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Apparatus for Simulating a High Five
A self-righting hand-arm configuration which is adapted to pivot when struck by a user, thereby simulating a "high five."
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| Number | Title | Issue Date |
| 8030336 | Nicotinamide-based kinase inhibitors A compound of the general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating tyrosine kinase-associated disease states in a subject using a compound of formula (I)... | 10/04/2011 |
| 7989479 | Use of a p38 kinase inhibitor for treating psychiatric disorders The use of 6-(S-Cyclopropylcarbamoyl-S-fluoro-2-methyl-phenyl)-N-(2,2-dimethylproyl)-nicotinamide, which is known in the art as a p38 kinase inhibitor in the treatment or prophlaxis of one or more psychiatric disorders. ... | 08/02/2011 |
| 7943643 | Aryl substituted pyridines and the use thereof This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is al... | 05/17/2011 |
| 7820701 | Amorphous lercanidipine hydrochloride and uses thereof The invention provides a substantially pure amorphous lercanidipine hydrochloride having a purity of at least 95% pure, preferably at least about 97% pure, more preferably at least about 99% pure, and still more preferably at least about 99.5% pure. The invention fu... | 10/26/2010 |
| 7732467 | Method for reducing amyloid deposition, amyloid neurotoxicity and microgliosis The present invention provides methods for reducing β-amyloid deposition, β-amyloid neurotoxicity and microgliosis in animals or humans afflicted with a cerebral amyloidogenic disease, such as Alzheimer's disease (AD), by administering therapeutically effective am... | 06/08/2010 |
| 7709506 | Nicotinamide derivatives useful as p38 inhibitors Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38. ... | 05/04/2010 |
| 7612103 | Pleuromutilin derivatives as antimicrobials Compounds of formula wherein R1 and R1′ are hydrogen or deuterium, R2, R3 and R4 are hydrogen or deuterium, R5 is th... | 11/03/2009 |
| 7579367 | Aryl substituted pyridines and the use thereof This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is al... | 08/25/2009 |
| 7560473 | Amine derivative with potassium channel regulatory function, its preparation and use The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The inv... | 07/14/2009 |
| 7514456 | Nicotinamide derivatives useful as p38 inhibitors Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38. ... | 04/07/2009 |
| 7491721 | Antimycobacterial pharmaceutical composition An antimycobacterial combination and composition for treating tuberculosis are described. The compounds used are N-(3-[[4-(3-trifluoromethylphenyl)piperazinyl]methyl]-2-methyl-5-phenyl-pyrrolyl)-4-pyridylcarboxamide of formula (I) or a pharmaceutically acceptable no... | 02/17/2009 |
| 7476686 | Substituted aryl thioureas and related compounds; inhibitors of viral replication The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds o... | 01/13/2009 |
| 7476685 | Pyridine carboxamide derivatives and their use as pesticides The invention relates to 3-pyridylcarboxamide derivatives of the formula (I): wherein the various symbols are as defined in the description, compositions thereof, methods for controlling pests by applying same, and processe... | 01/13/2009 |
| 7390509 | Compositions and methods for nutrition supplementation The present invention relates to compositions comprising various vitamins and minerals and methods for using these compositions for nutritional supplementation in, for example, pregnant or lactating subjects. ... | 06/24/2008 |
| 7371396 | Dermatological and cosmetic compositions The present invention relates to a dermatological and/or cosmetic composition comprising a furfuryl derivative of formula (I), and its use in the treatment of dermatological disorders especially when caused by free radicals. ... | 05/13/2008 |
| 7365068 | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds o... | 04/29/2008 |
| 7358214 | Pyrazolyl carboxanilides for controlling unwanted microorganisms This invention relates to novel pyrazolylcarboxanilides of the formula (I) in which R1, G and n are as defined in the disclosure, to a plurality of processes for preparin... | 04/15/2008 |
| 7354595 | High concentration dinotefuran formulations A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative... | 04/08/2008 |
| 7351825 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/01/2008 |
| 7348350 | Pyrazolyl biphenyl carboxamides and the use thereof for controlling undesirable microorganisms Novel pyrazolylbiphenylcarboxamides of the formula (I) in which R1, R2, X, m, Y and n are each as defined in the description, a plurality of processe... | 03/25/2008 |
| 7338962 | Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us... | 03/04/2008 |
| 7338667 | Pharmaceutical formulation The present invention concerns an extended release formulation having an accelerating erosion and/or dissolution rate of the surface of the formulation. The formulation comprises a drug having low solubility in water dispersed or dissolved in at least one erasable h... | 03/04/2008 |
| 7335380 | Amlodipine free base Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine fr... | 02/26/2008 |
| 7335661 | Fungicidal mixtures Fungicidal mixtures, comprising A) the triazolopyrimidine of the formula I and B) amide compounds of the formula II ... | 02/26/2008 |
| 7335384 | Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease states and conditions associated with neurogenic inflammation. Such dis... | 02/26/2008 |
| 7329633 | Disubstituted pyrazolylcarboxanilides This invention relates to novel pyrazolylcarboxanilides of formula (I) in which R, R1, R2 and R3 are as defined in the disclosure, to a plurality of processes for preparing these ... | 02/12/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7309800 | Biphenylcarboxylic amide derivatives as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/18/2007 |
| 7282497 | Pyrrolidin-2-one derivatives as inhibitors of factor xa The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical con... | 10/16/2007 |
| 7279131 | Method and apparatus for mass analysis of samples The present invention comprises an apparatus and a method for mass analyses of an array of samples contained in distinct sample holders. The sample holders are placed on a plurality of sensors which preferably comprise an array of microbalances providing output sign... | 10/09/2007 |
| 7276500 | Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings:... | 10/02/2007 |
| 7259184 | Ion channel modulating compounds and uses thereof Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatme... | 08/21/2007 |
| 7244759 | Isoindoline compounds and methods of making and using the same The invention encompasses isoindoline compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment, prevention or management of various diseases and disorders. Examples include, but are not limited to, cancer, inflammatory bowel... | 07/17/2007 |
| 7244749 | Compositions and methods for lowering plasma lipoprotein(a) and risk factors of cardiovascular diseases The present invention provides compositions and methods for lowering plasma Lp(a) levels in humans. The present invention provides compositions and methods for lowering the risk factors for cardiovascular diseases. Moreover, this invention provides therapeutic alter... | 07/17/2007 |
| 7244750 | Active substance combinations having insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/17/2007 |
| 7235571 | Heterocyclic amide and imine derivatives, processes for their preparation, compositions comprising them and their use as pesticides What is described are compounds of the formulae (I) and (II) where the symbols and indices have the meanings given in the description. These compounds are suitable for controlling animal pests. ... | 06/26/2007 |
| 7235570 | 1,4-dihydropyridine and pyridine compounds as calcium channel blockers The present invention is directed in part towards methods of modulating the function of calcium channels with pyridine- or 1,4-dihydropyridine-based compounds. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal co... | 06/26/2007 |
| 7229999 | Pyridine-3-carboxamide derivatives as CB1 inverse agonists The present invention relates to compounds of the formula wherein X and R1 to R8 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds ar... | 06/12/2007 |
| 7226929 | Pyrrolidin-2-one derivatives as inhibitors of factor xa The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical con... | 06/05/2007 |
| 7223774 | Benzamide 2-hydroxy-3-diaminoalkanes The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 05/29/2007 |
