Class 514/330 - C=X bonded directly to the piperidine ring (X is chalcogen)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein a C=O, C=S, C=Se
No. of patents: 628
Last issue date: 04/02/2013

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Number	Title	Issue Date
8410140	Anesthetic methods and compositions The present invention relates to compositions and methods use in pain reduction, including but not limited to, peripheral nerve blocks. In particular, the present invention relates to compositions and methods for the administration of perineural dexmedetomidine and ...	04/02/2013
8309579	N-hydroxyamide derivatives and use thereof The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory ...	11/13/2012
8288417	N-substituted piperidines and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases...	10/16/2012
8278330	Short duration depot formulations Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release o...	10/02/2012
8193220	Method of changing muscle lengths with anesthetic drugs According to one aspect, the fibers of a muscle to be shortened or lengthened are exposed to a local anesthetic drug such as bupivacaine. The concentration and volume of the local anesthetic drug are sufficient to causes the muscle fibers to be damaged by the myotox...	06/05/2012
8178559	Organic compounds 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the p...	05/15/2012
8153661	Controlled delivery system The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 h...	04/10/2012
8097637	Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their man...	01/17/2012
8071625	Certain chemical entities, compositions, and methods Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described. ...	12/06/2011
8071624	N-substituted piperidines and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases...	12/06/2011
8039490	Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r ...	10/18/2011
8026258	Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics.	09/27/2011
7932269	Sulfonamides as orexin antagonists The present invention is concerned with novel sulfonamides of formula wherein R1, R2, R3 and n are as described in the description and claims. The compounds are orexin receptor antagonists, ...	04/26/2011
7872028	Diaminopropanol renin inhibitors Described are diaminopropanols of which are orally active and bind to renin to inhibit its activity. They are useful in the treatment or amelioration of diseases associated with elevated. levels of renin activity or in the treatment of aspartic protease mediated dis...	01/18/2011
7754737	Diaminoalkane aspartic protease inhibitors Diaminoalkanes of Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The inventio...	07/13/2010
7700629	Use of a non-racemic mixture of bupivacaine enantiomers, for improving the anesthesia profile The present invention describes a new method for the separation of bupivacaine enantiomers consisting in a continuous separation process performed without heating, by the selective precipitation of their diastereomeric salts with tartaric acid. This heatless process...	04/20/2010
7674805	Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics.	03/09/2010
7625929	Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics The invention relates to the compounds of general formula (I) where R1 represents H, a (C1-C4)alkyl, —CO(C1-C4)alkyl, (C1-C4)alkylphenyl or —CO-phenyl group, said phenyl being optionally substituted, R2 ...	12/01/2009
7622489	Mitotic kinesin inhibitors The present invention relates to tetrahydropyridine compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which ...	11/24/2009
7572814	3,5-dibenzoyl-4-phenyl-piperidine anti-cancer compounds Certain 3,5-dibenzoyl-4-phenyl-piperidine compounds and salts thereof are provided herein. The compounds and salts may be useful in causing mitotic arrest and cell death. Also provided herein are certain pharmaceutical compositions comprising 3,5-dibenzoyl-4-phenyl-...	08/11/2009
7439257	Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics.	10/21/2008
7425641	Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1, the tautomers, stereoisomer...	09/16/2008
7378440	Substituted benzoylureido-o-benzoylamides, process for their preparation and their use The invention relates to substituted benzoylureido-o-benzoylamides and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of the formula I in which...	05/27/2008
7375117	Polypeptides The present invention relates to polypeptides, and nucleic acids DNA encoding these polypeptides, capable of eliciting an immune reaction against cancer, methods for generating T lymphocytes capable of recognizing and destroying tumor cells, and pharmaceutical compo...	05/20/2008
7368443	2,6-disubstituted piperidines and piperazine compounds The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: which are used to treat diseases of the central nervous system, drug abuse, and withdrawal there...	05/06/2008
7361666	Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-protein-couple...	04/22/2008
7358251	N-sulfonylurea apoptosis promoters Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. ...	04/15/2008
7354906	Composition of anti-HIV drugs and anti-cortisol compounds and method for decreasing the side effects of anti-HIV drugs in a human The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated with anti-HIV drugs. The invention also relates to a method of treati...	04/08/2008
7351702	Caspase inhibitors and uses thereof This invention provides compounds of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; next to R3 represents a...	04/01/2008
7351742	Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ...	04/01/2008
7351719	Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover t...	04/01/2008
7348437	Proteomic analysis Activity-based compositions for analyzing metalloproteases are disclosed, where the compositions include a chemical compound including a hydroxamate moiety and a benzophenone moiety. Methods for synthesizing these compounds are also disclosed, as well as methods of ...	03/25/2008
7348354	Cyclohexylurea compounds Cyclohexylurea compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and the use of such compounds as pharmaceutically active agents with nociceptin/ORL1 receptor sys...	03/25/2008
7338962	Spirocyclic heterocyclic derivatives and methods of their use Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be us...	03/04/2008
7323563	Hydroxamic acid derivatives as antibacterials A method for the treatment of bacterial infections in humans and non-human mammals, which comprises inhibiting bacterial growth by administering to a subject an antibacterially effective dose of a compound of formula (I) or a pharmaceutically or veterinarily accepta...	01/29/2008
7309714	Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved...	12/18/2007
7304171	Compounds and methods for cytoprotection Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I): including stereoisomers, prodrugs and pharmaceutically accepta...	12/04/2007
7294637	Method of treating addiction or dependence using a ligand for a monamine receptor or transporter One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a therapuetically effective amount of a heterocyclic compound, e.g., a 3-substitute...	11/13/2007
7291599	Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis and to an inflammatory reaction magnifying the damage, by the isolated ...	11/06/2007
7291620	N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also direct...	11/06/2007

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Class 514/330 - C=X bonded directly to the piperidine ring (X is chalcogen)