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| Number | Title | Issue Date |
| 8163778 | Pyridines as FBPase inhibitors for treatment of diabetes Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof wherein the residues have the significance given in claim 1 and which can be used in the form of pharmaceutical compositions. | 04/24/2012 |
| 8158656 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors The present invention relates to 2-indolinone derivatives which are capable of inhibiting protein kinases and histone deacetylases. The compounds of this invention are therefore useful in treating diseases associated with abnormal protein kinase activities or abnorm... | 04/17/2012 |
| 8153664 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond,... | 04/10/2012 |
| 8143291 | Indole compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor biological activity The invention provides well-defined aryl and/or heteroaryl substituted indoles that are useful as sphingosine-1-phosphate agonists or antagonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation o... | 03/27/2012 |
| 8129417 | Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the specification. Th... | 03/06/2012 |
| 8030334 | Organic compounds The present invention provides novel organic compounds of Formula I: methods of use, and pharmaceutical compositions thereof. ... | 10/04/2011 |
| 8026259 | Indoles The present invention is concerned with novel indol-2-yl-carbonyl-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are usefu... | 09/27/2011 |
| 8017630 | Cyclohexylacetic acid compounds Novel cyclohexylacetic acid compounds corresponding to formula I: processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including thes... | 09/13/2011 |
| 7968570 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined... | 06/28/2011 |
| 7919512 | Compounds having CRTH2 antagonist activity Compounds of general formula (II) wherein W is chloro or fluoro; R1 is phenyl optionally substituted with one or more substituents, selected from halo, —CN, —C1-C6 al... | 04/05/2011 |
| 7868024 | Derivatives of N-(heteroaryl)-1-heteroaryl-1H-indole-2-carboxamides, preparation thereof and therapeutic use thereof The invention relates to compounds of formula (I): Wherein X1, X2, X3, X4, Y and W are as described herein. The invention also relates to a preparation method and to a therapeutic... | 01/11/2011 |
| 7851490 | Benzimidazole derivatives and their use for modulating the GABAreceptor complex This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders,... | 12/14/2010 |
| 7834037 | 5-lipoxygenase-activating protein (FLAP) inhibitors Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other co... | 11/16/2010 |
| 7812036 | Androgens The compounds of the subject invention have a structure according to formula I: wherein each of the substituents is given the definition as set forth in the specification and claims, or a salt or hydrate form thereof. ... | 10/12/2010 |
| 7795280 | Indoles useful in the treatment of androgen-receptor related diseases This invention provides non-steroidal compounds with affinity for the androgen receptor and utility for androgen-receptor related treatments, having a structure according to the formula or a salt or hydrate form thereof. | 09/14/2010 |
| 7790755 | Controlled release preparation A controlled release preparation wherein the release of active ingredient is controlled, which releases an active ingredient for an extended period of time by staying or slowly migrating in the gastrointestinal tract, is provided by means such as capsulating a table... | 09/07/2010 |
| 7786146 | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators This invention provides compounds of formula I where the dashed line represents an optional double bond; where R1 is phenyl, naphthyl, pyridyl, pyrimidyl, pyrrolyl, imidazolyl, pyrazyl, furyl, thienyl, ... | 08/31/2010 |
| 7754740 | 1-indole-3-carboxylic acid derivatives and their use as PPAR agonists Compounds of the formula (1): in which A, R1, R2 and R3 are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and t... | 07/13/2010 |
| 7750027 | Compounds having CRTH2 antagonist activity Compounds of general formula (I) wherein W is chloro or fluoro; R1 is phenyl optionally substituted with one or more substituents, selected from halo, —CN, —C1-C6 | 07/06/2010 |
| 7745467 | -(heteroaryl)-1-heteroarylalkyl-1-indole-2-carboxamide derivatives, preparation and therapeutic use thereof The invention concerns compounds of general formula (I), wherein n, X1, X2, X3, X4, Y and W are as defined herein. The invention also concerns a method for preparing said compound... | 06/29/2010 |
| 7705023 | Indoles useful in the treatment of inflammation There is provided a compound of formula: (I), wherein X, R1, R2, R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in ... | 04/27/2010 |
| 7705021 | Isoindolone compounds, compositions containing the same, and methods of use thereof for the treatment of viral infections related to the etiology of cancer Isoindolone derivatives, compositions containing the same, and methods of use thereof for the treatment or prophylaxis of viral infection are disclosed. ... | 04/27/2010 |
| 7705022 | IDO inhibitors and methods of use thereof Novel indoleamine 2,3-dioxygenase (IDO) inhibitors, compositions comprising the same, and methods of use thereof are disclosed. ... | 04/27/2010 |
| 7696231 | Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs) The present invention is related to the use of oxindole hydrazide derivatives of formula (I) for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose toleranc... | 04/13/2010 |
| 7642272 | Cannabinoid receptor ligands There are disclosed compounds of the formula I a pharmaceutically acceptable salt or solvate of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions con... | 01/05/2010 |
| 7615567 | Compounds and methods for promoting smoking cessation Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states. ... | 11/10/2009 |
| 7612099 | Vinylogous acid derivatives The invention is concerned with vinylogous acids derivatives of formula (I) wherein A and R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts there... | 11/03/2009 |
| 7582658 | Bicyclic compound A novel compound represented by the following formula (1) or a salt thereof: wherein symbol “A” represents a saturated heterocyclic group, a 5-membered heteroaromatic group having two heteroatoms in the ring, a group re... | 09/01/2009 |
| 7579365 | Indolyl-3-glyoxylic acid derivatives having antitumor action The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least o... | 08/25/2009 |
| 7557130 | Bicyclic heteroaromatic alanines Compounds of formula (1) are described: in which X is an —O— or —S— atom or —N(R2)— group and R1 is a group Ar1L2Ar2Alk- in which Ar1 is an optionally substituted aromatic or heteroaromati... | 07/07/2009 |
| 7534803 | Method of treating demyelinating diseases or conditions N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord... | 05/19/2009 |
| 7524871 | Thrombin inhibitors Novel thrombin inhibitors of the formula I (I)and pharmaceutically acceptable salts thereof are described wherein the substituents in the description have the specific meanings. The compounds are useful as thrombin inhibitors. ... | 04/28/2009 |
| 7488743 | Indolin-2-one pyridine derivatives, preparation and therapeutic use thereof The disclosure concerns indolin-2-one pyridine compounds of general formula (I): wherein R0, R1, R2, R3, R4, Z and B have the meanings given in the description, and pha... | 02/10/2009 |
| 7482368 | Triamide-substituted heterobicyclic compounds The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for prep... | 01/27/2009 |
| 7468380 | Nitrogen-containing aromatic derivatives A compound represented by the general formula: wherein X1 represents a nitrogen atom or a group represented by the formula —CR10═; X2 represents a nitrogen atom or a group represented by... | 12/23/2008 |
| 7452910 | Indolyl-3-glyoxylic acid derivatives having therapeutically valuable properties The invention relates to the use of N-substituted indole-3-glyoxylamides of the general Formula I: and to pharmaceutical compositions having antitumor action. ... | 11/18/2008 |
| 7442702 | Prostaglandin agonists This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatmen... | 10/28/2008 |
| 7435729 | Compounds and methods for modulation of estrogen receptors Compounds that modulate the estrogen receptor (ER) are disclosed, as well as pharmaceutical compositions containing the same. In a specific embodiment, the compounds are selective modulators for ER-β over ER-α. Methods are disclosed for modulating ER-β in cell an... | 10/14/2008 |
| RE40525 | Hepatitis C inhibitor tri-peptides A racemate diastereoisomer and optical isomer of a compound of formula (I): wherein B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally substituted wi... | 09/30/2008 |
| 7425553 | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases The present invention relates to novel Triheterocyclic Compounds, compositions comprising a Triheterocyclic Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a Triheterocyclic Compound. The compounds, co... | 09/16/2008 |
