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| Number | Title | Issue Date |
| 8188121 | Substituted pyridines as antiparasitic AZA teraryl compounds Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. The compounds include those of Formula (III): wherein one of A1, Y1, and Z1 is ... | 05/29/2012 |
| 8183264 | Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same The present invention provides an antifungal agent that has excellent antifungal action, and is also excellent in terms of its properties, safety, and metabolic stability. The present invention discloses a compound represented by the following formula I or a salt th... | 05/22/2012 |
| 8183265 | 2-adamantyl-butyramide derivatives as selective 11β-HSD1 inhibitors The present invention relates to 2-adamantyl-butyramide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diab... | 05/22/2012 |
| 8178562 | Pyridine derivatives The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents. ... | 05/15/2012 |
| 8158657 | Heterocycles substituted pyridine derivatives and antifungal agent containing thereof An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represe... | 04/17/2012 |
| 8084473 | Heterocyclic compounds with affinity to muscarinic receptors The present invention relates to heterocyclic compounds of the formula (I) or a pharmaceutically acceptable salt, a solvate or hydrate thereof. ... | 12/27/2011 |
| 8063075 | Pyrrolidine ether derivatives as NK3 receptor antagonists The present invention relates to compounds of formula I wherein R1, R2, R3, R′, Ar, m, n, and o are as defined herein. The invention also relates to pharmaceutical compositions containing ... | 11/22/2011 |
| 8058292 | Therapeutic agents useful for treating pain The invention provides a compound of formula (I): (where R1, Q, A and R2 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Pyridine-alkynyl Compound”); pharmaceutical composit... | 11/15/2011 |
| 8017631 | Oxadiazole derivatives and their medical use This invention relates to novel oxadiazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse... | 09/13/2011 |
| 7998984 | 2-pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X and W are as defined in the specification and optical isomers, racemates and t... | 08/16/2011 |
| 7998983 | Substituted isoxazoles as fungicides The present invention provides compounds of formula I: along with methods of making the same, compositions thereof, and methods of use thereof, particularly methods of use as fungicides. ... | 08/16/2011 |
| 7968571 | 2,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's Disease The present invention is directed to 2,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The in... | 06/28/2011 |
| 7968572 | Nitrogen-containing heterocyclic compound and pharmaceutical application thereof It is intended to provide a compound represented by the formula (I): wherein all the symbols are as defined in the description; which has a p38 MAP kinase inhibitory activity, a sal... | 06/28/2011 |
| 7951825 | Hetero compound To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity. | 05/31/2011 |
| 7947715 | Isoxazoline compound and pesticide There is provided a novel pesticide, particularly an insecticide or an acaricide. A substituted isoxazoline compound of formula (1) or a salt thereof: wherein A1, A2 and A3 independently of ... | 05/24/2011 |
| 7915297 | Isoxazole derivatives and use thereof Disclosed herein are isoxazole derivatives and uses thereof. Serving as agonists of Wnt, the isoxazole derivatives activate Wnt/β-catenin signaling and thus can be used in the treatment and prevention of diseases related to the signal transduction. Also, pharmaceut... | 03/29/2011 |
| 7872031 | c-MET protein kinase inhibitors The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods o... | 01/18/2011 |
| 7858646 | Potentiators of glutamate receptors The present invention provides compounds of formula (I); pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof. ... | 12/28/2010 |
| 7816380 | 1-hydroxycycloalkanecarboxamide derivatives α-Hydroxycycloalkanecarboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein formula (a) is a single or double bond; R1, R2 and R3 are each independently selected from H, halogen and OH; or R | 10/19/2010 |
| 7816379 | Oxazolidinone derivatives The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad... | 10/19/2010 |
| 7795281 | Optically active dihydropyridine derivative The optically active compound (R)-2-amino-1,4-dihydro-6-methyl-4-(3 -nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) ester 5 -isopropyl ester or a pharmacologically acceptable salt thereof, and a method using the compound or its salt to ... | 09/14/2010 |
| 7786147 | Analogs of choline for neuroprotection and cognitive enhancement in neurodegenerative disorders The present invention relates to novel analogs of choline and methods of use or treatment of neurodegenerative disorders and/or conditions such as Parkinson's disease, Huntington disease, Alzheimer's disease and related disorders such as amyotrophic lateral sclerosi... | 08/31/2010 |
| 7781460 | Substituted indazoles as inhibitors of phosphodiesterase type-IV The present invention relates to isoxazoline derivatives of structure Ia, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, c... | 08/24/2010 |
| 7754742 | Imidazole carboxamides The present invention provides certain imidazole carboxamide derivatives, pharmaceutical compositions thereof, methods of using the same and processes for preparing the same. ... | 07/13/2010 |
| 7754741 | Pyridine derivatives as fungicidal compounds Compound of general formula (I): Process for preparing this compound. Novel intermediate of general formula (E): for the preparation of compound of general formula (I) Fungicidal composition comprising a compound of general formula (I). Method for treating plants by... | 07/13/2010 |
| 7732466 | Substituted thiophene carboxamides, process for their preparation and their use as medicaments The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula wherein A, and R1 to R8c are defined as in claim 1, the tautomers, the enantiomers, the dia... | 06/08/2010 |
| 7723362 | Pesticidal heterocyclic dihaloallyl compounds The invention relates to compounds of formula wherein Het, A1, A2, A3, A4, D, W, T, Q, Y, X1, X2, R1, R | 05/25/2010 |
| 7718676 | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and ani... | 05/18/2010 |
| 7662839 | EP2 receptor agonists A compound of formula (I): or a salt, or chemically protected form thereof, wherein: R5 is an optionally substituted phenyl; A is | 02/16/2010 |
| 7649004 | Pyridine derivatives The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such c... | 01/19/2010 |
| 7642273 | Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure ... | 01/05/2010 |
| 7605172 | Thiazolo-naphthyl acids The present invention relates to thiazolo-naphthyl acids of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders. ... | 10/20/2009 |
| 7605171 | (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists The present invention encompasses compounds of Formula I: as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory... | 10/20/2009 |
| 7601742 | Pyrrolidones with anti-HIV activity The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in ... | 10/13/2009 |
| 7595332 | Amides that inhibit vanilloid receptor subtype 1 (VR1) The present invention relates to compounds of formula (I) that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity. ... | 09/29/2009 |
| 7585881 | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.... | 09/08/2009 |
| 7585882 | Phosphodiesterase 4 inhibitors Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R1, R2, and R3 | 09/08/2009 |
| 7585880 | Phenylpropanoic acid derivatives The present invention provides a novel compound having a GPR40 receptor function modulating action, which is useful as an insulin secretagogue, a drug for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I) ... | 09/08/2009 |
| 7582659 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast ... | 09/01/2009 |
| 7566730 | Substituted aminoethers for the treatment of Alzheimer's disease The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characteriz... | 07/28/2009 |
