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Class 514/35 - Oxygen of the saccharide radical bonded directly to a cyclohexyl ring


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein a cyclohexyl radical is bonded directly
No. of patents: 129
Last issue date: 10/18/2011


1        
NumberTitleIssue Date
8039442Compounds and methods for treatment of sickle cell disease or complications associated therewith
Compounds, compositions and methods are provided for treatment of sickle cell disease or a complication associated therewith, or graft versus host disease, in an individual. More specifically, the use of particular glycomimetics for the treatment is described. ...
10/18/2011
8026222Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
Methods are provided for using a compound to treat, for example, endothelial dysfunction including vascular abnormalities. More specifically, methods are described for using an oligosaccharide compound or glycomimetic compound wherein a cyclohexane derivative is inc...
09/27/2011
8003617Methods of treating diabetes mellitus
The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject. ...
08/23/2011
7964569Glycomimetic replacements for hexoses and N-acetyl hexosamines
Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or substituting in a cyclohexane derivative. ...
06/21/2011
7928079Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
The invention relates to compounds capable of releasing nitric oxide wherein the compounds comprise a saccharide and at least one nitric oxide-releasing diazeniumdiolate [N2O2] functional group, which is bonded directly to a carbon atom of the ...
04/19/2011
7759317Analgesic and anti-inflammatory compositions and methods with flavonoid glycoside-type compounds
The present invention relates to pharmaceutical compositions containing certain flavonoid glycoside-type compounds that have been shown in the present invention to be therapeutically useful, including useful as analgesics and anti-inflammatories for the treatment an...
07/20/2010
7749971Aminoglycoside treatment for lysosomal storage diseases
The present invention provides a method of treating lysosomal storage diseases such as Hurler syndrome and Batten disease in individuals in need of such treatment, comprising the step of administering to said individuals a therapeutically effective dose of an aminog...
07/06/2010
77499721-substituted-7-(β-D-glycopyranosyloxy)(aza)indole compound and pharmaceutical containing the same
The present invention provides a compound having an SGLT1 and/or SGLT2 inhibitory activity which is usable as an agent for the prevention or treatment of diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity or the like.
07/06/2010
7687472Methods and compositions for treating hyperglycemic, hyperlipidemic, or hyperinsulinemic disorders
Methods of treating hyperglycemic, hyperlipidemic, and hyperinsulinemic disorders are provided. Compositions for treating such disorders are also provided. The compositions can include hexose and pentose variants having acid moieties and a substituent Y linked to th...
03/30/2010
7655633Nitrogen-containing heterocyclic derivatives, medicinal compositions containing the same and medicinal use thereof
The present invention provides nitrogen-containing heterocyclic derivatives represented by the general formula: wherein X1 represents N or CR1; X2 represents N or CR2; X3
02/02/2010
7605136Effector conjugates, methods for their preparation and their pharmaceutical use
Conjugates of epothilones and epothilone derivatives (as effectors) with suitable saccharides or saccharide derivatives (as recognition units) are described. Their production is carried out by the recognition units being reacted with suitable linkers, and the compou...
10/20/2009
7572774Methods for treating glutamate cytotoxicity with beta-naphthoquinone compounds
The present invention relates to the use of beta-naphthoquinone derivatives, and salts thereof, for the prevention and/or the treatment of glutamate cytotoxicity. It further relates to the use of beta-naphthoquinone derivatives, and salts thereof, for preventing and...
08/11/2009
7429568Glucopyranosyloxypyrazole derivatives and use thereof in medicines
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a gr...
09/30/2008
7393838Glucopyranosyloxypyrazole derivatives and use thereof in medicines
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug; one of Q and T represents a
07/01/2008
7374747Pharmaceutical foam
The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized contained comprising a quick-breaking alcoholic foaming agent, such that when the composit...
05/20/2008
7371733Anti bacterial compounds
The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics. Paranmycins are of the general formula ...
05/13/2008
7345024Pharmaceutical preparation, method for its production as well as its use
The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have as their cationic component one of the antibiotics gentamicin, clinda...
03/18/2008
7335753Bifunctional heterocyclic compounds and methods of making and using same
The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using...
02/26/2008
7323452Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives...
01/29/2008
73122009-ketospinosyn derivatives
The present invention relates to derivatives of 9-keto spinosyns, which are substituted by a ═N—(O, NH or NRx)—Ry moiety in the C-9 position, to methods for their manufacture, and to their use for controlling animal pests. ...
12/25/2007
7294618Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1, R2 and R3 represent a hydrogen atom or a halogen atom; R4...
11/13/2007
7244712Aminoglycoside antibiotics and methods of using same
The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses antibiotic activity and are not susceptible to development of resistant...
07/17/2007
7241746Method and composition for treating periodontal disease
The present invention is directed to a pharmaceutical composition comprising a therapeutically effective amount of misoprostol and an effective amount of an antibiotic. A suitable antibiotic is selected from the group consisting of doxycycline, gentamicin, tobramici...
07/10/2007
7232805Cobalamin conjugates for anti-tumor therapy
The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a...
06/19/2007
7220727Aminoglycosides as antibiotics
The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human). ...
05/22/2007
7214759Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same
Polymers containing polyesters and, optionally, agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a...
05/08/2007
7189702Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula:
03/13/2007
7182954Prebiotic oligosaccharides via alternansucrase acceptor reactions
Oligosaccharides produced by an alternansucrase enzyme catalyzed reaction of sucrose with an acceptor oligosaccharide are effective as prebiotics for controlling enteric bacterial pathogens. Populations of enteropathogenic bacteria may be substantially reduced or in...
02/27/2007
7166611Pharmaceutical compositions having appetite suppressant activity
A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for obtaining the extract and a process for synthesizing compound (1...
01/23/2007
7157078Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to ...
01/02/2007
7153877Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bo...
12/26/2006
7144867Anticancer glycoside compounds
The present invention relates to new classes of anti-cancer compounds. In particular, the present invention provides glycoside compounds as anti-cancer agent, alone, or in combination with other anti-cancer agents or therapies. ...
12/05/2006
7141237Pharmaceutical foam
The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized container comprising a quick-breaking alcoholic foaming agent, such that when the composit...
11/28/2006
7129218Use of rhamnolipids in wound healing, treatment and prevention of gum disease and periodontal regeneration
Various methods are provided, including re-epithelization and wound healing with reduced fibrosis, particularly for the re-epithelization of mucous membrane tissues, most particularly for the treatment and prevention of gum disease and for periodontal regeneration, ...
10/31/2006
7128897Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
Pharmaceutical compositions are described that contain one agent for treatment of sinusitis and a surfactant. The compositions are prepared to have a surface tension that renders the composition effective for treatment of sinusitis. ...
10/31/2006
7119110Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bo...
10/10/2006
7091196Bifunctional heterocyclic compounds and methods of making and using same
The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents,...
08/15/2006
7087579Glucopyranosyloxypyrazole derivatives and medicinal use thereof
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein one of Q and T represents a group represented by the general formula:
08/08/2006
7084123Glucopyranosyloxypyrazole derivatives and use thereof in medicines
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R represents a hydrogen atom, a lower alkyl group or a group forming a prodrug: one of Q and T repr...
08/01/2006
7053060Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
The present invention relates to glucopyranosyloxybenzylbenzene derivatives represented by the general formula: wherein R1 represents a hydrogen atom, a hydroxy group, a substituted or unsubstituted am...
05/30/2006
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