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| Number | Title | Issue Date |
| 8188123 | (Pyrrolidin-2-yl)phenyl derivatives The invention relates to (pyrrolidin-2-yl)phenyl derivatives having the general Formula I wherein R1 is (C1-4)alkyl, halo(C1-4)alkyl, (C1-4)alkyloxy, or halo(C1-4)alkyl... | 05/29/2012 |
| 8188122 | Insecticidal aryl pyrrolidines The present invention provides novel aryl pyrrolidines having an excellent insecticidal action as insecticides. Aryl pyrrolidines represented by the formula (I) and use thereof as insecticide. ... | 05/29/2012 |
| 8173683 | Methods for treating cognitive disorders Disclosed herein are methods of treating a patient suffering a cognitive disorder. ... | 05/08/2012 |
| 8173682 | Substituted pyridones as inhibitors of poly(ADP-ribose) polymerase (PARP) The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates t... | 05/08/2012 |
| 8168659 | 1, 5-diphenyl-3-benzylamino-1, 5-dihydropyrrolidin-2-one as CB1 receptor modulators Compounds and pharmaceutical compositions comprising compounds of the Formula as CB1 receptor inverse agonists useful for reducing body weight in mammals, treating cognitive impairment associated with schizophren... | 05/01/2012 |
| 8163780 | Nicotine receptor agonists in stem cell and progenitor cell recruitment The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for ... | 04/24/2012 |
| 8158658 | Heteroaromatic selective inhibitors of neuronal nitric oxide synthase Compounds selectively inhibiting neuronal nitric oxide synthase (nNos), such compounds of a formula wherein the variables are defined, herein. ... | 04/17/2012 |
| 8153666 | Compounds having analgesic and/or immunostimulant activity The compounds shown by their structural formulas in the specification have analgesic and or immunostimulant activity in mammals. ... | 04/10/2012 |
| 8071630 | Treatment of effect of chemicals with their ultradilute stereoisomers A method of treating an effect of a chemical agent, which agent is characterized by one or more chiral centres, by administering a dilution or an ultra-high dilution or potentised preparation of a stereoisomer of said chemical agent. ... | 12/06/2011 |
| 8067443 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or trea... | 11/29/2011 |
| 8063078 | Urea-compounds active as vanilloid receptor antagonists for the treatment of pain Certain compounds of formula (I), or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein R1, R2, P, P′, n, p, q, r and s are as defined in the specification, a process for prepa... | 11/22/2011 |
| 8013000 | 3-heteroaryl-3-hydroxy-2-amino-propyl amines and related compounds having analgesic and/or immuno stimlant activity Compounds of the formula where the variables have the meaning defined in the specification have analgesic and/or immunostimulant effect in mammals. ... | 09/06/2011 |
| 7998985 | 1,5-diphenyl-3-pyridinylamino-1,5-dihydropyrrolidin-2-one as CB1 receptor modulator Compound and pharmaceutical compositions comprising the compounds of the Formula or a pharmaceutically acceptable salt thereof, as a CB1 receptor inverse agonist, useful for reducing body weight in mammals, treat... | 08/16/2011 |
| 7951826 | Pyrrolidine derivatives as histamine H3 receptor antagonists The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods and intermediates for preparing such compounds. In another embodim... | 05/31/2011 |
| 7943642 | Insecticidal N,N-di(heteroarylalkyl)amine derivatives Certain novel N,N-di(heteroarylalkyl)amine derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula (I): wherein Ar Ar1, a, b, c, R, Rd, Re, Rf, Rg, Rh | 05/17/2011 |
| 7858648 | Non-covalent complexes comprising carbon nanotubes The present invention relates to the use of a carbon nanotube comprising positive and/or negative charges, the charges being carried by at least one charge-carrying group, the charge carrying group being covalently bound to the surface of the carbon nanotube, for th... | 12/28/2010 |
| 7842707 | Peptidase inhibitors The present invention relates to a series of novel compounds having the formula (I) wherein: X is NR3 or O; n is 1 or 2; A is a bicyclic carbocycle and R1 and R2 are as described herein. The compounds are useful as DPP-IV inhibitors, such as for the treat... | 11/30/2010 |
| 7838539 | Nicotine receptor agonists in stem cell and progenitor cell recruitment The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for ... | 11/23/2010 |
| 7820699 | Cyclic amines The invention is concerned with cyclic amines of formula (I) wherein X1 to X3, Y1 to Y3, R1′, R1″ and n are as defined in the description and in the clai... | 10/26/2010 |
| 7776891 | VLA-4 antagonists Compounds of Formula (I) are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the trea... | 08/17/2010 |
| 7767698 | Formulation and use thereof A liquid pharmaceutical formulation comprising nicotine in any form for administration essentially to the lungs being acidified and/or alkalized by buffering and/or pH regulation providing for a tmax of nicotine in arterial blood of a subject within a sho... | 08/03/2010 |
| 7767699 | Therapeutic agents useful for treating pain The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical composit... | 08/03/2010 |
| 7718677 | Methods and compositions for reduction of side effects of therapeutic treatments The invention provides compositions and methods utilizing a nicotinic receptor modulator, e.g., to reduce or eliminate a side effect associated with dopaminergic agent treatment. In some embodiments, the invention provides compositions and methods utilizing a combin... | 05/18/2010 |
| 7714001 | Arylvinylazacycloalkane compounds and methods of preparation and use thereof Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or trea... | 05/11/2010 |
| 7714000 | Substituted pyrrolidinones and their use as medicaments The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R1 to R9 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the ... | 05/11/2010 |
| 7696234 | Histamine H3 receptor agents, preparation and therapeutic uses The present invention discloses novel compounds of Formula I or pharmaceutically acceptable salts thereof which have histamine-H3 receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention d... | 04/13/2010 |
| 7671073 | Cyclohexylalanine derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes The present invention is directed to novel cyclohexylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme i... | 03/02/2010 |
| 7598274 | Pyrrole derivatives Compounds of the formula (I), in which X, Y, Z and Ar have the meanings indicated in claim 1, are inhibitors of Raf kinase and can be employed, inter alia, for the treatment of tumours ... | 10/06/2009 |
| 7598275 | Nicotine in therapeutic angiogenesis and vasculogenesis Methods are provided for induction of angiogenesis by administration of nicotine or other nicotine receptor agonist. Induction of angiogenesis by the methods of the invention can be used in therapeutic angiogenesis in, for example, treatment of ischemic syndromes su... | 10/06/2009 |
| 7550487 | Pyrrolidine-3,4-dicarboxamide derivatives The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of formula (I) wherein R1 to R9 and X are as defined in the description and in the claims, as well as physiologically acc... | 06/23/2009 |
| 7547712 | Methods for decreasing the toxic effects of nicotine on fetuses in pregnant women The present invention relates methods for reducing the adverse effects of nicotine. This application describes the use of nicotine carrier conjugates in decreasing the toxic effects of nicotine on a fetus. ... | 06/16/2009 |
| 7456202 | Marked maleimide compounds, method for preparing same and use thereof for marking macromolecules Fluorine-18-labelled maleimide compounds of general formula (I): in which: m represents an integer from 0 to 10; n represents an integer from 1 to 10; Y r... | 11/25/2008 |
| 7452911 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relat... | 11/18/2008 |
| 7442702 | Prostaglandin agonists This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatmen... | 10/28/2008 |
| 7435749 | Beverage treated with nicotine The present application is directed to a method for preparing a solution containing processed nicotine and beverages made according to such method. The beverage produced according to this method does not have the discernible taste, smell or appearance of nicotine. | 10/14/2008 |
| 7432288 | Pyrrole-2,5-dione derivatives as Liver X receptor modulators The present invention relates to certain novel compounds of the Formula I to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR)α(NR1H3) and/or β(... | 10/07/2008 |
| 7414055 | Inhibitors of Akt activity The present invention is directed to compounds which contain a substituted pyridine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this inven... | 08/19/2008 |
| 7407974 | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thro... | 08/05/2008 |
| 7407972 | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thro... | 08/05/2008 |
| 7402606 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle ... | 07/22/2008 |
