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| Number | Title | Issue Date |
| 8183266 | Methods The invention relates to the novel chemical compounds of the formula (I): (I) in free or salt form, its use in the treatment of NET and/or SERT mediated conditions, e.g., depression, vasomotor symptoms, e.g., hot flashes and other diseases or conditions mediated by ... | 05/22/2012 |
| 8163781 | Bi-aryl aminotetralines The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R5, A, B, Q, W, and X are defined in the detailed description and claims... | 04/24/2012 |
| 8067444 | Pyridoxamine for the treatment of diabetic intermediaries and post-amadori inhibition The present invention provides pharmaceutical compositions comprising dosage units of pyridoxamine, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier, and methods for their use in limiting the progression of renal disease and/o... | 11/29/2011 |
| 8026261 | Fluorinated derivatives of deferiprone The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, processes for the man... | 09/27/2011 |
| 7989478 | Cinnamoyl compound and use of the same The present invention relates to a cinnamoyl compound represented by the formula (I): ... | 08/02/2011 |
| 7973060 | Fab I inhibitor and process for preparing same A compound which is effective for inhibiting Fab I, and a method for treating a bacterial infection. ... | 07/05/2011 |
| 7906536 | Processes for the preparation of 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide This invention is directed generally to processes for the preparation of compounds of Formula I: wherein R2, R3, R4, R5, X1, X2, X3, X4... | 03/15/2011 |
| 7612101 | Abnormal cannabidiols as agents for lowering intraocular pressure The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula I | 11/03/2009 |
| 7547713 | O-pyridinequinone derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives The present invention relates to the o-pyridinequinone disubstituted derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives. The o-pyridinequinone disubstituted derivatives of the presen... | 06/16/2009 |
| 7538126 | Crystalline forms of valdecoxib The present invention relates to novel crystalline forms of valdecoxib, to processes for their preparation and to pharmaceutical compositions containing them. ... | 05/26/2009 |
| 7410985 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones The present invention provides an cycloalkyl derivative of 3-hydroxy-4-pyridinone which is useful for the chelation of metal ions such as iron. Its preparation and use is described. In particular, the invention concerns the removal of iron in chemical and biological... | 08/12/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7279474 | Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF) The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof wherein the variables are as defined in the description, processes for their preparation, pharmaceutical compositions ... | 10/09/2007 |
| 7255866 | Botulinum toxin therapy for fibromyalgia Methods for treating fibromyalgia by administering a therapeutically effective amount of a botulinum toxin to a patient with fibromyalgia. ... | 08/14/2007 |
| 7250418 | Compounds as CRFreceptor antagonists The present invention relates to compounds of Formula I, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compounds of the inventions are CRF1 receptor a... | 07/31/2007 |
| 7223760 | Substituted triazole compounds Novel substituted triazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ... | 05/29/2007 |
| 7196105 | Treatment of human multiple myeloma by curcumin All multiple myeloma cell lines examined showed constitutively active IκB kinase (IKK), IκBα phosphorylation and constitutively active NF-κB. Curcumin, a chemopreventive agent, suppressed constitutive IκBα phosphorylation through inhibition of IKK activity and... | 03/27/2007 |
| 7183278 | Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component Disclosed are novel compounds useful for the control of harmful organisms, harmful organism control agents using the same, and processes for producing the novel compounds. The useful novel compounds according to the present invention include compounds represented by... | 02/27/2007 |
| 7173055 | Pyrazolecarboxamide and pyrazolethioamide as fungicide Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R1 is C1–C3alkyl, C1–C3haloalkyl, C1–C3alkoxy-C1–C3alkyl or C1–C3 | 02/06/2007 |
| 7160482 | Composition comprising an oxidizing and complexing compound The present invention is related to a composition comprising an oxidizing compound and a complexing compound with the chemical formula wherein R1, R2, R3 and R4 are selected from the group consisting of H and any organic side chain. The oxidizing compound can be in ... | 01/09/2007 |
| 7151109 | Pyrazolo[1,5-a]pyridine derivatives and their use as neurotransmitter modulators The present invention relates to novel pyrazolo[1,5-a]pyridine derivatives of general formula I: that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This inventi... | 12/19/2006 |
| 7141589 | Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound. | 11/28/2006 |
| 7135196 | Iron compositions Compositions in solid form, such as powders, comprising a mixture of a ferrous salt and a hydroxypyrone maybe used to increase the level of iron in a patient's bloodstream or to treat and/or prevent gastrointestinal infection. ... | 11/14/2006 |
| 7122563 | Derivatives of 4-demethylpenclomedine, use thereof and preparation thereof Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided. ... | 10/17/2006 |
| 7087617 | Substituted pyrimidine derivatives This invention relates to compounds of Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, or a pharmaceutically acceptable salt of a prodrug thereof. The compounds i... | 08/08/2006 |
| 7074813 | Substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II: wherein Ar1, A... | 07/11/2006 |
| 7074791 | Pyrrolo[1,2-b]pyridazine compounds and their uses Disclosed are novel CRF receptor antagonists and their use as treatment of a variety of disorders, including disorders manifesting hypersecretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the inventi... | 07/11/2006 |
| 7067540 | Substituted pyridinones Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for ... | 06/27/2006 |
| 7049336 | Method for diagnosing neuronal diseases and for treating primary hemostasis deficiency Pharmaceutical compositions for treatment of primary hemostasis deficiency and methods of treatment of primary hemostasis deficiency are disclosed. Also, methods for diagnosing neuronal diseases and for suppressing the immune system are disclosed. Isoforms responsib... | 05/23/2006 |
| 7049328 | Use for deferiprone A method of treating iron induced cardiac disease in a patient with iron overload, such as in thalassemia or the like comprising administering to the patient a therapeutically effective amount of deferiprone or a physiologically acceptable salt thereof sufficient to... | 05/23/2006 |
| 7026338 | Pharmaceutical nitrones Pharmaceutical nitrone comprise condensates of an N-hydroxylamine and a physiological aldehyde, providing improved delivery and absorption, enhanced stability and reduced toxicity. Preferred physiological aldehydes are subject to endogenous cellular uptake transport... | 04/11/2006 |
| 7015237 | Pyridine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydrox... | 03/21/2006 |
| 7015229 | Substituted pyrimidinones and pyrimidinthiones This invention relates to substituted pyrimidinone and pyrimidithione derivatives that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or c... | 03/21/2006 |
| 7008950 | Benzofurans as suppressors of neurodegeneration A compound of the formula: wherein R1 and R2 each is H or a hydrocarbon group which may be substituted, or R1 and R2 form a 3- to 8-membered carbo or heterocyclic ring which ... | 03/07/2006 |
| 7008940 | Dihydrobenzofuran derivatives, process for the preparing thereof and agents A compound represented by the formula (I): or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production, wherei... | 03/07/2006 |
| 7005433 | Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 02/28/2006 |
| 6995166 | Method and composition for supplementation of nutritional deficiencies in renal patients The present invention relates to compositions and methods for treating the nutritional deficiencies observed in patients suffering from renal disease and associated disorders. Specifically, the method involves administering to a renal patient a composition comprisin... | 02/07/2006 |
| 6992087 | Substituted aryl 1,4-pyrazine derivatives Substituted aryl 1,4-pyrazine derivatives of formula I as defined herein and their use in treating anxiety disorders, depression and stress related disorders are disclosed. ... | 01/31/2006 |
| 6974827 | Phenyl substituted 4-hydroxy tetrahydroxypyridone The present invention relates to novel compounds of the formula (I) in which W, X, Y, Z, G, A, B, Q1, Q2 and D are each as defined in the description, to a plurality of p... | 12/13/2005 |
| 6967211 | Remedial agent for chronic articular rheumatism The present invention relates to an excellent remedial agent for chronic rheumatoid arthritis, comprising an aminostilbazole derivative represented by the following formula [1] or a salt thereof as an active ingredient: A-B-D-E [1] Wherein A... | 11/22/2005 |
