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| Number | Title | Issue Date |
| 8076302 | Pyrimidine nucleoside derivatives and salts thereof A novel pyrimidine nucleoside derivative represented by the following formula (1) and a salt thereof, as well as a pharmaceutical composition comprising the same as an active ingredient have excellent antiviral properties and are useful as antiviral therapeutic agen... | 12/13/2011 |
| 8058247 | Antibacterial agent and therapeutic agent for johne's disease containing the same An antibacterial agent having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity against Mycobacterium avium... | 11/15/2011 |
| 7323452 | Method for the accelerated in vivo removal of ethanol A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives... | 01/29/2008 |
| 7157078 | Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to ... | 01/02/2007 |
| 7153877 | Method and composition for preventing or reducing the symptoms of insulin resistance syndrome A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bo... | 12/26/2006 |
| 7119110 | Method and composition for preventing or reducing the symptoms of insulin resistance syndrome A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bo... | 10/10/2006 |
| 7067494 | Antimitotic eleuthesides This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore witho... | 06/27/2006 |
| 7033381 | Photodynamic stimulation device and method A treatment device which uses cold red and infrared radiation for the photodynamic stimulation of cells, especially cells of human tissue. The described device produces a constant energy radiation by the use of semiconductor and/or laser diodes, which furthermore ra... | 04/25/2006 |
| 6939859 | Skin preparations for external use An dermatological agent for external use is disclosed which contains a chromanol glycoside represented by the following general formula (1) (wherein R1, R2, R3, and R4 which ... | 09/06/2005 |
| 6916849 | Compositions for improving lipid content in the blood The present invention relates to compositions for lowering the total amount of cholesterol in the blood and methods of using the compositions. The compositions are a mixture of pravastatin and one or more vitamins selected from riboflavins, d-α-tocopherols, ascorbi... | 07/12/2005 |
| 6913772 | Composition useful as hepatoprotectants comprising extract of plant Cryptolepis buchanani and a method thereof The present invention relates to a composition useful for hepatoprotection, said composition comprising polar extract of plant Cryptolepis Buchanani and/or fractions of the said extract, and optionally pharmaceutically acceptable additives and a method of pro... | 07/05/2005 |
| 6887854 | Compounds as dynamic organ function monitoring agents Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for opti... | 05/03/2005 |
| 6852484 | Methods for the identification of inhibitors of asparagine synthase as antibiotics The present inventors have discovered that Asparagine Synthase is essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase gene expression in fungi results in no signs of successful infection or lesions. Thus, Asparagine Synthase can b... | 02/08/2005 |
| 6849607 | Galectin recognized photosensitizers for photodynamic therapy Purpurin-carbohydrate conjugates and their method of preparation and use for treatment of cancer cells. The conjugates have the general formula: wherein R6 and R7 taken together are ═NR11 | 02/01/2005 |
| 6833445 | Guanidinylation, guanidinoglycosides, uses, and methods of assaying their activity Provided are reagents and methods useful for the synthesis of guanidinylated compounds. Also provided are methods for assaying molecules, including guanidinylated molecules that modulate viral infection and replication. ... | 12/21/2004 |
| 6833362 | Method and composition for the accelerated in vivo removal of ethanol A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinami... | 12/21/2004 |
| 6716421 | Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of te... | 04/06/2004 |
| 6608103 | Inhibitor for neovasculation, cell multiplication, lumen formation and FGF This invention relates to an inhibitor having inhibitory activity against neovasculation, cell multiplication, lumen formation and fibroblast growth factor which comprises ଲ-, γ- or δ-tocotrienol.... | 08/19/2003 |
| 6538027 | Compositions comprising ratite oil or active fractions thereof and methods of using these composition as insect repellents This invention provides compositions for repelling insects, particularly biting insects, such as mosquitoes, ticks, and biting flies comprising ratite oil, active fractions of ratite oil obtained by flash chromatography or compositions comprising mixtures... | 03/25/2003 |
| 6518250 | Agent for preventing and curing hindrance of ischemic reperfusion An agent for preventing and curing the hindrance of ischemic reperfusiton is disclosed which has as an active component thereof a chromanol glycoside represented by the following general formula: ##STR1## [wherein R1, R2, R3 | 02/11/2003 |
| 6506734 | 20(S) camptothecin glycoconjugates The present invention relates to glycoconjugates of 20(S)-camptothecin, in which a 3-O-methylated ଲ-L-fucose unit is linked to the 20-hydroxyl group of a camptothecin derivative via a thiourea-modified peptide spacer. The invention furthermore relat... | 01/14/2003 |
| 6492335 | Glycoconjugates from modified camptothecin derivatives (20-O-linkage) The present invention relates to glycoconjugates of camptothecin derivatives in which at least one carbohydrate component is linked via suitable spacers with the 20-hydroxyl group of a camptothecin derivative. The invention furthermore relates to processe... | 12/10/2002 |
| 6486129 | Antithrombotic compounds ##STR1## The present invention relates to compounds of formula (1), wherein R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso)quinolinyl, tetrahydro(iso)quinolinyl, 3,4-dihydro-1H-isoquinolinyl, chromanyl or the camphor group, which grou... | 11/26/2002 |
| 6290929 | Cancer treatment This invention is a method of treating cancer, including carcinomas and sarcomas, through the administration of a pharmaceutical composition containing an arylaldehyde 5-oxo-1,2,4-triazine hydrazide derivative. The arylaldehyde 5-oxo-1,2,4-triazine hydraz... | 09/18/2001 |
| 6239114 | Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols Compositions and methods for the prevention and treatment of neoplastic diseases are described. Individuals at a high risk of developing or having neoplasia undergoing conventional therapies may be treated with an effective dose of triterpene derivatives ... | 05/29/2001 |
| 6221357 | Flavonoids derived from citrus peels as collagen-induced platelet aggregation inhibitor A method for inhibiting a collagen-induced platelet aggregation in a mammal comprises administering an effective amount of a flavonoid derived from citrus peels thereto.... | 04/24/2001 |
| 6107276 | Pharmaceutical compositions including a drug, a cross-linked polymeric substance, an oil, and a surface active agent The pharmaceutical compositions including a slightly soluble drug incorporated in a water-swellable, but water-insoluble cross-linked polymer, a surface active agent, and an oil show much improved dissolution and, consequently, bioavailability in respect ... | 08/22/2000 |
| 6022866 | Use of hyaluronic acid and forms to prevent arterial restenosis A method is provided of inhibiting the narrowing of the vascular tubular walls of an animal by the proliferation of endothelial cells in the area of trauma after the vascular tubular walls have been traumatized, the method comprising the administration of... | 02/08/2000 |
| 5977077 | Xanthone analogs for the treatment of infectious diseases Therapeutic compositions for the treatment of infectious diseases are disclosed. These compositions comprise xanthones and xanthone derivatives, such as 2,3,4,5,6-pentahydroxyxanthone. Also disclosed are methods for the treatment of infectious diseases us... | 11/02/1999 |
| 5972993 | Composition and method for treating rosacea and sensitive skin with free radical scavengers A method for treating skin conditions, such as rosacea and sensitive skin, that manifest as a tendency towards flushing and blushing is provided. Also provided herein, are compositions for the treatment of rosacea and sensitive skin that are comprised of ... | 10/26/1999 |
| 5965571 | Cholinesterase inhibitors for treatment of Parkinson's disease Parkinson's disease can be treated with an at least one cholinesterase inhibitor. The cholinesterase inhibitor has been found to alleviate both any symptoms of dementia as well as to reduce rigidity and improve motor function.... | 10/12/1999 |
| 5945406 | Therapeutic compounds with pyrimidine base Compounds of formula (I): ##STR1## wherein: R is halogen; Y is hydrogen, NH2, SH or OH; X is: ##STR2## wherein: either R1 or R2 is a bond, with the other being hydrogen; either R3 or R4 is h... | 08/31/1999 |
| 5929113 | Compositions comprising EMU oil or active fractions thereof and methods of using these compositions as insect repellents This invention provides a method for repelling biting insects such as mosquitoes, ticks, and biting flies by topically applying to the skin of a subject emu oil, fractions of emu oil obtained by flash chromatography or a composition comprising emu oil or ... | 07/27/1999 |
| 5925621 | Method for preventing sexually transmitted diseases A method for the reduction in the risk of transmitting a sexually transmitted disease--especially HIV and/or HSV--during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably... | 07/20/1999 |
| 5843937 | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy dihydrobenzindole oligopeptides and prodrugs thereof wherein the monomer... | 12/01/1998 |
| 5776925 | Methods for cancer chemosensitization Methods for cancer chemosensitization are provided. Texaphyrins are new chemosensitizers for enhancing the cytotoxicity of chemotherapeutic agents. The enhancement appears to be P-glycoprotein-independent since texaphyrins are effective in both a P-glycop... | 07/07/1998 |
| 5750563 | Preparation for epidermis A preparation for epidermis containing kojic acid and/or its derivative, which has improved preparation stability, is provided. The preparation stability is imparted by adding to the preparation at least one member selected from the group consisting of al... | 05/12/1998 |
| 5677285 | Derivatives of neuraminic acid Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including carboxylic amides, their 2-hydrocarbyl-glycosides, and their ... | 10/14/1997 |
| 5672618 | Protein kinase C inhibitors The present invention discloses compounds that are highly isozyme selective protein kinase C beta-1 and beta-2 isozyme inhibitors. Accordingly, the present invention provides a method of selectively inhibiting protein kinase C isozymes beta-1, and beta-2.... | 09/30/1997 |
| 5646124 | Method of treating cancer by conjunctive therapy with N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent The present invention relates to a method of treating a patient suffering from a neoplastic disease state comprising administering to said patient an effective antineoplastic amount of N,N'-bis[3-(ethylamino)propyl]-1,7-heptanediamine in conjunctive thera... | 07/08/1997 |
