Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8124629 | Naphthylacetic acids The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addi... | 02/28/2012 |
| 8119667 | Carbonates of fenicol antibiotics Novel fenicol compounds having useful properties as antibiotic prodrugs, are provided, together with methods of making and using these new compounds. ... | 02/21/2012 |
| 7786148 | Fungicidal composition comprising a pyridylethylbenzamide derivative and a compound capable of inhibiting the transport of electrons of the respiratory chain in phytopathogenic fungal organisms A composition comprising at least a pyridylethylbenzamide derivative of general formula (I) (a) and a compound capable of inhibiting the transport of electrons of the respiratory chain in phytopathogenic fungal organisms (b) in a (a)/(b) weight ratio of from 0.01 to... | 08/31/2010 |
| 7776892 | Fungicidal composition comprising a pyridylethylbenzamide derivative and a compound capable of inhibiting the spores germination or mycelium growth by acting on different metabolic routes A composition comprising at least a pyridylethylbenzamide derivative of general formula (I)(a) and a compound capable of inhibiting the spores germination or mycelium growth by acting on different metabolic routes (b) in a (a)/(b) weight ratio of from 0.01 to 20. | 08/17/2010 |
| 7737164 | Cyanopyridine antibacterial agents The present invention relates generally to compounds providing antibacterial therapeutic agents and preparations, and related methods of using and making antibacterial compounds. Antibacterial compounds of the present invention include chalcone, alkylpyrimidine, ami... | 06/15/2010 |
| 7700632 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activator The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts... | 04/20/2010 |
| 7504421 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably select... | 03/17/2009 |
| 7485653 | 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease The present invention provides certain substituted 1,4-dihydropyridine compounds, including pure enantiomeric forms and pharmaceutical formulations thereof. These compounds provide for elevation of α-MyHC protein levels and α-MyHC mRNA levels, and most frequently ... | 02/03/2009 |
| 7435743 | Pyridine derivatives Pyrimidine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy,... | 10/14/2008 |
| 7414055 | Inhibitors of Akt activity The present invention is directed to compounds which contain a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this inven... | 08/19/2008 |
| 7410986 | 4-6-diphenyl pyridine derivatives as antiinflammatory agents 4-aryl pyrimidine compounds of general formula and salts thereof: wherein X is CH or N; R1 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is hydrogen or hydroxy; R3 is hydrogen, C1-6 alkyl, etc.; R4 is hydrogen, hydroxy, halogen, amino, etc.; R5 is hydroxy,... | 08/12/2008 |
| 7320993 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, ... | 01/22/2008 |
| 7314871 | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors, for treatment of hypertension The application claims a method for treating hypertension by administering an effective amount of a compound of the formula (I) wherein the variable groups are as defined in the specification and claims. These 2-... | 01/01/2008 |
| 7302330 | Torque converter clutch dynamic control A method of dynamically controlling pressure to a torque converter clutch (TCC) of a torque converter coupled to a transmission is provided. The method includes: monitoring throttle position; monitoring engine speed; controlling pressure to the torque converter clut... | 11/27/2007 |
| 7276528 | Compounds for the inhibition of nitric oxide synthase There are provided novel compounds of formula (I) wherein A, R1, R3, R4, R5, T, U, V, W, X and Y are as defined in the specification, and pharmaceutically acceptable sa... | 10/02/2007 |
| 7262209 | Carbonyloxy-cyanomethyl compounds as antiparasitic agents The invention relates to compounds of the general formula wherein Ar1, Ar2, R4, R5, R6, R7, R8, W, X, a and b have the significances gi... | 08/28/2007 |
| 7253284 | Chemical compounds Compounds of the formula I, Wherein X is N, n is 1 and R2and R3 together form a ring, R, R1 and R4 are as defined in the specifications. ... | 08/07/2007 |
| 7148243 | Antivirals Compounds of the formula I: wherein Rx is cyano or bromo; R1 is halo; R2 is C114 C3 alkyl, and pharmaceutica... | 12/12/2006 |
| 7148346 | Purification process This invention provides a process for purifying a cyclosporin, e.g. cyclosporin A, or a macrolide, to a high degree of purity on a large scale. In another aspect this invention provides a bulk quantity of cyclosporin A with an impurity level of less than about 0.7%,... | 12/12/2006 |
| 7141590 | Pharmaceutical uses and synthesis of nicotinanilide-N-oxides Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies. ... | 11/28/2006 |
| 7135487 | Sulphonamide derivatives The present invention relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them. ... | 11/14/2006 |
| 7135486 | Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof This application relates to compounds of formula (I), wherein R1, R2, R3, and R4 are defined as recited in the claims, or a tautomer, salt, hyd... | 11/14/2006 |
| 7129255 | Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor This application relates to compounds of the formula wherein the groups R1–R6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and t... | 10/31/2006 |
| 7125880 | Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 an... | 10/24/2006 |
| 7122540 | 2-Phenyl substituted imidazotriazinones as phosphodiesterase inhibitors The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizi... | 10/17/2006 |
| 7119109 | Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase There are provided novel compounds of formula (I) wherein R1, R2, R3, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof; toget... | 10/10/2006 |
| 7109218 | Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same Compounds of the formula (I) a process for their preparation and their use as medicaments are described. ... | 09/19/2006 |
| 7087238 | Sheet-like packs A sheet-like pack effective for prevention and improvement of small wrinkles on skin, comprising a water soluble high molecular weight compound, water and ubiquinone 10 as an active ingredient, which are contained in a base. ... | 08/08/2006 |
| 7084138 | Active ingredient combinations with insecticidal and acaricidal properties The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the gro... | 08/01/2006 |
| 7041670 | Florfenicol-type antibiotics The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such... | 05/09/2006 |
| 7037927 | Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor The present invention relates to compounds of formula (I) that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity. ... | 05/02/2006 |
| 7015237 | Pyridine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 independently are hydrogen, halo, hydrox... | 03/21/2006 |
| 6998415 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. ... | 02/14/2006 |
| 6984649 | Pyridine derivatives Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 ... | 01/10/2006 |
| 6979695 | Compounds capable of activating cholinergic receptors The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via admini... | 12/27/2005 |
| 6972292 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ... | 12/06/2005 |
| 6958346 | 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of ... | 10/25/2005 |
| 6956043 | Pharmaceutical compositions comprising 33-epi-chloro-33-desoxy-ascomycin solid dispersions A pharmaceutical composition in the form of a solid dispersion comprising a macrolide, e.g. a rapamycin or an ascomycin, and a carrier medium. ... | 10/18/2005 |
| 6949556 | Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents The present invention relates to compounds of general formula (I), wherein R1-R4 have the meanings given in the specification, A is CH2, CHOH or CH—(C1-C3-alkyl), B and C a... | 09/27/2005 |
| 6946479 | N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones Compounds of Formula (I) are effective in the treatment of a microbial infection. ... | 09/20/2005 |
