pesticides Compounds useful to control pests are provided. ... | 03/08/2011 |
| 7893092 | Anthranilamide derivatives as insecticides Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredients and can be prepared ... | 02/22/2011 |
| 7893093 | Sulfonyl containing compounds as cysteine protease inhibitors The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compo... | 02/22/2011 |
| 7888377 | Monocyclic and bicyclic himbacine derivatives useful as thrombin receptor antagonists Monocyclic and bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt or solvate of said compound wherein represents an optional double bond and wherein G | 02/15/2011 |
| 7888376 | Heterocyclic CETP inhibitors Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein. ... | 02/15/2011 |
| 7884116 | Octahydronaphthalene derivative and medicine It is an object of the invention to provide a novel octahydronaphthalene derivative with an activity of inhibiting ICAM-4 expression and a pharmaceutically acceptable salt thereof. The invention encompasses, for example, agents for suppressing ICAM-1, therapeutic ag... | 02/08/2011 |
| 7879885 | Thioalkeneamides as transketolase inhibitors The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined he... | 02/01/2011 |
| 7868027 | Process for the preparation of certain substituted sulfilimines Cyano-substituted sulfilimines are produced efficiently and in high yield from the corresponding sulfides by reaction with cyanamide and hypochlorite. ... | 01/11/2011 |
| 7846949 | Compounds and compositions as LXR modulators The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs). ... | 12/07/2010 |
| 7829587 | Substituted 2-aminotetralin derivatives as selective alpha 2B agonist Substituted 2-aminotetralin derivatives as selective alpha 2B agonists can be incorporated in a pharmaceutical composition and can be used in methods of treating an alpha 2B receptor mediated diseases or conditions. The compounds are represented by Formula 1: | 11/09/2010 |
| 7812039 | Drugs for chronic pains Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A-(B)b0-(C)o0-N02 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R-TI-, wherein R is the radical of an analgesic drug for the chronic pain, in partic... | 10/12/2010 |
| 7790758 | Compounds which potentiate glutamate receptor and uses thereof in medicine This invention relates to potentiation of the glutamate receptor by novel compounds of formula (I): The invention also relates to the use of the derivatives in treating diseases and conditions mediated by potentiation of the ... | 09/07/2010 |
| 7776894 | Compositions and methods for inhibiting growth and metastasis of melanoma There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further pro... | 08/17/2010 |
| 7776895 | Inhalation devices for delivering phenethanolamine derivatives for the treatment of respiratory diseases The invention provides inhalation devices comprising a compound which is 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; or a salt or solvate thereof, inhalation devices comprising formulations and combinations ... | 08/17/2010 |
| 7763640 | Substituted oxyguanidines The present application relates to new substituted oxyguanidines of structure (I) a method for their preparation and their use for the control of animal pests, mainly arthropods, in particular insects. ... | 07/27/2010 |
| 7754744 | Substituted piperidinamines as somatostatin receptor subtype 5 (SSTR5) antagonists This invention is concerned with compounds of the formula and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their prepara... | 07/13/2010 |
| 7745468 | Compounds for treatment of cell proliferative diseases The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of... | 06/29/2010 |
| 7741346 | Angiogenesis inhibitor An object of the present invention is to find new pharmacological actions of urea compounds having structure represented by the general formula [1]. The urea compounds having the structure represented by the general formula [1] have excellent angiogenesis inhibitory... | 06/22/2010 |
| 7737165 | Methods of reducing weight gain associated with olanzapine treatment A method of reducing weight gain associated with olanzapine treatment in a human subject, by orally administering to an olanzapine-treated subject betahistine or a salt thereof, is disclosed. ... | 06/15/2010 |
| 7728015 | Compositions for weight management Pharmaceutical compositions are disclosed comprising betahistine, or a salt thereof, and olanzapine in amounts effective to reduce the weight gain associated with olanzapine administration. ... | 06/01/2010 |
| 7723364 | N-[2-(2-pyridinyl) ethyl]benzamide compounds and their use as fungicides Compound of general formula (I): Process for preparing this compound. Fungicidal composition comprising a compound of general formula (I). Method for treating plants by applying a compound of general formula (I)... | 05/25/2010 |
| 7709507 | Therapeutic fluoroethyl ureas Compounds of the formula or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein A and B are as described herein, are useful for treating conditions afflicting mammals. ... | 05/04/2010 |
| 7687525 | Cell differentiation inducer The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune... | 03/30/2010 |
