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| Number | Title | Issue Date |
| 8093274 | Inhibitors of protein prenyltransferases The present invention is directed to novel compounds. These compounds can be useful in inhibiting the activity of GGTase I. The compounds can also be used as anti-cancer therapeutics including as part of methods for treating cancer, in assays, and in kits. ... | 01/10/2012 |
| 8017634 | Compositions for treating obesity and insulin resistance disorders Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activ... | 09/13/2011 |
| 8008328 | Methods for the treatment of diabetes-associated dyslipdemia Methods for the treatment of insulin resistance, diabetes, and/or diabetes associated dyslipidemia by administering niacin and meloxicam are disclosed. ... | 08/30/2011 |
| 7816384 | Method for treating a demyelinating condition Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca2+-channel blocker effective to treat the demyelinating condition. In other ... | 10/19/2010 |
| 7759369 | Pyridine compounds for the treatment of prostaglandin mediated diseases Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein X, Y, Z, R2a, R2b, R3a, R3b, R8, R9, and Rx are as defined i... | 07/20/2010 |
| 7759368 | Sustained release composition for oral administration of niacin A sustained release composition for oral administration of niacin, comprising niacin; a carrier for sustained release composed of a hydrophilic polymer and a hydrophobic polymer; and a pharmaceutically acceptable additive, the hydrophilic polymer being a polyethylen... | 07/20/2010 |
| 7655678 | Pharmaceutical composition for the management of tumors The present invention relates to the effect of naturally occurring compounds on tumor development. As an example of proof, we used low; non-toxic doses of three compound e.g. Calcium D-glucarate, a naturally occurring Ca++ salt of D-glucaric acid; Nicotin... | 02/02/2010 |
| 7442714 | Amlodipine gentisate and a method of its preparation The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and ... | 10/28/2008 |
| 7425319 | Method for enhancing protective cellular responses to genotoxic stress in skin The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses... | 09/16/2008 |
| 7419655 | Skin care products The invention provides compositions and methods for conditioning the skin and reversing the effects of aging on the skin. ... | 09/02/2008 |
| 7381434 | Methods and compositions of This invention comprises methods and compositions of Areca catechu . Methods of the present invention comprise extracting plant material of Areca catechu so that compositions having characteristics different from those of native plant materials are obt... | 06/03/2008 |
| 7381427 | Seborrheic keratosis treatment The subject of the present invention is seborrheic keratosis removal and prevention utilizing safe dependable effective biocompatible treatments with no scarring, bleeding, burning, freezing, shocking, and hypopigmentation or hyperpigmentation. ... | 06/03/2008 |
| 7371396 | Dermatological and cosmetic compositions The present invention relates to a dermatological and/or cosmetic composition comprising a furfuryl derivative of formula (I), and its use in the treatment of dermatological disorders especially when caused by free radicals. ... | 05/13/2008 |
| 7348317 | Aqueous compositions containing metronidazole An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a cyclodextrin such as beta-cyclodextrin and the second is niacin or niacinamid... | 03/25/2008 |
| 7341719 | Myoblast therapy for cosmetic treatment Compositions and methods of treating mammalian diseases using myoblasts, and/or their physical, genetic, chemical derivatives. Myogenic cells that are normal, or genetically or phenotypically altered are cultured and transplanted into malfunctioning and/or degenerat... | 03/11/2008 |
| 7335380 | Amlodipine free base Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine fr... | 02/26/2008 |
| 7332152 | Cosmetic composition A cosmetic composition is provided comprising vitamin B6, vitamin B3 and an organic acid. The components of the composition interact synergistically to enhance skin lightening. ... | 02/19/2008 |
| 7326705 | Heterocyclic sodium/proton exchange inhibitors and method Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or CāR5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, al... | 02/05/2008 |
| 7326422 | Dissolvable oxides for biological applications Controllably dissolvable silica-xerogels prepared via sol-gel process and their use. A delivery device including controllably dissolvable silica-xerogel into which structure a biologically active agent is incorporated. Pharmaceutical preparations including this devi... | 02/05/2008 |
| 7326730 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and composi... | 02/05/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7312232 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having the structural formula wherein X is oxygen, nitrogen or sulfur; Y is selected from the group consisting of oxygen, nitrogen and sulfur wherein w... | 12/25/2007 |
| 7309713 | Use of the non-opiate analgesic drug flupirtine for the treatment of overactive bladder and associated diseases including urge incontinence, urinary flow problems as a result of prostate hyperplasia and irritable bowel syndrome The present invention is directed to the prevention, reversal and medical treatment of lower urinary tract dysfunction including bladder instability and other related diseases as described below including urinary flow problems, urgency and incontinence as a result o... | 12/18/2007 |
| 7309867 | Methods and apparatus for characterization of tissue samples The invention provides methods for determining the probability that a given region of a tissue sample contains tissue of a given category, such as CIN 1 (cervical intraepithelial neoplasia, grade 1), CIN 2/3 (cervical intraepithelial neoplasia grades 2 and/or 3), no... | 12/18/2007 |
| 7309800 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/18/2007 |
| 7303768 | Preparation of aqueous clear solution dosage forms with bile acids Compositions for pharmaceutical and other uses comprising clear aqueous solutions of bile acids which do not form any detectable precipitates over selected ranges of pH values of the aqueous solution and methods of making such solutions. The compositions of the inve... | 12/04/2007 |
| 7300954 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carbo... | 11/27/2007 |
| 7291442 | Photosensitive polymeric material for WORM optical data storage with two-photon fluorescent readout Image formation via photoinduced fluorescence changes in a polymeric medium with two-photon fluorescence readout of a multi-layer structure. Fluorophore-containing polymers, possessing one or more basic functional groups, underwent protonation in the presence of a p... | 11/06/2007 |
| 7291352 | Methods and compositions for oral delivery of Areca and mate' or theobromine The present invention comprises methods and compositions comprising Areca extract compositions and compositions comprising extracts of Ilex paraguariensis or theobromine. Methods of the invention comprise methods of making pharmaceutical or nutriceutic... | 11/06/2007 |
| 7291625 | Use of a vitamin combination for the treatment of pruritus and non-infective disorders involving itching and/or inflammation Use of a combination of two vitamin compounds, i.e. riboflavin (also known as vitamin B2) and nicotinic acid (also referred to as niacin) or, as an alternative thereto, the corresponding amide, i.e. nicotinamide or niacinamide (also known as vitamin PP) f... | 11/06/2007 |
| 7279492 | S-(ā)-amlodipine nicotinate and process for the preparation thereof The present invention provides a novel salt of S-(ā)-amlodipine, i.e., a nicotinic acid salt of S-(ā)-amlodipine, a process for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient. ... | 10/09/2007 |
| 7273856 | Linear basic compounds having NK-2 antagonist activity and formulations thereof Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of formula (I) ... | 09/25/2007 |
| 7270831 | Orally administrable opioid formulations having extended duration of effect Sustained release oral solid dosage forms of opioid analgesics are provided as multiparticulate systems which are bioavailable and which provide effective blood levels of the opioid analgesic for at least about 24 hours. A unit dose of the opioid analgesic contains ... | 09/18/2007 |
| 7259250 | C-nitroso compounds and use thereof A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less th... | 08/21/2007 |
| 7247645 | Dihydropyridine derivatives Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts ther... | 07/24/2007 |
| 7244749 | Compositions and methods for lowering plasma lipoprotein(a) and risk factors of cardiovascular diseases The present invention provides compositions and methods for lowering plasma Lp(a) levels in humans. The present invention provides compositions and methods for lowering the risk factors for cardiovascular diseases. Moreover, this invention provides therapeutic alter... | 07/17/2007 |
| 7241745 | Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I) as well as methods for their production, medicaments containing these compounds as well as their m... | 07/10/2007 |
| 7241456 | Formulations for topical delivery of bioactive substances and methods for their use The invention relates to topical delivery of bioactive agents. More particularly, the invention relates to anhydrous formulations for percutaneous absorption. The invention provides formulations that allow efficient topical delivery of high concentrations of bioacti... | 07/10/2007 |
| 7235255 | Biological bioadhesive compositions and methods of preparation and use The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is form... | 06/26/2007 |
| 7235570 | 1,4-dihydropyridine and pyridine compounds as calcium channel blockers The present invention is directed in part towards methods of modulating the function of calcium channels with pyridine- or 1,4-dihydropyridine-based compounds. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal co... | 06/26/2007 |
