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| Number | Title | Issue Date |
| 8129416 | Biaromatic compounds that modulate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular disea... | 03/06/2012 |
| 8114895 | Use of bipyridine compound ‘Caerulomycin A’ derivatives and analogs thereof as immunosuppressive agents The present invention relates to an isolated bioactive molecule Caerulomycin A, derivatives and analogs thereof as effective immunosuppressive agents. The immunosuppressive property of the compound is targeted in particular against the lymphocytes, CD4+ T... | 02/14/2012 |
| 8067441 | Use of collismycin and derivatives thereof as oxidative stress inhibitors The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment of oxidative stress-induced diseases or conditions, especially neurodegenera... | 11/29/2011 |
| 7998982 | Amide derivatives as TRPV1 antagonists The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, and R3, are defined in ... | 08/16/2011 |
| 7939549 | 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the... | 05/10/2011 |
| 7939548 | Certain chemical entities, compositions, and methods Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described. ... | 05/10/2011 |
| 7868023 | Thiophene sulfoximines, compositions thereof, and methods of treating complement-mediated diseases and conditions Disclosed are compounds for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade. The compounds are of Formula I or a solvate, hydrate, pharmaceutically acceptabl... | 01/11/2011 |
| 7803818 | Amorphous form of 1,2-dihydropyridine compound An amorphous form of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridine-2-one. ... | 09/28/2010 |
| 7465747 | Fluorescent label compounds It is intended to provide novel labeling reagents characterized by having a group capable of binding to a substance to be labeled (for example, a biological substance, a physiologically active substance, etc.), easily forming a complex together with a rare earth ion... | 12/16/2008 |
| 7435743 | Pyridine derivatives Pyrimidine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy,... | 10/14/2008 |
| 7348342 | Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine We describe substituted benzenesulfoximine compounds having anti-inflammatory activity, processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of inflammatory diseases. ... | 03/25/2008 |
| 7348343 | Amides useful for treating pain The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7 and R8 are defined herein. The present invention... | 03/25/2008 |
| RE40155 | Methods for treatment of benign and malignant tumors, including lymphomas, leukemias, and leiomyomas In a preferred embodiment, drugs having chemotherapeutic properties which are useful against certain neoplastic disorders with wide safety margins as evidenced by their low toxicity, and molecular actions. Such drugs include as active ingredient(s) one or more N-sub... | 03/18/2008 |
| 7304082 | 1,2,4-triazole derivatives, compositions, process of making and methods of use Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinopathy, rheumatoid arthritis, atherosclerotic neovasculari... | 12/04/2007 |
| 7273872 | Inhibition of inflammation using α 7 receptor-binding cholinergic agonists Methods for inhibiting an inflammatory cytokine cascade in a patient are provided. The methods are directed to treating the patient with a cholinergic agonist in an amount sufficient to inhibit the inflammatory cytokine cascade, wherein the cholinergic agonist is se... | 09/25/2007 |
| 7244745 | Heterocyclic compounds, methods for the preparation thereof, and uses thereof The compounds of the present invention are of formula I: wherein A, R3, R4 is as defined herein, are useful as ligands for nicotinic receptors. ... | 07/17/2007 |
| 7238715 | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor in an amount sufficient to decrease the amount of the proinflammatory... | 07/03/2007 |
| 7230017 | Dihydropyridinone derivatives The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failur... | 06/12/2007 |
| 7226935 | Hypoglycemic agent A zinc(II) complex which is lowly toxic, has high insulin-like activity, and is effectively usable as a hypoglycemic agent for the prevention or treatment of diabetes; a hypoglycemic agent containing the complex; a medicinal preparation which contains the complex an... | 06/05/2007 |
| 7208142 | Indanylidene compounds Novel indanylidene compounds can be used as UV-A filters in cosmetic compositions for protecting skin and hair and for technical applications. ... | 04/24/2007 |
| 7176198 | 1-pyrazole and 1-pyrrole-azabicyclic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is where the variables have the definitions discussed herein. These compounds may be in the... | 02/13/2007 |
| 7173046 | CD40:CD154 binding interrupter compounds and use thereof to treat immunological complications The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with inappropriate CD154 activation in a subject. Specifically, this invention ... | 02/06/2007 |
| 7160551 | Injectable system for controlled drug delivery An injectable composition for delivery of a bioactive agent contains a biocompatible solvent, a hydrophobic polymer, and an amphiphilic block copolymer. The hydrophobic polymer may be a biodegradable polymer, and the block copolymer may contain a segment of poly(eth... | 01/09/2007 |
| 7115611 | Phenyl derivatives, their manufacture and use as pharmaceutical agents This invention relates to compounds of the formula wherein one of R5, R6 and R7 is | 10/03/2006 |
| 7087106 | Materials and methods for inhibiting fouling of surfaces exposed to aquatic environments The subject invention provides materials and methods for inhibiting the biofouling of surfaces exposed to aquatic environments. In one embodiment, the subject invention provides additives for marine paints and surface treatments. The subject invention further provid... | 08/08/2006 |
| 7074809 | Compounds The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, X5, R, R1, R2, R3, R4,... | 07/11/2006 |
| 7067261 | Methods and compositions for treatment of central nervous system disorders The invention provides methods of screening for substances having an effect on a nicotine receptor by contacting a cell having a nicotine receptor with a test substance; and determining any increase or decrease in phosphorylation of Janus-Activated Kinase 2 (JAK2). ... | 06/27/2006 |
| 7067515 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease The invention provides compounds of Formula I: where in W is These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or... | 06/27/2006 |
| 7060715 | Substituted pyridines as selective cyclooxygenase-2 inhibitors The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. | 06/13/2006 |
| 7053219 | Isoxazolopyridone derivatives and their use The invention relates to isoxazolopyridone derivatives of a formula (I-a): wherein R1a represents an optionally-substituted heteroaryl or phenyl group, R2a represents an optionally-substitut... | 05/30/2006 |
| 7030141 | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat... | 04/18/2006 |
| 7001900 | Azabicyclic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is W is a six-membered heterocyclic ring system having 1–2 nitrogen atoms or a 10-membered bicyclic-six-... | 02/21/2006 |
| 6984649 | Pyridine derivatives Pyridine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 ... | 01/10/2006 |
| 6958359 | Vanadium compounds as anti-angiogenic agents Vanadium compounds for inhibiting angiogenesis useful for treating or preventing diabetic retinopathy, hemangiomas, cancers with abnormal blood vessel supply, restenosis following vascular injury, and the like. ... | 10/25/2005 |
| 6951868 | Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is any of: These compounds may be in the form of pharmaceutical salts or compositions, and racemic mixtu... | 10/04/2005 |
| 6951860 | Calcium channel blockers The invention involves the identification of a family of compounds which block calcium channels. The compounds can be formulated in pharmaceutical carriers and administered to subjects. The compounds are useful for treating disorders associated with calcium channel ... | 10/04/2005 |
| 6949571 | 1,2-dihydropyridine compounds, process for preparation of the same and use thereof The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. I... | 09/27/2005 |
| 6921768 | Cytostatic cerium compounds The invention relates to cerium compounds having general formulas (I) Rni+Yin− and (II) Rb+Yb+ and their application as medicaments in the prophylaxis and/or treatment of cance... | 07/26/2005 |
| 6919359 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: Azabicyclo-N(R1)—C(═X)—W Formula I These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Fo... | 07/19/2005 |
| 6911543 | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is These compounds may be in the form of pharmaceutical salts or co... | 06/28/2005 |
