Class 514/351 - Nitrogen attached indirectly to the six-membered hetero ring by nonionic bonding

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein nitrogen is attached indirectly to
No. of patents: 502
Last issue date: 04/17/2012

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Number	Title	Issue Date
8158659	Dual-acting imidazole antihypertensive agents The invention is directed to compounds having the formula: wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT	04/17/2012
8110587	Aryl ureas as kinase inhibitors This invention relates to new aryl ureas and methods for their synthesis. The inventive compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated...	02/07/2012
8067445	N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin Dreceptors Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are ...	11/29/2011
8053451	Hydroxybenzoate salts of metanicotine compounds Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hyd...	11/08/2011
8048898	Inhibitor of binding of S1P A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: (wherein Y1 represents a nitrogen atom or a group represented by CRA, Y2 represents a nitrogen atom or a ...	11/01/2011
8044074	Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them The invention relates to compounds of formula I in which R1, R2, R3, R4, R5, R6 and X have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredients, in particular for t...	10/25/2011
8003672	CB-1 receptor modulator formulations Described herein are solid, stable pharmaceutical formulations of cannabinoid receptor inverse agonists, such as taranabant, and processes of making such formulations. Additionally, described herein are solid stable pharmaceutical formulations of cannabiniod inverse...	08/23/2011
7879884	Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the u...	02/01/2011
7875636	Pyridyl amide T-type calcium channel antagonists The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed...	01/25/2011
7812037	Dual antiplatelet/anticoagulant pyridoxine analogs Compounds with antiplatelet aggregation and anticoagulant characteristics for the treatment of cardiovascular, cerebrovascular, and cardiovascular related diseases and symptoms, are described. The methods are directed to administering pharmaceutical compositions com...	10/12/2010
7759367	Pharmaceutical compositions and their uses The present invention relates to compositions comprising 1,2-dihydropiridin-2-one compounds and an immunoregulatory or anti-inflammatory agent. The compositions are useful for the prevention or the treatment of neurodegenerative diseases, for example demyelinating d...	07/20/2010
7674807	Heterocycle-substituted n-phenyl-phthalamide derivatives, related compounds and their use as insecticides Novel benzenedicarboxamides of the formula (I) wherein X represents hydrogen, halogen atom, nitro, C1-6alkylsulfonyloxy, C1-6alkylsulfinyl, C1-6alkylsulfenyl or C1-6alkylsulfonyl, R1 represents C1-6al...	03/09/2010
7674808	Heterocyclic compounds 4-pyridone (4-pyridinone) derivatives of Formula I and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical formulations thereof and their use in chemotherapy of certain parasitic...	03/09/2010
7655677	Composition and method for controlling house insect pest The present invention provides a composition for controlling a house insect pest, such as termites, ants or cockroaches, which comprises, as active ingredients, at least two compounds selected from the group consisting of (a) a certain pyridine compound, (b) a benzo...	02/02/2010
7629365	Heterocyclic compounds 3-Chloro-6-(hydroxymethyl)-2-methyl-5-[4-({4-[(trifluoromethyl)oxy]phenyl}oxy)phenyl]-4(1H)-pyridinone, having the following formula: is described along with its pharmaceutically acceptable salts, processes for its preparat...	12/08/2009
7459469	Hydroxybenzoate salts of metanicotine compounds Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hyd...	12/02/2008
7425570	Pyridoxine and pyridoxal analogues: new uses The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions containing a therapeutically effective amount of at least one of these anal...	09/16/2008
7425319	Method for enhancing protective cellular responses to genotoxic stress in skin The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses...	09/16/2008
7417059	Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of d...	08/26/2008
7329670	Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or heteroaryl moiety. The compounds inhibit raf kinase and are useful in the tre...	02/12/2008
7326730	Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and composi...	02/05/2008
7323452	Method for the accelerated in vivo removal of ethanol A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives...	01/29/2008
7320993	Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ...	01/22/2008
7307092	Compounds Capable of Activating Cholinergic Receptors Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5...	12/11/2007
7291731	N-aryl diazaspiracyclic compounds and methods of preparation and use thereof Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are N-aryl diazaspirocyclic compounds, bridged analogs of N-heteroaryl diazaspirocyclic compounds, or prodrugs or metabolites of t...	11/06/2007
7282496	Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and TACE inhibitors Compounds of the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease, degenera...	10/16/2007
7262209	Carbonyloxy-cyanomethyl compounds as antiparasitic agents The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances gi...	08/28/2007
7259157	N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ...	08/21/2007
7253189	Cannabinoid receptor ligands A compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: R1, R2, L1, L2, M1, M2, n, p, q, A, D, X, Y and Z are...	08/07/2007
7253211	(R)-chiral halogenated substituted fused heterocyclic amino compounds useful for inhibiting cholesterol ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for ...	08/07/2007
7235566	Pyridinone derivatives for treatment of atherosclerosis Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. ...	06/26/2007
7230017	Dihydropyridinone derivatives The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failur...	06/12/2007
7217682	Cyclopropanecarboxylic acid esters and pest controllers containing the same A 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 2,2-dimethyl-3-(2-cyano-3-hydrocarbyloxy-3-oxo-1-propenyl) cyclopropanecarboxylate given by the formula (1): wherein G represents C1–C4 alkyl or C3–C4 alkenyl, has ...	05/15/2007
7214686	Pharmaceutical compositions and methods for effecting dopamine release Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attent...	05/08/2007
7214701	Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ...	05/08/2007
7208506	Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and...	04/24/2007
7202260	VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones Novel VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones and their use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are selected. ...	04/10/2007
7196102	Calcium receptor modulating agents The compounds of the invention are represented by the following general structure or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and the...	03/27/2007
7195773	Pesticidal composition A pesticidal composition comprising a pesticidally effective amount of at least one of a pyridic compound of the formula (I) or it salt and at least one of other pesticides: wherein Y is a haloalkyl group, m is 0 or 1, and Q is or a substituted or unsubstituted hete...	03/27/2007
7195891	Methods and compositions of enzymatic cycling based assays for myeloperoxidase The present invention provides a method for assaying myeloperoxidase activity. In the assay, a sample containing myeloperoxidase or suspected of containing myeloperoxidase is contacted with substrate including serine, hydrogen peroxide, and a halide. If myeloperoxid...	03/27/2007

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Class 514/351 - Nitrogen attached indirectly to the six-membered hetero ring by nonionic bonding