Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 7923460 | mutation T1796A in thyroid cancers The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma. We tested 476 primary tumors, including 214 lung, 126 head and neck, 54 thyroid, 27 bladder, 38 cervical, and 17 prostate cancers, for the BRAF T1796A mut... | 04/12/2011 |
| 7897623 | ω-carboxyl aryl substituted diphenyl ureas as p38 kinase inhibitors This invention relates to the use of a group of aryl ureas in treating p38 mediated diseases, and pharmaceutical compositions for use in such therapy. ... | 03/01/2011 |
| 7838540 | 3-aminocarbonyl, 6-phenyl substituted pyridine-1-oxides as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 11/23/2010 |
| 7666884 | N-(2-substituted phenyl)-N-methoxycarbamates and their preparation and use thereof The present invention belongs to the field of agricultural fungicide and in particular disclosed N-(2-substituted phenyl)-N-methoxycarbamates and their preparation as well as use. Compounds according to the present invention are shown as the general formula I. | 02/23/2010 |
| RE40703 | Cell differentiation inducer, benzamide compounds The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune... | 04/28/2009 |
| 7468382 | Pyridine derivatives useful as inhibitors of PKC-theta Disclosed are novel compounds of formula (I): wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases ... | 12/23/2008 |
| 7456203 | Muscarinic receptor antagonists Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic recepto... | 11/25/2008 |
| 7427618 | Ethynyl derivatives as factor Xa inhibitors Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic di... | 09/23/2008 |
| 7425570 | Pyridoxine and pyridoxal analogues: new uses The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions containing a therapeutically effective amount of at least one of these anal... | 09/16/2008 |
| 7358271 | Sulpiride pharmaceutical compositions The present invention relates to pharmaceutical compositions containing sulpiride compounds having the general formula: where R1 is branched or straight chain alkyl having from 1 to about 7 carbon atoms, a substi... | 04/15/2008 |
| 7332518 | Carboxamides as fungicides in agriculture The invention concerns novel carboxamides of formula (I) wherein A is (A1), (A2), (A3), (A4), (A5); Q is (Q1), (Q2), (Q3), (Q4), (Q5), (Q6); R1 is CH2 R2, CH2CH═CHR2, CH═C═CHR2 or COR3 | 02/19/2008 |
| 7273867 | Phenyl derivatives Novel compounds of the formula I in which W, X, Y, T, R1 and R2 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders | 09/25/2007 |
| 7271183 | 2-Piperidone derivatives as prostaglandin agonists The invention provides compounds of the Formula: wherein m, n, A, X, Y, Z, R1, R2, R4, R6, R7, R8, R9 and R10 are as defined... | 09/18/2007 |
| 7265220 | Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative Compound of formula (I): wherein: R1 represents aryl, heteroaryl or alkyl which is optionally substituted, or a group of formula —(CO)—CR6R7NR8R9 ... | 09/04/2007 |
| 7262211 | Aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have at a group having a guanidino moiety or derivative thereof. These compounds are useful in ... | 08/28/2007 |
| RE39754 | Benzamide derivatives and pharmaceutical compositions containing same The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune... | 07/31/2007 |
| 7235566 | Pyridinone derivatives for treatment of atherosclerosis Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. ... | 06/26/2007 |
| 7229999 | Pyridine-3-carboxamide derivatives as CB1 inverse agonists The present invention relates to compounds of the formula wherein X and R1 to R8 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds ar... | 06/12/2007 |
| 7196100 | Opioid receptor antagonists A compound of the formula (I) wherein the variables X1 to X5, R1 to R7 including R3′, E, q, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer... | 03/27/2007 |
| 7184829 | Method and system for nerve stimulation prior to and during a medical procedure A method of performing a medical procedure, such as surgery, is provided. A nerve is stimulated in order to adjust the beating of the heart to a first condition, such as a stopped or slowed condition. The medical procedure is performed on the heart or another organ.... | 02/27/2007 |
| 7179822 | Hetero biaryl derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable... | 02/20/2007 |
| 7176310 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents This invention is directed to compound of the following formula (I): wherein R1, R2, R3 and R4 are as described herein. These compounds and pharmaceutical compositions ... | 02/13/2007 |
| 7141609 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 11/28/2006 |
| 7078400 | 20-HETE synthase inhibitor The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or pharmaceutically-acceptable salts thereof. The inhibitors according to the present inv... | 07/18/2006 |
| 7067553 | Thiourea compounds and the pharmaceutical compositions containing the same The present invention relates to thiourea compounds and the pharmaceutical compositions containing the same, and particularly, to novel thiourea compounds as an antagonist against vanilloid receptor (VR) and the pharmaceutical compositions thereof. As diseases assoc... | 06/27/2006 |
| 7045512 | Fungicidal phenoxyphenylhydrazine derivatives A fungicidally active compound of the formula: a) wherein Q is —NY—NH—, —N═N—, or X is oxygen... | 05/16/2006 |
| 7041691 | Compounds for the modulation of PPARγ activity Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 05/09/2006 |
| 7026339 | Inhibitors of HCV NS5B polymerase The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions contai... | 04/11/2006 |
| 7022695 | Thioether-substituted benzamides as inhibitors of Factor Xa Thioether-substituted benzamide compounds having the formula: are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding. ... | 04/04/2006 |
| 6992081 | Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formulas (XII) (XIII), and (XIV) useful in treating Alzheimer's disease and other similar diseases. ... | 01/31/2006 |
| 6979695 | Compounds capable of activating cholinergic receptors The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via admini... | 12/27/2005 |
| 6977266 | Pyridone derivatives having affinity for cannabinoid 2-type receptor It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R1 is a group represented by the formula: —Y1... | 12/20/2005 |
| 6949539 | Admantane derivatives The invention provides compounds of general formula (I) in which m, A, R1 and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compo... | 09/27/2005 |
| 6949573 | Nicotinamide derivatives useful as PDE4 inhibitors The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful... | 09/27/2005 |
| 6936626 | Retinoic acid mimetic anilides The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents O, S or NR3; R | 08/30/2005 |
| 6927225 | Fungicidal 2-pyridyl alkyl amides and their compositions, methods of use and preparation The present invention relates to compounds of Formula I: wherein: represents a 6-membered heterocyclic aromatic ring in which X1 is N, and X2, X | 08/09/2005 |
| 6912419 | Method and device for electronically controlling the beating of a heart An electro-stimulation device includes a pair of electrodes for connection to at least one location in the body that affects or regulates the heartbeat. The electro-stimulation device both electrically arrests the heartbeat and stimulates the heartbeat. A pair of el... | 06/28/2005 |
| 6911451 | Phenylalanine derivatives Phenylalanine derivatives of formula (1) are described: wherein L1 is a linker atom or group; X1 is a group selected from —N(R3)CO—, —N(R3)SO | 06/28/2005 |
| 6902881 | Compounds and methods for regulating cell differentiation The present invention makes available methods and reagents for inhibiting cell growth or promoting cell differentiation comprising contacting the cell with a differeguline in a sufficient amount to inhibit cell proliferation or promote cell differentiation. ... | 06/07/2005 |
| 6903125 | Tetrahydro-2H-thiopyran-4-carboxamide derivative A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) vi... | 06/07/2005 |
