Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 8173684 | Pyridone derivatives as p38α MAPK inhibitors A compound represented by the formula (I): wherein R1 is lower alkyl, cycloalkyl or aromatic hydrocarbon ring, each of which is optionally substituted with one or more substituents; R2 is hydrogen atom, halogen atom, lower alkyl, halo(lower)alk... | 05/08/2012 |
| 8093272 | Heteroaryl substituted cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including the... | 01/10/2012 |
| 7960415 | Caspase inhibitors and uses thereof The present invention provides a compound of formula I: wherein R1, R2, R3, R4, and R5 are as defined herein. The present invention also provides pharmaceutical composi... | 06/14/2011 |
| 7897624 | Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors This invention concerns N-(ortho phenylamino dihydropyridyl)sulfonamides and N-(ortho phenylamino dihydropyridyl), N′-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases. ... | 03/01/2011 |
| 7816382 | Linear urea mimics antagonists of P2Yreceptor useful in the treatment of thrombotic condition The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as d... | 10/19/2010 |
| 7772258 | Agent for treatment of allergic eye disease An agent for the treatment of allergic eye disease containing a 3-anilino-2-cycloalkenone derivative having the formula (I): wherein R1 is an unsubstituted or substituted C1 to C8 alkyl grou... | 08/10/2010 |
| 7714002 | Carbocycle and heterocycle antagonists of P2Yreceptor useful in the treatment of thrombotic conditions The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as d... | 05/11/2010 |
| 7585883 | Substituted pyridines and their uses The present invention is directed to substituted pyridines, methods for their preparation and methods for their use in the treatment and/or prevention of mast cell related conditions. ... | 09/08/2009 |
| 7378446 | Compound having anti-HCV activity and process for producing the same The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV,... | 05/27/2008 |
| 7354946 | Biarylurea derivatives The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a c... | 04/08/2008 |
| 7329670 | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or heteroaryl moiety. The compounds inhibit raf kinase and are useful in the tre... | 02/12/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7273877 | 5-substituted-4-[(substituted phenyl) amino]-2-pyridone derivatives The present invention relates to 5-substituted-4-(substituted)phenylamino-2-pyridone derivatives, pharmaceutical compositions and methods of use thereof. ... | 09/25/2007 |
| 7271181 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 09/18/2007 |
| 7251447 | Image heating apparatus and conveying roller for use therein An image heating apparatus for heating an image formed on a recording material, the apparatus including a conveying roller for conveying a recording material, the conveying roller including a metal core and an elastic layer provided outside the metal core, wherein t... | 07/31/2007 |
| 7226936 | Pyridinic sulfonamide derivatives method of production and use thereof New pyridinic sulfonamide derivatives represented by a general formula (I), wherein R1, represents a mono- or polyhalogenated C1–12-alkyl or a mono- or poly-halogenated C3–8-cycloalkyl group. The method of production of such derivatives and their use as active t... | 06/05/2007 |
| 7224922 | Image fixing apparatus capable of changing surface condition of fixing rotary member and fixing rotary member for use therein A fixing apparatus including a rotatable member, a heater for heating the rotatable member, and control means which controls heat generation of the heater, wherein a toner image on a recording material is heated by the rotatable member, the apparatus has a surface c... | 05/29/2007 |
| 7223778 | 5-substituted-2-arylpyridines Novel 5-substituted-2-arylpyridine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyridine compounds provided herein are useful in the treatment of a number of CNS and periphereal disorders, particula... | 05/29/2007 |
| 7187878 | Image forming apparatus and its control method In continuous printing operation which repeatedly sets a state in which when a preceding printing material passes through the nip area of a thermal fixing unit, a succeeding printing material has been supplied to an image forming unit and image forming operation has... | 03/06/2007 |
| 7166586 | Sulfonamide lactam inhibitors of FXa and method Sulfonamide lactams of the following formula wherein X, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and ... | 01/23/2007 |
| 7151112 | Pharmaceutical uses and synthesis of nicotinamides This invention is directed to methods of using a compound of the formula and pharmaceutically acceptable salts thereof, wherein n, X, R1 and R2 are disclosed herein, for treating inflammator... | 12/19/2006 |
| 7138417 | Inhibitors of integrin αβ Novel biphenyl derivatives of the general formula I in which R1, R1′, R1″, R2, R2′, R3 and n are as defined in Patent claim 1, stereoisomers thereof and physiologically acceptable salts or solvates ... | 11/21/2006 |
| 7132425 | 5-substituted-six-membered heteroaromatic glucokinase activators The present invention provides a compound according to formula I where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula I are ... | 11/07/2006 |
| 7129238 | Mandelic acid derivatives The invention is concerned with novel mandelic acid derivatives of formula (I) wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acc... | 10/31/2006 |
| 7130572 | Image heating apparatus using a flexible sleeve The image heating apparatus for heating an image formed on a recording material includes a flexible sleeve and a regulating member disposed at a position opposed to an end surface of the sleeve for regulating the movement of the sleeve in a generatrix direction ther... | 10/31/2006 |
| 7115605 | Peptide deformylase inhibitors PDF inhibitors and novel methods for their use are provided. ... | 10/03/2006 |
| 7109220 | Amino substituted pyridinyl methanone compounds useful in treating kinase disorders The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat or ameliora... | 09/19/2006 |
| 7107000 | Image heating apparatus having flexible sleeve The image heating apparatus for heating an image formed on a recording material, comprises a flexible sleeve; a driving roller which contacts an outer peripheral surface of said sleeve and rotates said sleeve; a sliding member which contacts an inner peripheral surf... | 09/12/2006 |
| 7074813 | Substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar1, A... | 07/11/2006 |
| 7056932 | Heterocyclyl substituted 1-alkoxy acetic acid amides The invention is concerned with novel heterocyclyl substituted 1-alkoxy acetic acid derivatives of formula (I) wherein R1 to R6 and A are as defined in the description and in the claims, as ... | 06/06/2006 |
| 7041670 | Florfenicol-type antibiotics The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such... | 05/09/2006 |
| 7037928 | Compositions of N-(methylethylaminocarbonyl)-4-(-3-methylphenylamino)-3-pyridylsulfonamide and cyclic oligosaccharides The invention relates to compositions of N-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridylsul fonamide and cyclic oligosaccharides with increased release, to methods for their preparation, to pharmaceutical froms containing them as well as to their us... | 05/02/2006 |
| 7030146 | Methods for treating diabetic neuropathy A method for treating diabetic neuropathy is disclosed consisting of administering pyridoxamine or a salt thereof. ... | 04/18/2006 |
| 7030145 | Pyridinyl derivatives for the treatment of depression The present invention relates to novel heterocyclic antagonists of Formula (I) and pharmaceutical compositions comprising said antagonists of the corticotropin releasing factor receptor (“CRF receptor”) useful for t... | 04/18/2006 |
| 7030110 | Cyclic oxyguanidine pyrazinones as protease inhibitors Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I: wherein R3, R4, R5, W, and A are as set forth in the specification, as well as hydrates, sol... | 04/18/2006 |
| 7029654 | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors Aminoguanidine and alkoxyguanidine compounds are described, including compounds of the Formula VII: wherein X is O or NR9 and Het, R1, R7, R8, R12—R15,... | 04/18/2006 |
| 7015237 | Pyridine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydrox... | 03/21/2006 |
| 7008950 | Benzofurans as suppressors of neurodegeneration A compound of the formula: wherein R1 and R2 each is H or a hydrocarbon group which may be substituted, or R1 and R2 form a 3- to 8-membered carbo or heterocyclic ring which ... | 03/07/2006 |
| 6998589 | Image heating apparatus using flexible sleeve and sleeve thereof An image heating apparatus according to the present invention includes a fixing sleeve, a guide member that is arranged in an inner circumferential section of fixing sleeve and rotatably holds the fixing sleeve, a pressure roller that press-contacts with the guide m... | 02/14/2006 |
| 6972296 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of α4β1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such co... | 12/06/2005 |
