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| Number | Title | Issue Date |
| 8173610 | Derivatives of epirubicin, their medicinal application and pharmaceuticaly acceptable forms of drugs The present invention relates to novel derivatives of epirubicin, pharmaceutical composition comprising these derivatives, and uses of epirubicin and its derivative for treating HCV. ... | 05/08/2012 |
| 8148339 | Method of reducing cardiac levels of doxorubicin when given as orotate salt This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate salts. More particularly, it concerns orotate salts of the anthracyclines, doxorubicin and daunorubicin, tha... | 04/03/2012 |
| 8148338 | Doxorubicin formulations for anti-cancer use Doxorubicin block copolymer formulations for use in preparing injectable compositions for treating cancer patients which contain lactose for solubilizing the doxorubicin and block copolymers in said formulations and methyl paraben for stabilizing these formulations,... | 04/03/2012 |
| 8030283 | Stabilization of amrubicin hydrochloride A stabilized amrubicin hydrochloride composition which comprises 3 to 8 wt. % water and 92 to 97 wt. % amrubicin hydrochloride; and a method of storing amrubicin hydrochloride. ... | 10/04/2011 |
| 7994141 | Compositions comprising compounds of natural origin for damaged skin The present invention relates to a skin-protecting composition for the damaged skin, comprising glycyrrhizin, quercetin, rosmarinic acid, madecassic acid, chamazulene, bicalein and emodin. The composition of the present invention has all of excellent antioxidant, an... | 08/09/2011 |
| 7781412 | Biphenyl inhibitors of carbonyl reductase Compositions of matter and methods of treating cancer patients may prevent or limit cardiotoxicity during or after chemotherapy, and/or may prevent or lower resistance to anthracycline drugs, both of which are believed to be caused by the human enzyme carbonyl reduc... | 08/24/2010 |
| 7737123 | Multidrug resistant anticancer anthracyclines Daunorubicin (“DNR”) compounds synthesized with uncommon sugars exhibit enhanced effectiveness in treating various drug-resistant cancers. ... | 06/15/2010 |
| 7727968 | Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome Methods of treatment and pharmaceutical combinations are provided for the treatment of acute leukemia, such as acute myelogenous leukemia, and myelodysplastic syndrome. The methods of treatment and pharmaceutical combinations employ an anti-CD33 cytotoxic conjugate ... | 06/01/2010 |
| 7727967 | Cyanooxime inhibitors of carbonyl reductase and methods of using said inhibitors in treatments involving anthracyclines Compositions of matter for treating cancer patients are used to prevent or limit cardiotoxicity during or after treatment with anthracycline drugs, and to prevent or lower resistance to anthracycline drugs, both of which are believed to be caused by the human enzyme... | 06/01/2010 |
| 7659257 | Medicament for treating lung cancer Lung cancer can be treated effectively by combination of amrubicin or a pharmaceutically acceptable salt thereof with cisplatin. ... | 02/09/2010 |
| 7557091 | HKI10311129, novel antibiotic, method for producing the same and the use thereof The invention relates to the novel antibiotic HKI10311129 which has a molecular weight of 1113 and the summation formula C56H75NO22. The invention also relates to a method for producing said antibiotic using the microorganism Stre... | 07/07/2009 |
| 7557090 | Anthracycline antibiotics and methods of treating cancer using the same The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also disclose... | 07/07/2009 |
| 7541342 | Use of PKC-activating compounds as cardioprotectants and as apoptosis-inducing anti-tumor agents Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-δ to the mitochondria and the phosphorylation of mitochondrial phospholipid scramblase 3. The compounds also provide cardioprote... | 06/02/2009 |
| 7514413 | In-vivo energy depleting strategies for killing drug-resistant cancer cells This invention also provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to, or close to, at least 15% of normal in cancer cells wherein at least o... | 04/07/2009 |
| 7511023 | Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer drug-chitosan complex forming self-aggregates in aqueous media composed o... | 03/31/2009 |
| 7470672 | Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives This invention is in the field of chemical restructuring of pharmaceutical agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it concerns orotate derivatives of the anthracyclines, doxorubicin and dauno... | 12/30/2008 |
| 7462601 | Ameliorant for chemical treatment of cancer An ameliorating agent for cancer chemotherapy is disclosed, which comprises a chromanol glycoside represented by the following general formula (1) (wherein R1, R2, R3, and R4, whi... | 12/09/2008 |
| 7371714 | Chemical agent decontamination composition comprising a perfluorinated alkyl bromide A composition and methods of use for the decontamination of chemical agents, including chemical warfare agents. The decontamination composition is nontoxic, nonflammable and non-corrosive and includes an effective amount of a perfluorinated alkyl bromide or reactive... | 05/13/2008 |
| 7368565 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents The present invention discloses a one-step process for the production of cytotoxic conjugates of maytansinoids and cell binding agents. Maytansinoids having a disulfide linker that bears a reactive moiety are linked to cell binding agents, such as antibodies, withou... | 05/06/2008 |
| 7368102 | Pulmonary delivery of aminoglycosides The present invention is directed to the administration of aminoglycosides. In particular, the present invention is directed to compositions and methods for the pulmonary administration of aminoglycosides. According to a preferred embodiment, compositions and method... | 05/06/2008 |
| 7345023 | Treatment of hyperproliferative conditions of body surfaces The present invention relates to pharmaceutical formulations comprising an anthracycline and the uses thereof for treatment of clinical conditions of body surfaces such as skin and mucosal membranes, wherein abnormal cell differentiation and/or hyperproliferation is... | 03/18/2008 |
| 7332200 | Permeabilizing biofilms Methods for permeabilizing biofilms using stress waves are described. The methods involve applying one or more stress waves to a biofilm, e.g., on a surface of a device or food item, or on a tissue surface in a patient, and then inducing stress waves to create trans... | 02/19/2008 |
| 7314862 | Antitumor agent The present invention relates to an antitumor agent containing a histone deacetylase inhibitor and a topoisomerase II inhibitor in combination. This combination has been found to exhibit a synergistic anticancer or antitumor effect compared to administration of eith... | 01/01/2008 |
| 7311912 | Epithelial tissue targeting agent Targeting molecules for use in delivering biological agents to epithelial tissue are disclosed. Upon delivery, the biological agent(s) may remain within an epithelial cell or may undergo transepithelial transport via transcytosis. The targeting molecules may be used... | 12/25/2007 |
| 7309782 | Crystal forms of azithromycin The invention relates to novel crystal forms of azithromycin, an antibiotic useful in the treatment of infections. ... | 12/18/2007 |
| 7304037 | Cytostatic conjugates with integrin ligands The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to αvβ3 integrin antagonists via preferred linking units which can be selectively cleaved by elastase, i.e. by an enzyme which can especial... | 12/04/2007 |
| 7303755 | Pharmaceutical compositions with antibiotic activity The use of certain salts and aminoacids as stabilizer of the antibiotic Fosfomycin Tromethamol and pharmaceutical compositions containing them, is described. ... | 12/04/2007 |
| 7291713 | Branched polyalkylene glycols The present invention provides a branched polyalkylene glycol wherein three or more single-chain polyalkylene glycols and a group having reactivity with an amino acid side chain, the N-terminal amino group or the C-terminal carboxyl group in a polypeptide or a group... | 11/06/2007 |
| 7288534 | Sphingomyelin enhancement of tumor therapy Cytotoxic tumor therapy in a patient is enhanced by co-administration of sphingomyelin. The invention most likely enhances a tumor cell's ability to undergo ceramide-induced apoptosis by increasing the levels of sphingomyelin in all cellular compartments, thereby pr... | 10/30/2007 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7241456 | Formulations for topical delivery of bioactive substances and methods for their use The invention relates to topical delivery of bioactive agents. More particularly, the invention relates to anhydrous formulations for percutaneous absorption. The invention provides formulations that allow efficient topical delivery of high concentrations of bioacti... | 07/10/2007 |
| 7238366 | Submicron liposome suspensions obtained from preliposome lyophilizates This invention provides an aqueous/t-butanol solvent-system, facile reconstitute, submicron-reconsitiute preliposome-lyophilaye and method of its preparation and use. In one embodiment this entails a modified method for the preparation of a submicron and stab... | 07/03/2007 |
| 7229973 | pH-sensitive polymeric micelles for drug delivery Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the micro... | 06/12/2007 |
| 7217770 | Stable polymeric micelle-type drug composition and method for the preparation thereof A biocompatible stable composition containing a hydrophobic drug, such as paclitaxel. The composition, which forms a syringeable polymeric micellar solution in aqueous or body fluids, is a freeze-dried product comprising a hydrophobic drug, i.e. paclitaxel, and an a... | 05/15/2007 |
| 7205001 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 04/17/2007 |
| 7204996 | Method of cancer treatment This invention comprises a method of treating a subject having relapsed or refractory cancer such as leukemia with liposomal annamycin including the steps of (a) evaluating the subject to determine if the subject has relapsed or re... | 04/17/2007 |
| 7179492 | Traditional chinese pharmaceutical formulation for treatment of paradentosis, process for preparation and use thereof This invention involves a traditional Chinese medical preparation, its preparation and use. The present Chinese medicine that treats periodontitis is a pharmaceutically acceptable oral preparation containing fleece-flower, dried rehmanria, licorice, fresh-water turt... | 02/20/2007 |
| 7179493 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 02/20/2007 |
| 7163703 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 01/16/2007 |
| 7163702 | Process for isolating sea cucumber saponin Frondoside A, and immunomodulatory methods of use This present invention discloses use of a chloroform/solvent mixture extraction at different solvent-to-feed ratios, followed by evaporation and extraction with ethyl acetate/water; followed by chromatography of the water phase in Teflon or other non-polar resin and... | 01/16/2007 |
