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| Number | Title | Issue Date |
| 8163774 | Amide-substituted 8-N-benzimidazoles, method for the production thereof, and use of the same as medicaments The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-loweri... | 04/24/2012 |
| 8148401 | Benzimidazole derivatives The present invention relates to a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3A, R3B, R4, R5, X, m, and n are... | 04/03/2012 |
| 8143282 | Heterocyclic compounds The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of pr... | 03/27/2012 |
| 8138207 | Aminocarbonyl-substituted 8-N-benzimidazoles, methods for their preparation and their use in pharmaceutical compositions The present invention comprises the use of amino-carbonyl-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sug... | 03/20/2012 |
| 8119661 | Piperidine derivatives and their use as muscarinic receptor modulators Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R2, R3, X, m and n are as defined in the specification as well as salts and pharmaceutical compositions including the compo... | 02/21/2012 |
| 8071623 | Amide substituted indazoles as poly(ADP-ribose)polymerase(PARP) inhibitors The present invention relates to compounds of formula I: and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatmen... | 12/06/2011 |
| 8071622 | Indoles The present invention is concerned with novel indol-2-yl-carbonyl-piperidin-benzoimidazolon and indol-2-yl-carbonyl-piperidin-benzoxazolon derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the t... | 12/06/2011 |
| 8026256 | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity. ... | 09/27/2011 |
| 8026257 | Substituted heterocyclic ethers and their use in CNS disorders The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders. ... | 09/27/2011 |
| 8012995 | Pharmaceutically active sulfonamide derivatives The present invention is related to sulfonamide derivatives of formula (I0 notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are efficient modulators ... | 09/06/2011 |
| 8008327 | Indazole compounds as CCR1 receptor antagonists Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis... | 08/30/2011 |
| 8003668 | Amino-substituted 8-N-benzimidazoles and methods for their use in blood sugar disorders The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-loweri... | 08/23/2011 |
| 8003669 | Remedy for sleep disturbance The present invention has been made based on the finding that a compound acting on the ORL-1 receptor as an agonist acts as a non-photic entrainment factor, and advances the circadian rhythm phase, and provides a novel therapeutic agent for a sleep disorder such as ... | 08/23/2011 |
| 7994197 | Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed compri... | 08/09/2011 |
| 7994196 | Indazole compound and pharmaceutical use thereof The present invention can provide a cancer treatment drug containing, as an active ingredient, a substance selected from the group consisting of an indazole compound of the following formula (I), a pharmaceutically acceptable salt, a hydrate, a water adduct and a so... | 08/09/2011 |
| 7968568 | Substituted piperidine derivatives as SST5 modulators This invention is concerned with compounds of the formula wherein A, R1 to R5 and G are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The invention further re... | 06/28/2011 |
| 7956069 | Compounds Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein A1, A2, G1, G2 G3, R1, R2, X, Y, Z, m, n and p are as defined in th... | 06/07/2011 |
| 7919510 | Substituted benzimidazole compounds with dual NOS inhibitory activity and mu opioid agonist activity The present invention relates to benzimidazole compounds having dual nitric oxide synthase (NOS) inhibitory activity and agonist activity at the mu-opioid receptor, to pharmaceutical and diagnostic compositions containing them, and to their medical use, particularly... | 04/05/2011 |
| 7906532 | Indazole derivatives This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: R1, R2, R3, A and m are each as described herein and compositions containing su... | 03/15/2011 |
| 7803815 | Indol-3-yl-corbonyl-piperidin-benzoimidazol derivatives The present invention relates to Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the residues R1 to R7 are ... | 09/28/2010 |
| 7803816 | MCH receptor antagonists Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 09/28/2010 |
| 7790751 | Azinyl-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 09/07/2010 |
| 7776885 | Benzimidazolone compounds having 5-HT4 receptor agonistic activity This invention provides a compound of the formula (I): or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds for the manufacture of medicament for gastroesop... | 08/17/2010 |
| 7737163 | Benzimidazolone carboxylic acid derivatives This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions co... | 06/15/2010 |
| 7723360 | Alkyl-and piperidine-substituted benzimidazole derivatives A compound of general formula 1a wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to provide pharma... | 05/25/2010 |
| 7705020 | Benzimidazolone carboxylic acid derivatives This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions co... | 04/27/2010 |
| 7662836 | Indazole having analgesic activity An indazole having analgesic activity, a method for the preparation thereof and a pharmaceutical composition containing the same; the indazole has the following general formula: where X, Ra, Rb, R... | 02/16/2010 |
| 7632849 | Indazolamides with analgesic activity An indazolamide (I), wherein X, R1, R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the description, and addition salts thereof with a pharmaceutically acceptable acid, a method for the preparation thereof and a pharmaceutical composition containing the sam... | 12/15/2009 |
| 7612095 | Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1-piperidinyl]ethyl]-αα-dimethyl-benzeneacetic acid Crystalline form 1 of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1 -piperidinyl]ethyl]-αα-dimethyl-benzen⊖eacetic acid Crystalline form 1 of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1 -piperidinyl]ethyl]-αα-dimethyl-benzen⊖eacetic acid of for... | 11/03/2009 |
| 7595329 | Benzimidazolone carboxylic acid derivatives This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions co... | 09/29/2009 |
| 7595330 | Benzimidazole thiophene compounds The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 09/29/2009 |
| 7589108 | 1-Heterocyclylalkyl-3-sulfonylindole or -indazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 09/15/2009 |
| 7566728 | Remedy for sleep disturbance The present invention has been made based on the finding that a compound acting on the ORL-1 receptor as an agonist acts as a non-photic entrainment factor, and advances the circadian rhythm phase, and provides a novel therapeutic agent for a sleep disorder such as ... | 07/28/2009 |
| 7563809 | Nociceptin analogs The invention relates to benzothiadiazole compounds of formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, A, B, C, W, Z and n are defined as set forth in t... | 07/21/2009 |
| 7560470 | Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. ... | 07/14/2009 |
| 7544701 | Sulfonyldihydrobenzimidazolone compounds as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor. ... | 06/09/2009 |
| 7544700 | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein JunKinases The present invention is related to sulfonamide derivatives having a lipophilic moiety and which are substantially soluble. Said compounds are notably for use as pharmaceutically active compounds. The present invention also related to pharmaceutical formulations con... | 06/09/2009 |
| 7541370 | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor. ... | 06/02/2009 |
| 7528155 | Indazole derivatives as inhibitors of hormone sensitive lipase The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs. ... | 05/05/2009 |
| 7456198 | Benzimidazole compounds having nociceptin receptor affinity Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in... | 11/25/2008 |
