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Class 514/341 - The additional hetero ring consists of two nitrogens and three carbons


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the additional hetero ring consists
No. of patents: 1063
Last issue date: 05/21/2013


1                      
NumberTitleIssue Date
84455191-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
Provided are 1-aryl-5-alkyl pyrazole compounds, of formula (I): wherein: R1 is hydrogen, cyano, halogen, R8, formyl, —C(O)R8, —C(O)OR8, —C(O)NR9R10, or...
05/21/2013
84360242-pyridone compounds
The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R7, L, X and Y are as defined in the specification; together with processes and inter...
05/07/2013
84101462-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
2-pyridyl substituted imidazoles of the formula (I) as shown in claim 1, are provided, which are useful in the treatment of diseases mediated by ALK5 or ALK4 inhibitors or both. ...
04/02/2013
8394838Process for producing amide compound
There is provided a process for producing an amide compound having an excellent harmful arthropod-controlling activity and represented by the formula (III): wherein R1, R2 and R3 independently represent a C1-C6 ...
03/12/2013
8377970Modulators of calcium release-activated calcium channel
Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell ...
02/19/2013
8354436IL17 and IFN-gamma inhibition for the treatment of autoimmune inflammation
The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents. ...
01/15/2013
8349873Factor XA inhibitors
The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical...
01/08/2013
8349874Cyclohexane derivative and pharmaceutical use thereof
A method relieves both nociceptive pain and neuropathic pain and has fewer side effects. The compound includes cyclohexane derivatives represented by the following compound, or pharmaceutically acceptable salts thereof or prodrugs thereof.
01/08/2013
8329733Composition for noxious organisms-controlling agent and method for using the same
The present invention relates to a composition for noxious organisms-controlling agent having a synergistic effect and a method for using said composition, which comprises, as active ingredients thereof, one or more compounds selected from the phthalamide derivative...
12/11/2012
83187772-pyridinylethylcarboxamide derivatives and their use as fungicides
The invention discloses a compound of general formula (I) and a process for preparing this compound. The invention discloses a fungicidal composition comprising a compound of general formula (I) and a method for treating pl...
11/27/2012
8288419Aminopyrazole derivatives
The invention relates to aminopyrazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. ...
10/16/2012
8273771Ischemic disorder or disease inhibitors
The invention relates to the use of at least on inhibitor selected from the group consisting of raf-, protein kinase C (PKC)-, MEK1/2-, or ERK1/2-inhibitors, for the manufacturing of a medicament to be administrated from 1 up to 12 hours after initiation of an ische...
09/25/2012
8236823Multi-cyclic compounds and methods of use
The present invention relates to compounds of Formulas I and II, wherein B1, B2, B3, B4, C1, C2, ring D, L1, L2 and R1-4 are...
08/07/2012
8236824N-(pyrazole-3-yl)-benzamide derivatives as glucokinase activators
Novel heterocyclic compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, Alk and D have the meanings indicated in claim 1,
08/07/2012
8222280Ether compounds with nitrogen-containing 5-member heterocycle and uses thereof
The invention relates to ether compounds with nitrogen-containing 5-member heterocycle, represented by formula (I): The groups are as defined as specification. The compounds of the present invention have broad-spectrum...
07/17/2012
8173681Method for the protection of materials
The present invention relates to the use of the compound A) 4-(2,2-difluoro-1,3-benzodioxol-4-yl)pyrrole-3-carbonitrile(fludioxonil) as a microbicide for the protection of engineering or industrial materials, to mixtures containing such compound, and to the use of s...
05/08/2012
8143293Kinase inhibitors useful for the treatment of myleoprolific diseases and other proliferative diseases
Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant, melanomas, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kid...
03/27/2012
8143292N-Thio-anthranilamid compounds and their use as pesticides
N-Thio-anthranilamid compounds of formula (I) wherein A is a group selected from A1 and A2 wherein the variables and the indices are as defined per the descr...
03/27/2012
81432942-sulfanyl-substituted imidazole derivatives and their use as cytokine inhibitors
The invention relates to 2-thio-substituted imidazole derivatives of the Formula I, and to methods of use thereof. ...
03/27/2012
8119665Aryl imidazoles and related compounds as C5a receptor modulators
The invention provides packaged pharmaceutical preparations of Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the variables are defined herein. Such compounds are liga...
02/21/2012
8084474Insecticides
Compounds of formula (I) wherein the substituents are as defined in claim (1), and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I) can be used as agrochemical active ingredients and can be prepare...
12/27/2011
80716292-pyridinylcycloalkylcarboxamide derivatives as fungicides
A compound of general formula (I): A process for preparing this compound. A compound of general formula (II): A fungicide composition comprising a compound of general formula (I...
12/06/2011
8063076Solid forms of 2-Chloro-4-[1-(4-fluoro-phenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]-pyridine
The present invention relates to the mono-sulfate salt, crystalline forms A and B of the mono-sulfate salt, an amorphous form of the mono-sulfate salt, hemi-sulfate salts, and a crystalline form A of the hemi-sulfate salt of the compound 2-chloro-4-[1-(4-fluoro-phen...
11/22/2011
8063077Factor Xa inhibitors
The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical...
11/22/2011
8026260Histone deacetylase inhibitors with aryl-pyrazolyl-motifs
The present invention relates to a novel class of histone deacetylase inhibitors with aryl-pyrazolyl motifs. The compounds of this invention can be used to treat cancer. The compounds of this invention are suitable for use in selectively inducing terminal differenti...
09/27/2011
8017632Selective insecticides based on haloalkylnicotinic acid derivatives, anthranilic acid diamides, or phthalic acid diamides and safeners
The present invention relates to the use of selective insecticidal compositions, characterized by an effective amount of an active compound combination comprising (a) (1) at least one haloalkylnicotinic acid derivative of the formula (I) ...
09/13/2011
7994200Cycloalkane-substituted pyrazoline derivatives, their preparation and use as medicaments
The present invention relates to Cycloalkane-substituted substituted pyrazoline compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and a...
08/09/2011
7994201Anthranilamide compounds, process for their production and pesticides containing them
Anthranilamide compounds, a process for their production, and pesticides containing these compounds as active ingredients. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any w...
08/09/2011
7968573Hydrazide compound and pesticidal use of the same
A hydrazide compound represented by the formula (1): (wherein R1, R2, R3, R4, A1, A2, J, Q and n are defined in the specification) has excellent pesticidal a...
06/28/2011
7964620Imidazole derivatives
The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3, R4, X, Y and R are described hereinabove, or a pharmaceutically acceptable salt thereof. Th...
06/21/2011
7960413Pyrazole compounds
Compounds of the formula (I) and salts and solvates thereof, in which X, R1, R2, R3, R4, R5 and R6 have the meanings indicated in Claim 1, are suitable as ligands of 5 HT receptors.
06/14/2011
7939550Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same
Provided are aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same. Since the aminopyrazole derivatives of the present invention can reduce an ischemic cell death signif...
05/10/2011
7902231Anthropodicidal anthranilamides
This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts wherein R1, R2, R3, R4a, R4b and R
03/08/2011
7902232Substituted arylpyrazoles
This invention relates to a combination product comprising a range of 1-aryl-4 -cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents. ...
03/08/2011
7875634Cyano anthranilamide insecticides
This invention provides compounds of Formula 1, N-oxides and suitable salts thereof wherein R1 is Me, Cl, Br or F; R2 is F, Cl, Br, C1-C
01/25/2011
7868025Pesticide
The present invention provides a composition comprising synergistic amounts of a compound of the formula (I) wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active compound as defined herein. The...
01/11/2011
7863299Triazolyl derivatives of azabicyclo [3.1.0] hexane as dopamine D3 receptor modulators
The present invention relates to novel compounds of formula (IC) or a salt thereof: wherein: p is an integer ranging from 0 to 4; R1 is independently selected from a group consisting of:...
01/04/2011
7829586Aryl-substituted nitrogen-containing heterocyclic compounds
Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating...
11/09/2010
7807698Azabicyclo[3.1.0]hexane derivatives as modulators of the dopamine D3 receptor
The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein G is selected from a group consisting of: phenyl, pyridyl, benzothiaz...
10/05/2010
7803819DPP IV inhibitors
The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for...
09/28/2010
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